ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	173/1084	423/7206	7.99347857953e-41
ko05033	Nicotine addiction	44/1084	56/7206	2.65655925013e-26
ko05032	Morphine addiction	64/1084	110/7206	9.32740319137e-26
ko04724	Glutamatergic synapse	77/1084	152/7206	1.90228835513e-25
ko04727	GABAergic synapse	62/1084	110/7206	5.95980825392e-24
ko04728	Dopaminergic synapse	81/1084	185/7206	1.83434736482e-21
ko04721	Synaptic vesicle cycle	49/1084	80/7206	2.38774270111e-21
ko04725	Cholinergic synapse	70/1084	160/7206	1.1631683771e-18
ko04713	Circadian entrainment	63/1084	136/7206	1.91972204342e-18
ko04024	cAMP signaling pathway	98/1084	279/7206	2.4972359679e-17
ko04723	Retrograde endocannabinoid signaling	71/1084	175/7206	9.57061988618e-17
ko04744	Phototransduction	27/1084	36/7206	1.10392078859e-15
ko04726	Serotonergic synapse	55/1084	137/7206	5.17053706099e-13
ko04742	Taste transduction	32/1084	61/7206	8.16521797051e-12
ko04921	Oxytocin signaling pathway	70/1084	209/7206	1.15301960947e-11
ko04020	Calcium signaling pathway	82/1084	265/7206	2.93730330456e-11
ko04911	Insulin secretion	45/1084	117/7206	3.77844743796e-10
ko05031	Amphetamine addiction	38/1084	91/7206	5.582343283e-10
ko04261	Adrenergic signaling in cardiomyocytes	65/1084	205/7206	9.96531903262e-10
ko03040	Spliceosome	2/1084	145/7206	2.58927161698e-08
ko03010	Ribosome	1/1084	129/7206	2.84463679778e-08
ko04966	Collecting duct acid secretion	16/1084	26/7206	7.39557935831e-08
ko05322	Systemic lupus erythematosus	3/1084	151/7206	1.03580753565e-07
ko04720	Long-term potentiation	36/1084	99/7206	1.18513066997e-07
ko05030	Cocaine addiction	29/1084	73/7206	2.28643936476e-07
ko05203	Viral carcinogenesis	15/1084	277/7206	4.93567903562e-07
ko05168	Herpes simplex infection	7/1084	182/7206	1.51996230188e-06
ko04970	Salivary secretion	32/1084	95/7206	4.2599754649e-06
ko04925	Aldosterone synthesis and secretion	34/1084	105/7206	6.22085712912e-06
ko03013	RNA transport	7/1084	166/7206	1.31869060109e-05
ko04120	Ubiquitin mediated proteolysis	5/1084	138/7206	1.97126395441e-05
ko04022	cGMP-PKG signaling pathway	56/1084	216/7206	2.59115294898e-05
ko04971	Gastric acid secretion	31/1084	98/7206	2.6124076078e-05
ko04010	MAPK signaling pathway	76/1084	321/7206	2.90539281571e-05
ko04060	Cytokine-cytokine receptor interaction	10/1084	191/7206	3.19205719772e-05
ko04070	Phosphatidylinositol signaling system	34/1084	112/7206	4.19680117015e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1084	74/7206	4.85566962811e-05
ko04915	Estrogen signaling pathway	36/1084	131/7206	0.00018634641964
ko04141	Protein processing in endoplasmic reticulum	11/1084	184/7206	0.000217291686345
ko05110	Vibrio cholerae infection	21/1084	63/7206	0.000248608578431
ko04922	Glucagon signaling pathway	35/1084	128/7206	0.000257842859606
ko04730	Long-term depression	24/1084	78/7206	0.000355799668407
ko04621	NOD-like receptor signaling pathway	9/1084	157/7206	0.000407617892131
ko03008	Ribosome biogenesis in eukaryotes	2/1084	79/7206	0.000414324928481
ko04626	Plant-pathogen interaction	9/1084	18/7206	0.000512832053625
ko04260	Cardiac muscle contraction	28/1084	98/7206	0.000517347403716
ko04964	Proximal tubule bicarbonate reclamation	12/1084	29/7206	0.000545477514842
ko04110	Cell cycle	8/1084	145/7206	0.00057039673105
ko04612	Antigen processing and presentation	2/1084	77/7206	0.000610288280562
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1084	59/7206	0.00075709852954
ko04745	Phototransduction - fly	14/1084	38/7206	0.000780318964938
ko05140	Leishmaniasis	2/1084	75/7206	0.000911985100331
ko05164	Influenza A	11/1084	167/7206	0.000963652724527
ko04972	Pancreatic secretion	30/1084	111/7206	0.00110522580907
ko04514	Cell adhesion molecules (CAMs)	34/1084	130/7206	0.00110633013845
ko04072	Phospholipase D signaling pathway	47/1084	197/7206	0.00110803758673
ko04014	Ras signaling pathway	62/1084	279/7206	0.0011116442731
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/1084	79/7206	0.00125467937597
ko04740	Olfactory transduction	23/1084	80/7206	0.00142412500088
ko05166	HTLV-I infection	26/1084	292/7206	0.00192028097778
ko04924	Renin secretion	24/1084	86/7206	0.00202014846015
ko05169	Epstein-Barr virus infection	16/1084	206/7206	0.00205003266559
ko00520	Amino sugar and nucleotide sugar metabolism	1/1084	55/7206	0.00209960755018
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1084	14/7206	0.00222056942929
ko04610	Complement and coagulation cascades	3/1084	79/7206	0.0023295158645
ko04360	Axon guidance	52/1084	233/7206	0.00272546150625
ko05414	Dilated cardiomyopathy	29/1084	112/7206	0.00297831281926
ko04064	NF-kappa B signaling pathway	5/1084	96/7206	0.00380278826645
ko04371	Apelin signaling pathway	41/1084	177/7206	0.00381358836565
ko04976	Bile secretion	22/1084	80/7206	0.00398604023817
ko04750	Inflammatory mediator regulation of TRP channels	30/1084	122/7206	0.0047437640042
ko04923	Regulation of lipolysis in adipocytes	21/1084	77/7206	0.00559340703149
ko04930	Type II diabetes mellitus	16/1084	54/7206	0.006151733985
ko04330	Notch signaling pathway	2/1084	62/7206	0.00631473986387
ko05162	Measles	8/1084	120/7206	0.00664765994297
ko00240	Pyrimidine metabolism	7/1084	110/7206	0.00698788825082
ko05161	Hepatitis B	14/1084	173/7206	0.00705096373964
ko04152	AMPK signaling pathway	37/1084	161/7206	0.00707051958794
ko05205	Proteoglycans in cancer	26/1084	271/7206	0.00918900922077
ko04710	Circadian rhythm	13/1084	43/7206	0.00938286665797
ko03022	Basal transcription factors	1/1084	44/7206	0.0104885360177
ko03420	Nucleotide excision repair	1/1084	46/7206	0.0109903387208
ko05230	Central carbon metabolism in cancer	21/1084	81/7206	0.0112096192462
ko05145	Toxoplasmosis	9/1084	126/7206	0.0112535453521
ko00290	Valine, leucine and isoleucine biosynthesis	3/1084	4/7206	0.0120554487441
ko00280	Valine, leucine and isoleucine degradation	2/1084	54/7206	0.0127645657278
ko00480	Glutathione metabolism	2/1084	55/7206	0.0127689764862
ko05321	Inflammatory bowel disease (IBD)	2/1084	56/7206	0.0130630403917
ko04658	Th1 and Th2 cell differentiation	6/1084	96/7206	0.0136370753241
ko00010	Glycolysis / Gluconeogenesis	19/1084	74/7206	0.0140765011285
ko00562	Inositol phosphate metabolism	22/1084	89/7206	0.0159260045419
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1084	100/7206	0.016106718229
ko04510	Focal adhesion	23/1084	240/7206	0.0165309092625
ko04350	TGF-beta signaling pathway	7/1084	103/7206	0.0173319822713
ko00590	Arachidonic acid metabolism	2/1084	52/7206	0.0184257276567
ko04622	RIG-I-like receptor signaling pathway	3/1084	62/7206	0.0195671664287
ko04214	Apoptosis - fly	4/1084	72/7206	0.0196807957
ko05231	Choline metabolism in cancer	30/1084	134/7206	0.0202777414626
ko04115	p53 signaling pathway	4/1084	74/7206	0.0204323261721
ko04540	Gap junction	29/1084	128/7206	0.0237086545706
ko04146	Peroxisome	6/1084	89/7206	0.0246406955273
ko04071	Sphingolipid signaling pathway	35/1084	162/7206	0.0254205377481
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1084	92/7206	0.026184251466
ko00680	Methane metabolism	10/1084	34/7206	0.0279948861362
ko04657	IL-17 signaling pathway	6/1084	87/7206	0.0333685210743
ko05133	Pertussis	6/1084	87/7206	0.0333685210743
ko04062	Chemokine signaling pathway	41/1084	201/7206	0.035451832578
ko05202	Transcriptional misregulation in cancer	18/1084	188/7206	0.0379023383703
ko05217	Basal cell carcinoma	4/1084	68/7206	0.0385773126666
ko05219	Bladder cancer	2/1084	48/7206	0.0395175538743
ko05206	MicroRNAs in cancer	17/1084	177/7206	0.0425150826255
ko04217	Necroptosis	17/1084	178/7206	0.0428412739549
ko03018	RNA degradation	6/1084	84/7206	0.0445749228785
ko04960	Aldosterone-regulated sodium reabsorption	11/1084	41/7206	0.0459318044855
ko00310	Lysine degradation	5/1084	73/7206	0.0480590732683