ko pathway ratio_in_study ratio_in_pop p_value ko04070 Phosphatidylinositol signaling system 10/121 112/7206 1.64038070579e-05 ko04720 Long-term potentiation 9/121 99/7206 3.83137745841e-05 ko04270 Vascular smooth muscle contraction 9/121 154/7206 0.00108216786724 ko05231 Choline metabolism in cancer 8/121 134/7206 0.00179151088431 ko04745 Phototransduction - fly 4/121 38/7206 0.00359266060967 ko00561 Glycerolipid metabolism 5/121 63/7206 0.00397233225096 ko05031 Amphetamine addiction 6/121 91/7206 0.00412979719879 ko04912 GnRH signaling pathway 7/121 122/7206 0.00430841477658 ko04750 Inflammatory mediator regulation of TRP channels 7/121 122/7206 0.00430841477658 ko00100 Steroid biosynthesis 3/121 21/7206 0.00492523219666 ko04970 Salivary secretion 6/121 95/7206 0.00510095197396 ko04922 Glucagon signaling pathway 7/121 128/7206 0.0055995857181 ko03320 PPAR signaling pathway 5/121 69/7206 0.00586567956882 ko04713 Circadian entrainment 7/121 136/7206 0.00774821785214 ko04931 Insulin resistance 7/121 137/7206 0.00805444588619 ko04921 Oxytocin signaling pathway 9/121 209/7206 0.00835369001285 ko04730 Long-term depression 5/121 78/7206 0.0097821700009 ko04919 Thyroid hormone signaling pathway 7/121 143/7206 0.0100830695912 ko04972 Pancreatic secretion 6/121 111/7206 0.0107082107837 ko00920 Sulfur metabolism 2/121 10/7206 0.0115226694534 ko00950 Isoquinoline alkaloid biosynthesis 2/121 10/7206 0.0115226694534 ko04011 MAPK signaling pathway - yeast 4/121 53/7206 0.0117576222398 ko04728 Dopaminergic synapse 8/121 185/7206 0.0123844868824 ko04930 Type II diabetes mellitus 4/121 54/7206 0.012537074831 ko04020 Calcium signaling pathway 10/121 265/7206 0.0133652241161 ko04724 Glutamatergic synapse 7/121 152/7206 0.0137934297342 ko05143 African trypanosomiasis 3/121 32/7206 0.0160702057611 ko04666 Fc gamma R-mediated phagocytosis 6/121 122/7206 0.0164881785448 ko04146 Peroxisome 5/121 89/7206 0.0166388690116 ko00562 Inositol phosphate metabolism 5/121 89/7206 0.0166388690116 ko00350 Tyrosine metabolism 3/121 33/7206 0.017464801954 ko04725 Cholinergic synapse 7/121 160/7206 0.017838089198 ko00330 Arginine and proline metabolism 4/121 61/7206 0.0189221333689 ko04139 Mitophagy - yeast 3/121 37/7206 0.0237001858645 ko05223 Non-small cell lung cancer 4/121 66/7206 0.0245247912027 ko00564 Glycerophospholipid metabolism 5/121 99/7206 0.0251463292754 ko04910 Insulin signaling pathway 7/121 172/7206 0.0253770235561 ko04933 AGE-RAGE signaling pathway in diabetic complications 6/121 135/7206 0.0257440098067 ko04726 Serotonergic synapse 6/121 137/7206 0.0274228354584 ko04960 Aldosterone-regulated sodium reabsorption 3/121 41/7206 0.0309884101966 ko04925 Aldosterone synthesis and secretion 5/121 105/7206 0.0313878360776 ko00360 Phenylalanine metabolism 2/121 17/7206 0.0322628134324 ko00051 Fructose and mannose metabolism 3/121 42/7206 0.0329740928923 ko00909 Sesquiterpenoid and triterpenoid biosynthesis 1/121 2/7206 0.0333034600094 ko04370 VEGF signaling pathway 4/121 77/7206 0.0400705872172 ko00120 Primary bile acid biosynthesis 2/121 20/7206 0.0436309732339 ko05230 Central carbon metabolism in cancer 4/121 81/7206 0.0468446176989 ko04072 Phospholipase D signaling pathway 7/121 197/7206 0.0475310070473 ko04137 Mitophagy - animal 4/121 82/7206 0.0486318638423 ko00261 Monobactam biosynthesis 1/121 3/7206 0.0495403119434