ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	186/1106	423/7206	2.77411936761e-48
ko05033	Nicotine addiction	48/1106	56/7206	1.44054751466e-31
ko04724	Glutamatergic synapse	85/1106	152/7206	1.71168990091e-31
ko04727	GABAergic synapse	63/1106	110/7206	2.36794327567e-24
ko05032	Morphine addiction	63/1106	110/7206	2.36794327567e-24
ko04713	Circadian entrainment	71/1106	136/7206	5.09993293863e-24
ko04721	Synaptic vesicle cycle	51/1106	80/7206	6.39478609966e-23
ko04728	Dopaminergic synapse	81/1106	185/7206	6.86121540583e-21
ko04725	Cholinergic synapse	72/1106	160/7206	1.65604047522e-19
ko04723	Retrograde endocannabinoid signaling	75/1106	175/7206	9.34586585167e-19
ko04911	Insulin secretion	55/1106	117/7206	3.30572216646e-16
ko04742	Taste transduction	37/1106	61/7206	6.29146477644e-16
ko04024	cAMP signaling pathway	95/1106	279/7206	2.80594297982e-15
ko04726	Serotonergic synapse	57/1106	137/7206	7.47213281356e-14
ko04744	Phototransduction	25/1106	36/7206	3.83030838047e-13
ko04921	Oxytocin signaling pathway	73/1106	209/7206	1.35314343925e-12
ko04020	Calcium signaling pathway	86/1106	265/7206	1.63895763285e-12
ko04740	Olfactory transduction	39/1106	80/7206	1.71324827763e-12
ko04720	Long-term potentiation	42/1106	99/7206	7.1700465112e-11
ko05031	Amphetamine addiction	39/1106	91/7206	2.39016285667e-10
ko04261	Adrenergic signaling in cardiomyocytes	66/1106	205/7206	7.97832724278e-10
ko03040	Spliceosome	1/1106	145/7206	1.37438281675e-09
ko04970	Salivary secretion	38/1106	95/7206	4.34565220858e-09
ko05203	Viral carcinogenesis	13/1106	277/7206	2.05031698816e-08
ko05168	Herpes simplex infection	6/1106	182/7206	1.88891378513e-07
ko05030	Cocaine addiction	29/1106	73/7206	3.54775793173e-07
ko04925	Aldosterone synthesis and secretion	37/1106	105/7206	3.6061291801e-07
ko04971	Gastric acid secretion	35/1106	98/7206	5.57104422007e-07
ko03013	RNA transport	6/1106	166/7206	1.78355458848e-06
ko04010	MAPK signaling pathway	81/1106	321/7206	2.41875289587e-06
ko04360	Axon guidance	63/1106	233/7206	2.94105072793e-06
ko04120	Ubiquitin mediated proteolysis	4/1106	138/7206	3.48784395834e-06
ko04540	Gap junction	40/1106	128/7206	5.00313330848e-06
ko04060	Cytokine-cytokine receptor interaction	9/1106	191/7206	5.44065970154e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1106	79/7206	9.72786781042e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1106	74/7206	1.02895837873e-05
ko05322	Systemic lupus erythematosus	6/1106	151/7206	1.09398476475e-05
ko04022	cGMP-PKG signaling pathway	57/1106	216/7206	2.02787656341e-05
ko04730	Long-term depression	27/1106	78/7206	2.1014338899e-05
ko04621	NOD-like receptor signaling pathway	7/1106	157/7206	2.56438278041e-05
ko05164	Influenza A	8/1106	167/7206	2.79260096504e-05
ko05162	Measles	4/1106	120/7206	3.26081591535e-05
ko04966	Collecting duct acid secretion	13/1106	26/7206	3.59247742408e-05
ko04141	Protein processing in endoplasmic reticulum	10/1106	184/7206	4.259899933e-05
ko04610	Complement and coagulation cascades	1/1106	79/7206	5.21374880081e-05
ko04924	Renin secretion	28/1106	86/7206	5.7083826486e-05
ko04514	Cell adhesion molecules (CAMs)	38/1106	130/7206	6.15551225308e-05
ko04745	Phototransduction - fly	16/1106	38/7206	6.63461929866e-05
ko04972	Pancreatic secretion	33/1106	111/7206	9.51689643029e-05
ko04260	Cardiac muscle contraction	30/1106	98/7206	0.000108010770261
ko04976	Bile secretion	26/1106	80/7206	0.000115053612023
ko04964	Proximal tubule bicarbonate reclamation	13/1106	29/7206	0.000149380670932
ko05169	Epstein-Barr virus infection	14/1106	206/7206	0.000251247309021
ko04014	Ras signaling pathway	65/1106	279/7206	0.000350207957133
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1106	59/7206	0.000360352782329
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/1106	182/7206	0.000369365255915
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1106	14/7206	0.00037928463544
ko04110	Cell cycle	8/1106	145/7206	0.000405358420486
ko03008	Ribosome biogenesis in eukaryotes	2/1106	79/7206	0.000411887224245
ko05140	Leishmaniasis	2/1106	75/7206	0.000597390056698
ko04612	Antigen processing and presentation	2/1106	77/7206	0.000626929624488
ko04072	Phospholipase D signaling pathway	48/1106	197/7206	0.00085223838137
ko04064	NF-kappa B signaling pathway	4/1106	96/7206	0.000884175360409
ko05205	Proteoglycans in cancer	23/1106	271/7206	0.00102347595768
ko05414	Dilated cardiomyopathy	30/1106	112/7206	0.00206411770201
ko04070	Phosphatidylinositol signaling system	30/1106	112/7206	0.00206411770201
ko04750	Inflammatory mediator regulation of TRP channels	32/1106	122/7206	0.00207718961821
ko00520	Amino sugar and nucleotide sugar metabolism	1/1106	55/7206	0.00209373460931
ko00480	Glutathione metabolism	1/1106	55/7206	0.00209373460931
ko05110	Vibrio cholerae infection	19/1106	63/7206	0.00246214521239
ko04657	IL-17 signaling pathway	4/1106	87/7206	0.00254134682562
ko04146	Peroxisome	4/1106	89/7206	0.00263354909945
ko04640	Hematopoietic cell lineage	2/1106	64/7206	0.00279433323921
ko04915	Estrogen signaling pathway	33/1106	131/7206	0.00305711860532
ko00590	Arachidonic acid metabolism	1/1106	52/7206	0.00311372383795
ko03018	RNA degradation	4/1106	84/7206	0.00360151461714
ko05166	HTLV-I infection	28/1106	292/7206	0.00466662065242
ko04214	Apoptosis - fly	3/1106	72/7206	0.0047260689104
ko04350	TGF-beta signaling pathway	6/1106	103/7206	0.00532923277803
ko05161	Hepatitis B	14/1106	173/7206	0.00535673548717
ko00330	Arginine and proline metabolism	2/1106	61/7206	0.00629558073814
ko04930	Type II diabetes mellitus	16/1106	54/7206	0.00692721342619
ko03420	Nucleotide excision repair	1/1106	46/7206	0.00693348604561
ko00240	Pyrimidine metabolism	7/1106	110/7206	0.00705918983985
ko04015	Rap1 signaling pathway	59/1106	278/7206	0.00827174972365
ko05321	Inflammatory bowel disease (IBD)	2/1106	56/7206	0.00866959943291
ko03022	Basal transcription factors	1/1106	44/7206	0.0104255867435
ko05144	Malaria	1/1106	45/7206	0.0108017637879
ko00071	Fatty acid degradation	1/1106	45/7206	0.0108017637879
ko04140	Autophagy - animal	14/1106	164/7206	0.0115960213111
ko00280	Valine, leucine and isoleucine degradation	2/1106	54/7206	0.0126315411919
ko01200	Carbon metabolism	10/1106	128/7206	0.0133055360556
ko05418	Fluid shear stress and atherosclerosis	15/1106	173/7206	0.0135289595796
ko00561	Glycerolipid metabolism	3/1106	63/7206	0.0136846682463
ko00600	Sphingolipid metabolism	3/1106	63/7206	0.0136846682463
ko00310	Lysine degradation	4/1106	73/7206	0.0139927863581
ko04371	Apelin signaling pathway	39/1106	177/7206	0.0151483105487
ko04217	Necroptosis	16/1106	178/7206	0.0151758822737
ko05145	Toxoplasmosis	10/1106	126/7206	0.0174261197473
ko04138	Autophagy - yeast	5/1106	81/7206	0.0190568210324
ko04622	RIG-I-like receptor signaling pathway	3/1106	62/7206	0.0197369855422
ko05016	Huntington's disease	21/1106	215/7206	0.0207519364688
ko03410	Base excision repair	1/1106	38/7206	0.022960596165
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1106	100/7206	0.0241182300631
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1106	40/7206	0.0243862836319
ko05133	Pertussis	6/1106	87/7206	0.0243915710678
ko05217	Basal cell carcinoma	4/1106	68/7206	0.0270236508194
ko03320	PPAR signaling pathway	4/1106	69/7206	0.0274281929819
ko04973	Carbohydrate digestion and absorption	12/1106	42/7206	0.0284697023482
ko04668	TNF signaling pathway	10/1106	120/7206	0.0295767071889
ko04658	Th1 and Th2 cell differentiation	7/1106	96/7206	0.0310268046866
ko04115	p53 signaling pathway	5/1106	74/7206	0.0352592407687
ko00982	Drug metabolism - cytochrome P450	1/1106	37/7206	0.0355943642616
ko01524	Platinum drug resistance	5/1106	76/7206	0.035803208291
ko04620	Toll-like receptor signaling pathway	8/1106	100/7206	0.036416467154
ko04923	Regulation of lipolysis in adipocytes	19/1106	77/7206	0.0367462439658
ko00620	Pyruvate metabolism	2/1106	46/7206	0.0380481767441
ko00270	Cysteine and methionine metabolism	2/1106	47/7206	0.0391091308879
ko05214	Glioma	19/1106	79/7206	0.0399830161937
ko04912	GnRH signaling pathway	27/1106	122/7206	0.0422160061713
ko05131	Shigellosis	6/1106	82/7206	0.0440664686702
ko04974	Protein digestion and absorption	22/1106	96/7206	0.0453517906542
ko04626	Plant-pathogen interaction	6/1106	18/7206	0.0460151364076
ko04960	Aldosterone-regulated sodium reabsorption	11/1106	41/7206	0.0496489613342