ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	195/1143	423/7206	2.51555411684e-52
ko04724	Glutamatergic synapse	88/1143	152/7206	4.93779424855e-33
ko05033	Nicotine addiction	49/1143	56/7206	2.02706055479e-32
ko05032	Morphine addiction	68/1143	110/7206	3.9844967346e-28
ko04727	GABAergic synapse	66/1143	110/7206	3.0307803737e-26
ko04713	Circadian entrainment	74/1143	136/7206	1.45272958159e-25
ko04721	Synaptic vesicle cycle	51/1143	80/7206	2.99563116548e-22
ko04725	Cholinergic synapse	77/1143	160/7206	3.96047639411e-22
ko04728	Dopaminergic synapse	83/1143	185/7206	2.86990636658e-21
ko04723	Retrograde endocannabinoid signaling	77/1143	175/7206	3.51582010709e-19
ko04024	cAMP signaling pathway	104/1143	279/7206	5.74855719482e-19
ko04020	Calcium signaling pathway	95/1143	265/7206	5.30078037578e-16
ko04744	Phototransduction	27/1143	36/7206	4.32073290968e-15
ko04726	Serotonergic synapse	60/1143	137/7206	4.41692998794e-15
ko04742	Taste transduction	35/1143	61/7206	1.16896992647e-13
ko04911	Insulin secretion	52/1143	117/7206	1.50379738382e-13
ko04921	Oxytocin signaling pathway	75/1143	209/7206	6.64079123548e-13
ko04720	Long-term potentiation	45/1143	99/7206	2.55674157233e-12
ko05031	Amphetamine addiction	42/1143	91/7206	7.43318633159e-12
ko04261	Adrenergic signaling in cardiomyocytes	70/1143	205/7206	7.62261577472e-11
ko03040	Spliceosome	2/1143	145/7206	6.4919095561e-09
ko04970	Salivary secretion	38/1143	95/7206	1.10906977237e-08
ko05030	Cocaine addiction	30/1143	73/7206	1.92383791273e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1143	74/7206	2.75204444965e-07
ko05203	Viral carcinogenesis	16/1143	277/7206	3.39218502387e-07
ko04360	Axon guidance	67/1143	233/7206	3.82991508977e-07
ko04740	Olfactory transduction	31/1143	80/7206	5.76662269533e-07
ko04925	Aldosterone synthesis and secretion	37/1143	105/7206	1.02784236005e-06
ko05322	Systemic lupus erythematosus	5/1143	151/7206	1.34643932891e-06
ko04022	cGMP-PKG signaling pathway	62/1143	216/7206	1.56356765523e-06
ko04060	Cytokine-cytokine receptor interaction	9/1143	191/7206	2.64479416599e-06
ko04971	Gastric acid secretion	34/1143	98/7206	4.04735436823e-06
ko03013	RNA transport	7/1143	166/7206	4.23379170383e-06
ko04070	Phosphatidylinositol signaling system	37/1143	112/7206	5.44561799909e-06
ko05168	Herpes simplex infection	9/1143	182/7206	7.22533255698e-06
ko04966	Collecting duct acid secretion	14/1143	26/7206	8.67601268253e-06
ko04010	MAPK signaling pathway	81/1143	321/7206	1.01554496649e-05
ko04514	Cell adhesion molecules (CAMs)	40/1143	130/7206	1.61098820509e-05
ko04072	Phospholipase D signaling pathway	55/1143	197/7206	1.61929245092e-05
ko04120	Ubiquitin mediated proteolysis	6/1143	138/7206	3.06334949724e-05
ko04924	Renin secretion	29/1143	86/7206	3.71357700485e-05
ko05164	Influenza A	9/1143	167/7206	3.89413638368e-05
ko04621	NOD-like receptor signaling pathway	8/1143	157/7206	5.39436349006e-05
ko04730	Long-term depression	27/1143	78/7206	5.5376925351e-05
ko04141	Protein processing in endoplasmic reticulum	11/1143	184/7206	5.62094933272e-05
ko04540	Gap junction	38/1143	128/7206	7.08105974896e-05
ko04745	Phototransduction - fly	16/1143	38/7206	9.97089817163e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1143	79/7206	0.000144072942197
ko05110	Vibrio cholerae infection	22/1143	63/7206	0.000174258989612
ko04110	Cell cycle	8/1143	145/7206	0.000199395516139
ko04915	Estrogen signaling pathway	37/1143	131/7206	0.000256678113836
ko04610	Complement and coagulation cascades	2/1143	79/7206	0.000266926616061
ko03008	Ribosome biogenesis in eukaryotes	2/1143	79/7206	0.000266926616061
ko04014	Ras signaling pathway	67/1143	279/7206	0.000302337252671
ko04750	Inflammatory mediator regulation of TRP channels	35/1143	122/7206	0.00037630174808
ko05140	Leishmaniasis	2/1143	75/7206	0.000390811592396
ko04972	Pancreatic secretion	32/1143	111/7206	0.000538520401086
ko05414	Dilated cardiomyopathy	32/1143	112/7206	0.000587368816816
ko04064	NF-kappa B signaling pathway	4/1143	96/7206	0.000601375435326
ko04260	Cardiac muscle contraction	29/1143	98/7206	0.000661591818518
ko04923	Regulation of lipolysis in adipocytes	24/1143	77/7206	0.000755491658197
ko04626	Plant-pathogen interaction	9/1143	18/7206	0.00076726051431
ko04612	Antigen processing and presentation	3/1143	77/7206	0.00154316721337
ko05205	Proteoglycans in cancer	25/1143	271/7206	0.00163517625516
ko05169	Epstein-Barr virus infection	17/1143	206/7206	0.00181987321607
ko00590	Arachidonic acid metabolism	1/1143	52/7206	0.00200898095215
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1143	14/7206	0.0030428417516
ko05161	Hepatitis B	14/1143	173/7206	0.00307079629386
ko05162	Measles	8/1143	120/7206	0.00350594936903
ko00240	Pyrimidine metabolism	7/1143	110/7206	0.00362143229921
ko04146	Peroxisome	5/1143	89/7206	0.00510494222718
ko05144	Malaria	1/1143	45/7206	0.00679667648678
ko00071	Fatty acid degradation	1/1143	45/7206	0.00679667648678
ko03420	Nucleotide excision repair	1/1143	46/7206	0.00701613576181
ko00562	Inositol phosphate metabolism	24/1143	89/7206	0.00775671277112
ko04976	Bile secretion	22/1143	80/7206	0.00798988788653
ko05231	Choline metabolism in cancer	33/1143	134/7206	0.00816231091829
ko00480	Glutathione metabolism	2/1143	55/7206	0.00852255575421
ko04350	TGF-beta signaling pathway	7/1143	103/7206	0.00922415143592
ko00310	Lysine degradation	4/1143	73/7206	0.00983225024107
ko03022	Basal transcription factors	1/1143	44/7206	0.0108512610114
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1143	59/7206	0.0110147364628
ko04930	Type II diabetes mellitus	16/1143	54/7206	0.013168021992
ko04622	RIG-I-like receptor signaling pathway	3/1143	62/7206	0.0134715873538
ko04214	Apoptosis - fly	4/1143	72/7206	0.0138957868371
ko04062	Chemokine signaling pathway	45/1143	201/7206	0.0139776599623
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1143	40/7206	0.0152476055476
ko04722	Neurotrophin signaling pathway	37/1143	160/7206	0.0155225661907
ko04371	Apelin signaling pathway	40/1143	177/7206	0.0163408515248
ko05133	Pertussis	6/1143	87/7206	0.0177293546727
ko05230	Central carbon metabolism in cancer	21/1143	81/7206	0.0203610275744
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1143	15/7206	0.0217008369858
ko00630	Glyoxylate and dicarboxylate metabolism	1/1143	38/7206	0.023151561589
ko04912	GnRH signaling pathway	29/1143	122/7206	0.0234794259241
ko03018	RNA degradation	6/1143	84/7206	0.0239952261857
ko05145	Toxoplasmosis	11/1143	126/7206	0.0262015047459
ko05321	Inflammatory bowel disease (IBD)	3/1143	56/7206	0.0268494470868
ko05166	HTLV-I infection	33/1143	292/7206	0.0273216112933
ko05214	Glioma	20/1143	79/7206	0.0288310545298
ko04071	Sphingolipid signaling pathway	36/1143	162/7206	0.0293708012827
ko05131	Shigellosis	6/1143	82/7206	0.0323940033302
ko04973	Carbohydrate digestion and absorption	12/1143	42/7206	0.0324941992005
ko04115	p53 signaling pathway	5/1143	74/7206	0.0356618245798
ko04015	Rap1 signaling pathway	57/1143	278/7206	0.0360031890215
ko05213	Endometrial cancer	16/1143	62/7206	0.0366047353552
ko05016	Huntington's disease	23/1143	215/7206	0.0366287099636
ko04964	Proximal tubule bicarbonate reclamation	9/1143	29/7206	0.0374242706293
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1143	182/7206	0.0401003589247
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1143	92/7206	0.0430417555235
ko04114	Oocyte meiosis	31/1143	139/7206	0.0452912468061
ko03320	PPAR signaling pathway	5/1143	69/7206	0.0470599522014
ko04658	Th1 and Th2 cell differentiation	8/1143	96/7206	0.0475348467515
ko04510	Focal adhesion	27/1143	240/7206	0.0478193716463