ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 114/598 423/7206 1.75217354397e-32 ko04724 Glutamatergic synapse 47/598 152/7206 3.40174078207e-16 ko04713 Circadian entrainment 41/598 136/7206 7.4951167974e-14 ko04020 Calcium signaling pathway 60/598 265/7206 2.06056340807e-13 ko05033 Nicotine addiction 25/598 56/7206 2.77832857841e-13 ko04024 cAMP signaling pathway 60/598 279/7206 2.22564921471e-12 ko04921 Oxytocin signaling pathway 47/598 209/7206 1.24845346354e-10 ko04720 Long-term potentiation 30/598 99/7206 1.57426945941e-10 ko04727 GABAergic synapse 31/598 110/7206 5.89961647488e-10 ko05032 Morphine addiction 31/598 110/7206 5.89961647488e-10 ko04911 Insulin secretion 32/598 117/7206 7.18122410599e-10 ko05031 Amphetamine addiction 27/598 91/7206 2.22451883343e-09 ko04728 Dopaminergic synapse 41/598 185/7206 3.17049268205e-09 ko04726 Serotonergic synapse 34/598 137/7206 3.41878680514e-09 ko04971 Gastric acid secretion 26/598 98/7206 5.75647568857e-08 ko04725 Cholinergic synapse 35/598 160/7206 6.5885723124e-08 ko04745 Phototransduction - fly 15/598 38/7206 1.30739085235e-07 ko04723 Retrograde endocannabinoid signaling 36/598 175/7206 2.20565965132e-07 ko04925 Aldosterone synthesis and secretion 26/598 105/7206 2.58647038833e-07 ko04070 Phosphatidylinositol signaling system 26/598 112/7206 9.98144962189e-07 ko04742 Taste transduction 18/598 61/7206 1.19178525937e-06 ko04970 Salivary secretion 23/598 95/7206 1.94367495768e-06 ko04261 Adrenergic signaling in cardiomyocytes 37/598 205/7206 4.56568889788e-06 ko04710 Circadian rhythm 14/598 43/7206 5.13432609657e-06 ko04750 Inflammatory mediator regulation of TRP channels 26/598 122/7206 5.4983981397e-06 ko04022 cGMP-PKG signaling pathway 38/598 216/7206 7.19052041355e-06 ko04730 Long-term depression 19/598 78/7206 1.37890587213e-05 ko04626 Plant-pathogen interaction 8/598 18/7206 4.43819993674e-05 ko04922 Glucagon signaling pathway 25/598 128/7206 5.4088827065e-05 ko04924 Renin secretion 19/598 86/7206 5.96679288841e-05 ko05322 Systemic lupus erythematosus 1/598 151/7206 6.50941913972e-05 ko05030 Cocaine addiction 17/598 73/7206 7.20080405019e-05 ko04060 Cytokine-cytokine receptor interaction 3/598 191/7206 9.24010951257e-05 ko03040 Spliceosome 1/598 145/7206 9.26304358744e-05 ko05168 Herpes simplex infection 3/598 182/7206 0.000190860734831 ko04072 Phospholipase D signaling pathway 32/598 197/7206 0.00019456611581 ko04740 Olfactory transduction 17/598 80/7206 0.000238806015055 ko03010 Ribosome 1/598 129/7206 0.000290697102457 ko05169 Epstein-Barr virus infection 5/598 206/7206 0.000736021268564 ko05203 Viral carcinogenesis 9/598 277/7206 0.000796491135907 ko05014 Amyotrophic lateral sclerosis (ALS) 15/598 74/7206 0.000924434736718 ko04540 Gap junction 22/598 128/7206 0.000934893877646 ko05166 HTLV-I infection 10/598 292/7206 0.00104862805668 ko04514 Cell adhesion molecules (CAMs) 22/598 130/7206 0.00109012088953 ko00680 Methane metabolism 9/598 34/7206 0.00139283501065 ko04114 Oocyte meiosis 23/598 139/7206 0.0014978754453 ko05200 Pathways in cancer 23/598 492/7206 0.00166195241411 ko05164 Influenza A 4/598 167/7206 0.0025520985074 ko04711 Circadian rhythm - fly 5/598 13/7206 0.0028364226538 ko05162 Measles 2/598 120/7206 0.00393471320976 ko00010 Glycolysis / Gluconeogenesis 14/598 74/7206 0.00428168391957 ko04960 Aldosterone-regulated sodium reabsorption 9/598 41/7206 0.00551642686656 ko04630 Jak-STAT signaling pathway 3/598 132/7206 0.00636124446342 ko04721 Synaptic vesicle cycle 14/598 80/7206 0.00655475586285 ko04014 Ras signaling pathway 36/598 279/7206 0.00747535323552 ko04964 Proximal tubule bicarbonate reclamation 7/598 29/7206 0.00812161328635 ko04260 Cardiac muscle contraction 16/598 98/7206 0.00834373559873 ko04110 Cell cycle 4/598 145/7206 0.0093651014614 ko04141 Protein processing in endoplasmic reticulum 6/598 184/7206 0.00940365328657 ko04550 Signaling pathways regulating pluripotency of stem cells 5/598 165/7206 0.00950835746252 ko00562 Inositol phosphate metabolism 15/598 89/7206 0.0099720940839 ko04350 TGF-beta signaling pathway 2/598 103/7206 0.0113252446455 ko03008 Ribosome biogenesis in eukaryotes 1/598 79/7206 0.0134436939613 ko04972 Pancreatic secretion 17/598 111/7206 0.0134723906922 ko01230 Biosynthesis of amino acids 14/598 85/7206 0.0149703285702 ko04978 Mineral absorption 8/598 40/7206 0.0153055294446 ko04510 Focal adhesion 10/598 240/7206 0.0166118560631 ko05161 Hepatitis B 6/598 173/7206 0.0168391485353 ko04668 TNF signaling pathway 3/598 120/7206 0.017808496016 ko04621 NOD-like receptor signaling pathway 5/598 157/7206 0.0179183719294 ko04912 GnRH signaling pathway 18/598 122/7206 0.0185598528243 ko05130 Pathogenic Escherichia coli infection 1/598 77/7206 0.0199408460876 ko04612 Antigen processing and presentation 1/598 77/7206 0.0199408460876 ko05214 Glioma 13/598 79/7206 0.0209124914034 ko03013 RNA transport 6/598 166/7206 0.0223212269995 ko04744 Phototransduction 7/598 36/7206 0.0262471592301 ko05010 Alzheimer's disease 26/598 202/7206 0.0265640589441 ko04214 Apoptosis - fly 1/598 72/7206 0.0289152319997 ko05222 Small cell lung cancer 2/598 89/7206 0.0322043732735 ko05145 Toxoplasmosis 4/598 126/7206 0.0329255139326 ko00240 Pyrimidine metabolism 3/598 110/7206 0.0341563403461 ko04144 Endocytosis 18/598 342/7206 0.0348331443585 ko04010 MAPK signaling pathway 37/598 321/7206 0.0379318865137 ko04270 Vascular smooth muscle contraction 20/598 154/7206 0.0385288703464 ko04360 Axon guidance 28/598 233/7206 0.0403059752141 ko04120 Ubiquitin mediated proteolysis 5/598 138/7206 0.0421041646572 ko00564 Glycerophospholipid metabolism 14/598 99/7206 0.0422564714339 ko00030 Pentose phosphate pathway 6/598 32/7206 0.0450525622474