ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 126/622 423/7206 3.46045664249e-39 ko05033 Nicotine addiction 36/622 56/7206 2.91061150953e-25 ko04724 Glutamatergic synapse 58/622 152/7206 3.96545529642e-24 ko04713 Circadian entrainment 48/622 136/7206 1.79061804272e-18 ko04020 Calcium signaling pathway 68/622 265/7206 3.45726344523e-17 ko04728 Dopaminergic synapse 54/622 185/7206 1.90003891395e-16 ko04723 Retrograde endocannabinoid signaling 51/622 175/7206 1.47038296911e-15 ko05032 Morphine addiction 38/622 110/7206 1.64125434197e-14 ko04720 Long-term potentiation 34/622 99/7206 4.99413209494e-13 ko04727 GABAergic synapse 36/622 110/7206 5.37456790344e-13 ko05031 Amphetamine addiction 31/622 91/7206 6.96783852097e-12 ko04721 Synaptic vesicle cycle 28/622 80/7206 3.53175730801e-11 ko04726 Serotonergic synapse 38/622 137/7206 3.59553809222e-11 ko04921 Oxytocin signaling pathway 49/622 209/7206 4.15431563974e-11 ko04024 cAMP signaling pathway 59/622 279/7206 4.4556511276e-11 ko04911 Insulin secretion 33/622 117/7206 4.48065344931e-10 ko04970 Salivary secretion 29/622 95/7206 6.71590942508e-10 ko04261 Adrenergic signaling in cardiomyocytes 46/622 205/7206 7.98109054211e-10 ko05014 Amyotrophic lateral sclerosis (ALS) 25/622 74/7206 9.56058666776e-10 ko04725 Cholinergic synapse 38/622 160/7206 4.70532376462e-09 ko04022 cGMP-PKG signaling pathway 45/622 216/7206 1.70012834999e-08 ko04730 Long-term depression 24/622 78/7206 1.71124391112e-08 ko04971 Gastric acid secretion 24/622 98/7206 1.88728543588e-06 ko04925 Aldosterone synthesis and secretion 25/622 105/7206 2.01707113581e-06 ko04742 Taste transduction 18/622 61/7206 2.11217966454e-06 ko04745 Phototransduction - fly 13/622 38/7206 9.28024969316e-06 ko05168 Herpes simplex infection 2/622 182/7206 2.15336955254e-05 ko05030 Cocaine addiction 18/622 73/7206 3.2986130573e-05 ko04010 MAPK signaling pathway 50/622 321/7206 3.73999398617e-05 ko03040 Spliceosome 1/622 145/7206 6.30502593913e-05 ko04540 Gap junction 25/622 128/7206 8.57498766344e-05 ko04924 Renin secretion 19/622 86/7206 0.000101561897698 ko04514 Cell adhesion molecules (CAMs) 25/622 130/7206 0.000107545175764 ko05203 Viral carcinogenesis 8/622 277/7206 0.000171445503978 ko03010 Ribosome 1/622 129/7206 0.000193529801298 ko05322 Systemic lupus erythematosus 2/622 151/7206 0.000202175112081 ko04260 Cardiac muscle contraction 20/622 98/7206 0.00034871612964 ko04626 Plant-pathogen interaction 7/622 18/7206 0.000471169908543 ko04972 Pancreatic secretion 21/622 111/7206 0.000488278599597 ko04120 Ubiquitin mediated proteolysis 2/622 138/7206 0.000618776879121 ko04750 Inflammatory mediator regulation of TRP channels 22/622 122/7206 0.000848073153591 ko04630 Jak-STAT signaling pathway 2/622 132/7206 0.000894314111368 ko04070 Phosphatidylinositol signaling system 20/622 112/7206 0.0017322257072 ko04740 Olfactory transduction 16/622 80/7206 0.00182684550496 ko04360 Axon guidance 34/622 233/7206 0.00195048444902 ko04114 Oocyte meiosis 23/622 139/7206 0.00201650948995 ko05010 Alzheimer's disease 30/622 202/7206 0.00312042819262 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 15/622 79/7206 0.00349519240987 ko04922 Glucagon signaling pathway 21/622 128/7206 0.00370197235314 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/622 59/7206 0.00393593270861 ko04014 Ras signaling pathway 38/622 279/7206 0.00442101345412 ko05164 Influenza A 5/622 167/7206 0.00501036755535 ko04930 Type II diabetes mellitus 11/622 54/7206 0.00560070080698 ko04146 Peroxisome 1/622 89/7206 0.00648949807528 ko04621 NOD-like receptor signaling pathway 5/622 157/7206 0.00935518537699 ko04964 Proximal tubule bicarbonate reclamation 7/622 29/7206 0.0100167217411 ko04350 TGF-beta signaling pathway 2/622 103/7206 0.0117162541963 ko05162 Measles 3/622 120/7206 0.0126224930571 ko05161 Hepatitis B 6/622 173/7206 0.0126820446179 ko04550 Signaling pathways regulating pluripotency of stem cells 6/622 165/7206 0.0165902651243 ko04978 Mineral absorption 8/622 40/7206 0.0190367550962 ko04214 Apoptosis - fly 1/622 72/7206 0.0193599161416 ko04966 Collecting duct acid secretion 6/622 26/7206 0.0208263330517 ko04960 Aldosterone-regulated sodium reabsorption 8/622 41/7206 0.0219244395841 ko05169 Epstein-Barr virus infection 9/622 206/7206 0.0231935494657 ko00240 Pyrimidine metabolism 3/622 110/7206 0.0242858265992 ko04973 Carbohydrate digestion and absorption 8/622 42/7206 0.0251082418265 ko04915 Estrogen signaling pathway 19/622 131/7206 0.0259938696153 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/622 14/7206 0.0273257039521 ko04072 Phospholipase D signaling pathway 26/622 197/7206 0.0277898323415 ko04657 IL-17 signaling pathway 2/622 87/7206 0.0323156860863 ko04668 TNF signaling pathway 4/622 120/7206 0.0325501526199 ko04141 Protein processing in endoplasmic reticulum 8/622 184/7206 0.0329714781548 ko05202 Transcriptional misregulation in cancer 8/622 188/7206 0.0338025264634 ko00512 Mucin type O-glycan biosynthesis 6/622 29/7206 0.0345003712084 ko03013 RNA transport 7/622 166/7206 0.0359957661617 ko05200 Pathways in cancer 30/622 492/7206 0.0374454724093 ko04330 Notch signaling pathway 1/622 62/7206 0.0408831190377 ko04210 Apoptosis 8/622 180/7206 0.0428836386468 ko05214 Glioma 12/622 79/7206 0.0438532675342 ko05230 Central carbon metabolism in cancer 2/622 81/7206 0.0450286753221 ko04510 Focal adhesion 12/622 240/7206 0.0457650485605