ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 44/407 134/7206 6.30422609795e-23 ko04060 Cytokine-cytokine receptor interaction 46/407 191/7206 8.12117194351e-18 ko04064 NF-kappa B signaling pathway 31/407 96/7206 3.29883153381e-16 ko04621 NOD-like receptor signaling pathway 39/407 157/7206 9.8454749588e-16 ko05164 Influenza A 39/407 167/7206 9.1161551687e-15 ko05162 Measles 31/407 120/7206 3.16052719557e-13 ko05140 Leishmaniasis 24/407 75/7206 1.01856067316e-12 ko05168 Herpes simplex infection 37/407 182/7206 4.31045919929e-12 ko04620 Toll-like receptor signaling pathway 26/407 100/7206 2.34759490481e-11 ko05152 Tuberculosis 36/407 187/7206 4.49386902881e-11 ko04217 Necroptosis 35/407 178/7206 4.5586391663e-11 ko04668 TNF signaling pathway 28/407 120/7206 6.50112760669e-11 ko05161 Hepatitis B 34/407 173/7206 8.88075574461e-11 ko05145 Toxoplasmosis 28/407 126/7206 2.21835283504e-10 ko04659 Th17 cell differentiation 25/407 106/7206 5.54545861206e-10 ko05321 Inflammatory bowel disease (IBD) 18/407 56/7206 6.86571570379e-10 ko04610 Complement and coagulation cascades 21/407 79/7206 1.31929745831e-09 ko04650 Natural killer cell mediated cytotoxicity 23/407 97/7206 2.47187620763e-09 ko05150 Staphylococcus aureus infection 14/407 36/7206 3.26401756914e-09 ko04660 T cell receptor signaling pathway 26/407 124/7206 3.75657144674e-09 ko04630 Jak-STAT signaling pathway 26/407 132/7206 1.5049054159e-08 ko05167 Kaposi's sarcoma-associated herpesvirus infection 32/407 191/7206 2.04420650226e-08 ko05340 Primary immunodeficiency 12/407 30/7206 3.06747494813e-08 ko05133 Pertussis 20/407 87/7206 4.86807241104e-08 ko04672 Intestinal immune network for IgA production 13/407 37/7206 5.05803082527e-08 ko04658 Th1 and Th2 cell differentiation 21/407 96/7206 5.66183104919e-08 ko05323 Rheumatoid arthritis 20/407 89/7206 7.31447400228e-08 ko05144 Malaria 14/407 45/7206 8.9718258779e-08 ko04622 RIG-I-like receptor signaling pathway 16/407 62/7206 1.98082551765e-07 ko05142 Chagas disease (American trypanosomiasis) 23/407 130/7206 7.88079893267e-07 ko05160 Hepatitis C 25/407 153/7206 1.2264828307e-06 ko04662 B cell receptor signaling pathway 18/407 88/7206 1.4573080921e-06 ko04623 Cytosolic DNA-sensing pathway 12/407 41/7206 1.58541831843e-06 ko05320 Autoimmune thyroid disease 9/407 29/7206 1.94836147503e-05 ko04657 IL-17 signaling pathway 16/407 87/7206 2.32503213437e-05 ko05330 Allograft rejection 8/407 24/7206 3.18987691772e-05 ko04640 Hematopoietic cell lineage 13/407 64/7206 4.60149135532e-05 ko04933 AGE-RAGE signaling pathway in diabetic complications 20/407 135/7206 6.22545655947e-05 ko04062 Chemokine signaling pathway 26/407 201/7206 6.44324148339e-05 ko04612 Antigen processing and presentation 14/407 77/7206 8.56158780843e-05 ko04210 Apoptosis 24/407 180/7206 9.28045602313e-05 ko04145 Phagosome 22/407 162/7206 0.000103392025446 ko05132 Salmonella infection 16/407 98/7206 0.000104886956794 ko05134 Legionellosis 13/407 74/7206 0.000218832494805 ko05310 Asthma 6/407 17/7206 0.000227128208619 ko00120 Primary bile acid biosynthesis 6/407 20/7206 0.000615337652343 ko05131 Shigellosis 13/407 82/7206 0.00061804566335 ko05034 Alcoholism 3/407 238/7206 0.000882638148336 ko04670 Leukocyte transendothelial migration 19/407 151/7206 0.00094110995497 ko04664 Fc epsilon RI signaling pathway 12/407 77/7206 0.0011599053634 ko05166 HTLV-I infection 30/407 292/7206 0.00162416971543 ko05418 Fluid shear stress and atherosclerosis 20/407 173/7206 0.00214587260089 ko04724 Glutamatergic synapse 1/407 152/7206 0.00222798213384 ko05012 Parkinson's disease 1/407 155/7206 0.00226097645872 ko05332 Graft-versus-host disease 5/407 18/7206 0.00260323073962 ko04611 Platelet activation 19/407 163/7206 0.00276029135618 ko05169 Epstein-Barr virus infection 22/407 206/7206 0.00333001218612 ko05146 Amoebiasis 13/407 99/7206 0.00358707632571 ko04666 Fc gamma R-mediated phagocytosis 15/407 122/7206 0.00425936942588 ko00140 Steroid hormone biosynthesis 7/407 41/7206 0.00737212328083 ko04940 Type I diabetes mellitus 6/407 32/7206 0.00809579144417 ko05143 African trypanosomiasis 6/407 32/7206 0.00809579144417 ko05016 Huntington's disease 4/407 215/7206 0.0100755327157 ko01200 Carbon metabolism 1/407 128/7206 0.010307591159 ko04931 Insulin resistance 15/407 137/7206 0.0131631166226 ko04310 Wnt signaling pathway 3/407 181/7206 0.0134291703469 ko04360 Axon guidance 5/407 233/7206 0.0136581089904 ko04728 Dopaminergic synapse 3/407 185/7206 0.0139593507133 ko04151 PI3K-Akt signaling pathway 33/407 390/7206 0.0175060366875 ko04514 Cell adhesion molecules (CAMs) 14/407 130/7206 0.018976315203 ko04727 GABAergic synapse 1/407 110/7206 0.0209892299575 ko05032 Morphine addiction 1/407 110/7206 0.0209892299575 ko04972 Pancreatic secretion 1/407 111/7206 0.0210530528027 ko05020 Prion diseases 6/407 40/7206 0.0234856255393 ko04916 Melanogenesis 2/407 142/7206 0.0250774842475 ko04550 Signaling pathways regulating pluripotency of stem cells 3/407 165/7206 0.0255821296458 ko04144 Endocytosis 29/407 342/7206 0.0295886014112 ko04920 Adipocytokine signaling pathway 10/407 89/7206 0.0332683530698 ko05215 Prostate cancer 12/407 111/7206 0.0338290175507 ko05416 Viral myocarditis 7/407 55/7206 0.0339527004893 ko04713 Circadian entrainment 2/407 136/7206 0.0357819419375 ko05120 Epithelial cell signaling in Helicobacter pylori infection 10/407 92/7206 0.0385714564898 ko05200 Pathways in cancer 38/407 492/7206 0.0429255170298 ko04512 ECM-receptor interaction 9/407 79/7206 0.0430292512837 ko05010 Alzheimer's disease 5/407 202/7206 0.0440791651478 ko04260 Cardiac muscle contraction 1/407 98/7206 0.0441689308224 ko00190 Oxidative phosphorylation 2/407 127/7206 0.0489500148611