ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 32/464 191/7206 4.34738375025e-07 ko04650 Natural killer cell mediated cytotoxicity 20/464 97/7206 2.61347486287e-06 ko04380 Osteoclast differentiation 23/464 134/7206 1.24470235512e-05 ko05340 Primary immunodeficiency 9/464 30/7206 7.44447445282e-05 ko04658 Th1 and Th2 cell differentiation 17/464 96/7206 0.000113503682452 ko04610 Complement and coagulation cascades 15/464 79/7206 0.000126740902227 ko00590 Arachidonic acid metabolism 11/464 52/7206 0.000379117558862 ko04659 Th17 cell differentiation 17/464 106/7206 0.000390781387069 ko05152 Tuberculosis 25/464 187/7206 0.000413064701891 ko05164 Influenza A 23/464 167/7206 0.000572169912042 ko05034 Alcoholism 4/464 238/7206 0.000708605279505 ko00592 alpha-Linolenic acid metabolism 6/464 19/7206 0.000909705234861 ko00140 Steroid hormone biosynthesis 9/464 41/7206 0.000966375210031 ko00120 Primary bile acid biosynthesis 6/464 20/7206 0.00122979389179 ko05145 Toxoplasmosis 18/464 126/7206 0.00131358157321 ko04621 NOD-like receptor signaling pathway 21/464 157/7206 0.00136458704674 ko04710 Circadian rhythm 9/464 43/7206 0.00138670822789 ko03040 Spliceosome 1/464 145/7206 0.00158707705442 ko05150 Staphylococcus aureus infection 8/464 36/7206 0.00169344128401 ko03013 RNA transport 2/464 166/7206 0.00203963560791 ko04672 Intestinal immune network for IgA production 8/464 37/7206 0.00204142812235 ko04660 T cell receptor signaling pathway 17/464 124/7206 0.0026036202654 ko05321 Inflammatory bowel disease (IBD) 10/464 56/7206 0.00270739550827 ko03010 Ribosome 1/464 129/7206 0.00318434688102 ko04662 B cell receptor signaling pathway 13/464 88/7206 0.00389627143677 ko00350 Tyrosine metabolism 7/464 33/7206 0.00432566984385 ko00051 Fructose and mannose metabolism 8/464 42/7206 0.00470318344379 ko00565 Ether lipid metabolism 8/464 42/7206 0.00470318344379 ko04611 Platelet activation 20/464 163/7206 0.00520464583995 ko04070 Phosphatidylinositol signaling system 15/464 112/7206 0.00575668354874 ko04110 Cell cycle 2/464 145/7206 0.00593863802477 ko05167 Kaposi's sarcoma-associated herpesvirus infection 22/464 191/7206 0.00672747918596 ko04933 AGE-RAGE signaling pathway in diabetic complications 17/464 135/7206 0.0069488866467 ko04666 Fc gamma R-mediated phagocytosis 16/464 122/7206 0.00754300634477 ko05140 Leishmaniasis 11/464 75/7206 0.00807506597167 ko04217 Necroptosis 20/464 178/7206 0.0127885350557 ko05162 Measles 15/464 120/7206 0.0127905907099 ko04960 Aldosterone-regulated sodium reabsorption 7/464 41/7206 0.01460595658 ko04068 FoxO signaling pathway 19/464 167/7206 0.0152214910211 ko04664 Fc epsilon RI signaling pathway 11/464 77/7206 0.0155965792688 ko04022 cGMP-PKG signaling pathway 23/464 216/7206 0.0158736696418 ko00360 Phenylalanine metabolism 4/464 17/7206 0.0206324829348 ko00950 Isoquinoline alkaloid biosynthesis 3/464 10/7206 0.0226464761857 ko05133 Pertussis 11/464 87/7206 0.026109456935 ko04670 Leukocyte transendothelial migration 17/464 151/7206 0.026966989536 ko04514 Cell adhesion molecules (CAMs) 15/464 130/7206 0.027761799518 ko04630 Jak-STAT signaling pathway 15/464 132/7206 0.0295195032925 ko04111 Cell cycle - yeast 1/464 90/7206 0.0297645888761 ko04391 Hippo signaling pathway - fly 1/464 90/7206 0.0297645888761 ko03015 mRNA surveillance pathway 1/464 93/7206 0.0303814785531 ko05231 Choline metabolism in cancer 15/464 134/7206 0.0316145965254 ko00564 Glycerophospholipid metabolism 12/464 99/7206 0.0349492992482 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/464 5/7206 0.036321287315 ko04750 Inflammatory mediator regulation of TRP channels 14/464 122/7206 0.0372245424803 ko04072 Phospholipase D signaling pathway 20/464 197/7206 0.0384597418855 ko04137 Mitophagy - animal 10/464 82/7206 0.0409629384842 ko04925 Aldosterone synthesis and secretion 12/464 105/7206 0.044038666258 ko05160 Hepatitis C 16/464 153/7206 0.0459374731264 ko04711 Circadian rhythm - fly 3/464 13/7206 0.04676000553