ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 63/217 423/7206 3.50221510132e-28 ko05033 Nicotine addiction 16/217 56/7206 3.78004950369e-12 ko04724 Glutamatergic synapse 23/217 152/7206 1.0801247388e-10 ko04742 Taste transduction 15/217 61/7206 1.94030038817e-10 ko04024 cAMP signaling pathway 28/217 279/7206 1.51114631662e-08 ko04713 Circadian entrainment 18/217 136/7206 1.07807925995e-07 ko05032 Morphine addiction 16/217 110/7206 1.49761930996e-07 ko04911 Insulin secretion 15/217 117/7206 1.94648348898e-06 ko04726 Serotonergic synapse 16/217 137/7206 3.08645223554e-06 ko04723 Retrograde endocannabinoid signaling 18/217 175/7206 4.66596416841e-06 ko04727 GABAergic synapse 14/217 110/7206 4.71546325663e-06 ko04020 Calcium signaling pathway 22/217 265/7206 1.37792244805e-05 ko04972 Pancreatic secretion 13/217 111/7206 2.58645598265e-05 ko05031 Amphetamine addiction 11/217 91/7206 8.16497654535e-05 ko04725 Cholinergic synapse 15/217 160/7206 8.76687014606e-05 ko04970 Salivary secretion 11/217 95/7206 0.00012122283491 ko04514 Cell adhesion molecules (CAMs) 13/217 130/7206 0.000135987692978 ko04921 Oxytocin signaling pathway 17/217 209/7206 0.000174780796242 ko05014 Amyotrophic lateral sclerosis (ALS) 9/217 74/7206 0.000348070449731 ko04728 Dopaminergic synapse 15/217 185/7206 0.000436660930667 ko04971 Gastric acid secretion 10/217 98/7206 0.000688999612215 ko04720 Long-term potentiation 10/217 99/7206 0.000746628806835 ko04022 cGMP-PKG signaling pathway 16/217 216/7206 0.000768581118743 ko04924 Renin secretion 9/217 86/7206 0.00106014198237 ko04925 Aldosterone synthesis and secretion 10/217 105/7206 0.00118188070628 ko05030 Cocaine addiction 8/217 73/7206 0.00148334745212 ko04964 Proximal tubule bicarbonate reclamation 5/217 29/7206 0.0015556932655 ko04961 Endocrine and other factor-regulated calcium reabsorption 7/217 59/7206 0.00183732488104 ko04730 Long-term depression 8/217 78/7206 0.00227563127622 ko04360 Axon guidance 15/217 233/7206 0.00510159965857 ko04270 Vascular smooth muscle contraction 11/217 154/7206 0.00662606297789 ko04721 Synaptic vesicle cycle 7/217 80/7206 0.0100650377431 ko04976 Bile secretion 7/217 80/7206 0.0100650377431 ko04918 Thyroid hormone synthesis 7/217 86/7206 0.0146441571933 ko04540 Gap junction 9/217 128/7206 0.0148735343368 ko05016 Huntington's disease 1/217 215/7206 0.0227562112789 ko04010 MAPK signaling pathway 17/217 321/7206 0.0274257677757 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/217 1/7206 0.0301137940605 ko04750 Inflammatory mediator regulation of TRP channels 8/217 122/7206 0.0305132593498 ko04740 Olfactory transduction 6/217 80/7206 0.0329853244379 ko04261 Adrenergic signaling in cardiomyocytes 12/217 205/7206 0.0337886209021 ko04960 Aldosterone-regulated sodium reabsorption 4/217 41/7206 0.0339488531568 ko05168 Herpes simplex infection 1/217 182/7206 0.0455101010399