ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 118/637 423/7206 1.80552701791e-32 ko04724 Glutamatergic synapse 61/637 152/7206 3.56861066746e-26 ko05033 Nicotine addiction 34/637 56/7206 2.18755057582e-22 ko04727 GABAergic synapse 44/637 110/7206 4.50625312976e-19 ko04713 Circadian entrainment 49/637 136/7206 7.83080060105e-19 ko05032 Morphine addiction 43/637 110/7206 3.25972036324e-18 ko04728 Dopaminergic synapse 57/637 185/7206 4.9107599867e-18 ko04723 Retrograde endocannabinoid signaling 55/637 175/7206 7.13062710523e-18 ko04024 cAMP signaling pathway 66/637 279/7206 2.69195558122e-14 ko04921 Oxytocin signaling pathway 54/637 209/7206 1.5387102729e-13 ko04725 Cholinergic synapse 45/637 160/7206 7.14854258347e-13 ko04261 Adrenergic signaling in cardiomyocytes 52/637 205/7206 9.76953245428e-13 ko04911 Insulin secretion 37/637 117/7206 1.73648327183e-12 ko04721 Synaptic vesicle cycle 29/637 80/7206 1.03349665649e-11 ko05031 Amphetamine addiction 31/637 91/7206 1.30177002177e-11 ko04726 Serotonergic synapse 38/637 137/7206 7.34164254496e-11 ko04720 Long-term potentiation 31/637 99/7206 1.52093758575e-10 ko04020 Calcium signaling pathway 55/637 265/7206 1.32266498525e-09 ko04742 Taste transduction 21/637 61/7206 2.22715990545e-08 ko05030 Cocaine addiction 23/637 73/7206 3.23415710548e-08 ko04970 Salivary secretion 26/637 95/7206 1.03880043254e-07 ko04010 MAPK signaling pathway 56/637 321/7206 5.17174839904e-07 ko04060 Cytokine-cytokine receptor interaction 1/637 191/7206 7.76042855095e-07 ko04740 Olfactory transduction 22/637 80/7206 9.14726652199e-07 ko05203 Viral carcinogenesis 5/637 277/7206 1.31846291412e-06 ko04730 Long-term depression 21/637 78/7206 2.35880528147e-06 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 21/637 79/7206 2.95142861838e-06 ko04971 Gastric acid secretion 23/637 98/7206 9.9582054586e-06 ko04925 Aldosterone synthesis and secretion 24/637 105/7206 1.03916516692e-05 ko04022 cGMP-PKG signaling pathway 38/637 216/7206 4.17300032476e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 18/637 74/7206 5.50843834663e-05 ko04745 Phototransduction - fly 12/637 38/7206 6.45856882737e-05 ko04915 Estrogen signaling pathway 26/637 131/7206 6.75124274716e-05 ko04260 Cardiac muscle contraction 21/637 98/7206 0.000100695008658 ko04070 Phosphatidylinositol signaling system 23/637 112/7206 0.000124462974807 ko05414 Dilated cardiomyopathy 23/637 112/7206 0.000124462974807 ko04744 Phototransduction 11/637 36/7206 0.000181514273692 ko04371 Apelin signaling pathway 31/637 177/7206 0.000219695192425 ko05410 Hypertrophic cardiomyopathy (HCM) 21/637 100/7206 0.000226006498886 ko04072 Phospholipase D signaling pathway 33/637 197/7206 0.000296367521097 ko04924 Renin secretion 18/637 86/7206 0.000421969024643 ko05168 Herpes simplex infection 4/637 182/7206 0.00046951579824 ko04626 Plant-pathogen interaction 7/637 18/7206 0.000545357019826 ko04972 Pancreatic secretion 21/637 111/7206 0.000993959968216 ko04350 TGF-beta signaling pathway 1/637 103/7206 0.0013328179542 ko00562 Inositol phosphate metabolism 17/637 89/7206 0.00202241243526 ko04014 Ras signaling pathway 40/637 279/7206 0.00237465738562 ko00512 Mucin type O-glycan biosynthesis 8/637 29/7206 0.00286553714665 ko04750 Inflammatory mediator regulation of TRP channels 21/637 122/7206 0.0031080442947 ko04670 Leukocyte transendothelial migration 4/637 151/7206 0.0034583741665 ko05322 Systemic lupus erythematosus 4/637 151/7206 0.0034583741665 ko05034 Alcoholism 34/637 238/7206 0.00494347308756 ko05164 Influenza A 5/637 167/7206 0.00518717229161 ko04912 GnRH signaling pathway 20/637 122/7206 0.00579135493195 ko04114 Oocyte meiosis 22/637 139/7206 0.00616997333286 ko04540 Gap junction 21/637 128/7206 0.00659966586856 ko04514 Cell adhesion molecules (CAMs) 21/637 130/7206 0.00703351787614 ko05169 Epstein-Barr virus infection 8/637 206/7206 0.00842439821015 ko04722 Neurotrophin signaling pathway 24/637 160/7206 0.0103055952511 ko04922 Glucagon signaling pathway 20/637 128/7206 0.0110009236183 ko04150 mTOR signaling pathway 7/637 184/7206 0.0118112065521 ko04550 Signaling pathways regulating pluripotency of stem cells 6/637 165/7206 0.0123002554813 ko04630 Jak-STAT signaling pathway 4/637 132/7206 0.0126845744385 ko04360 Axon guidance 32/637 233/7206 0.0130205060898 ko04612 Antigen processing and presentation 1/637 77/7206 0.0134918638586 ko00240 Pyrimidine metabolism 3/637 110/7206 0.0170755463974 ko04110 Cell cycle 5/637 145/7206 0.0171977854913 ko04214 Apoptosis - fly 1/637 72/7206 0.0195236653819 ko04621 NOD-like receptor signaling pathway 6/637 157/7206 0.0220977423042 ko04146 Peroxisome 2/637 89/7206 0.0225802622044 ko00650 Butanoate metabolism 6/637 26/7206 0.0231652615561 ko05202 Transcriptional misregulation in cancer 8/637 188/7206 0.0256859628728 ko04973 Carbohydrate digestion and absorption 8/637 42/7206 0.0284941106921 ko05205 Proteoglycans in cancer 14/637 271/7206 0.02863493276 ko04142 Lysosome 6/637 151/7206 0.0293014908008 ko03320 PPAR signaling pathway 1/637 69/7206 0.0293922929365 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/637 14/7206 0.0295484369489 ko04120 Ubiquitin mediated proteolysis 5/637 138/7206 0.0321139574204 ko05162 Measles 4/637 120/7206 0.0330369713163 ko03013 RNA transport 7/637 166/7206 0.0364585458582 ko04961 Endocrine and other factor-regulated calcium reabsorption 10/637 59/7206 0.0366297584843 ko00600 Sphingolipid metabolism 1/637 63/7206 0.0413826649193 ko05010 Alzheimer's disease 26/637 202/7206 0.0444909141339 ko05166 HTLV-I infection 16/637 292/7206 0.0445739220498 ko03008 Ribosome biogenesis in eukaryotes 2/637 79/7206 0.0447928164039 ko04064 NF-kappa B signaling pathway 3/637 96/7206 0.045309252217