ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04724	Glutamatergic synapse	73/668	152/7206	3.4431319469e-36
ko04080	Neuroactive ligand-receptor interaction	126/668	423/7206	9.2107597303e-36
ko05033	Nicotine addiction	41/668	56/7206	6.08882833175e-31
ko04728	Dopaminergic synapse	68/668	185/7206	3.65131570976e-25
ko04713	Circadian entrainment	56/668	136/7206	1.02548612057e-23
ko05032	Morphine addiction	50/668	110/7206	1.24916271258e-23
ko04727	GABAergic synapse	49/668	110/7206	1.07677108095e-22
ko04723	Retrograde endocannabinoid signaling	61/668	175/7206	2.91941361627e-21
ko05031	Amphetamine addiction	36/668	91/7206	5.58864577636e-15
ko04024	cAMP signaling pathway	69/668	279/7206	6.81955025957e-15
ko04720	Long-term potentiation	36/668	99/7206	1.20279441341e-13
ko04721	Synaptic vesicle cycle	32/668	80/7206	1.29977130309e-13
ko04020	Calcium signaling pathway	64/668	265/7206	2.30021454216e-13
ko04911	Insulin secretion	39/668	117/7206	2.92503078638e-13
ko04726	Serotonergic synapse	42/668	137/7206	8.73334091082e-13
ko04725	Cholinergic synapse	46/668	160/7206	9.22732987513e-13
ko04261	Adrenergic signaling in cardiomyocytes	53/668	205/7206	1.73227297165e-12
ko04921	Oxytocin signaling pathway	53/668	209/7206	3.94009498386e-12
ko04010	MAPK signaling pathway	68/668	321/7206	3.59305429388e-11
ko04970	Salivary secretion	31/668	95/7206	1.56363025241e-10
ko05030	Cocaine addiction	26/668	73/7206	5.55083380354e-10
ko05014	Amyotrophic lateral sclerosis (ALS)	25/668	74/7206	4.24309120535e-09
ko04925	Aldosterone synthesis and secretion	29/668	105/7206	4.38897693981e-08
ko04972	Pancreatic secretion	30/668	111/7206	4.40298364382e-08
ko04742	Taste transduction	20/668	61/7206	2.67918841887e-07
ko05203	Viral carcinogenesis	5/668	277/7206	4.22621935153e-07
ko04971	Gastric acid secretion	26/668	98/7206	5.22564715973e-07
ko04730	Long-term depression	22/668	78/7206	1.2782923107e-06
ko04060	Cytokine-cytokine receptor interaction	2/668	191/7206	2.95504575938e-06
ko04022	cGMP-PKG signaling pathway	42/668	216/7206	3.47924414601e-06
ko04260	Cardiac muscle contraction	24/668	98/7206	6.6030414143e-06
ko04514	Cell adhesion molecules (CAMs)	29/668	130/7206	8.39587969325e-06
ko04072	Phospholipase D signaling pathway	38/668	197/7206	9.33939031328e-06
ko03040	Spliceosome	1/668	145/7206	1.71372242487e-05
ko04014	Ras signaling pathway	47/668	279/7206	4.94955615205e-05
ko04915	Estrogen signaling pathway	27/668	131/7206	5.47524499366e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	19/668	79/7206	7.81123313956e-05
ko05168	Herpes simplex infection	4/668	182/7206	0.000226255744784
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/668	59/7206	0.000226865218302
ko04924	Renin secretion	19/668	86/7206	0.000259575546929
ko04015	Rap1 signaling pathway	44/668	278/7206	0.000432976959903
ko04745	Phototransduction - fly	11/668	38/7206	0.000466394256711
ko04360	Axon guidance	38/668	233/7206	0.000496429526426
ko05169	Epstein-Barr virus infection	6/668	206/7206	0.000544623103244
ko05164	Influenza A	4/668	167/7206	0.000627787197166
ko04070	Phosphatidylinositol signaling system	22/668	112/7206	0.000728744024815
ko04110	Cell cycle	3/668	145/7206	0.000758198594467
ko04964	Proximal tubule bicarbonate reclamation	9/668	29/7206	0.000875841984807
ko04973	Carbohydrate digestion and absorption	11/668	42/7206	0.0011773164027
ko04540	Gap junction	23/668	128/7206	0.00176097631488
ko05322	Systemic lupus erythematosus	4/668	151/7206	0.00250445119807
ko04550	Signaling pathways regulating pluripotency of stem cells	5/668	165/7206	0.00258433383034
ko04740	Olfactory transduction	16/668	80/7206	0.00277212056971
ko05034	Alcoholism	36/668	238/7206	0.00291915463342
ko04960	Aldosterone-regulated sodium reabsorption	10/668	41/7206	0.00345808802409
ko05231	Choline metabolism in cancer	23/668	134/7206	0.00367917735149
ko05414	Dilated cardiomyopathy	20/668	112/7206	0.00437865109545
ko04744	Phototransduction	9/668	36/7206	0.00457077582775
ko04071	Sphingolipid signaling pathway	26/668	162/7206	0.00552196531885
ko05162	Measles	3/668	120/7206	0.00622125380722
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/668	14/7206	0.00663734585178
ko04120	Ubiquitin mediated proteolysis	4/668	138/7206	0.0068087262667
ko04918	Thyroid hormone synthesis	16/668	86/7206	0.00723144702049
ko04932	Non-alcoholic fatty liver disease (NAFLD)	7/668	182/7206	0.00891684682514
ko04612	Antigen processing and presentation	1/668	77/7206	0.00897016254463
ko04140	Autophagy - animal	6/668	164/7206	0.00906423850351
ko04630	Jak-STAT signaling pathway	4/668	132/7206	0.00918550798434
ko05010	Alzheimer's disease	30/668	202/7206	0.0091923493696
ko04750	Inflammatory mediator regulation of TRP channels	20/668	122/7206	0.0108109234773
ko04666	Fc gamma R-mediated phagocytosis	20/668	122/7206	0.0108109234773
ko00240	Pyrimidine metabolism	3/668	110/7206	0.0121096018157
ko04214	Apoptosis - fly	1/668	72/7206	0.0130362834013
ko05205	Proteoglycans in cancer	14/668	271/7206	0.0139991407074
ko04930	Type II diabetes mellitus	11/668	54/7206	0.0146018973204
ko04621	NOD-like receptor signaling pathway	6/668	157/7206	0.0168323273816
ko04371	Apelin signaling pathway	26/668	177/7206	0.0173586020382
ko04976	Bile secretion	14/668	80/7206	0.0180228894257
ko04141	Protein processing in endoplasmic reticulum	8/668	184/7206	0.01942727262
ko03013	RNA transport	7/668	166/7206	0.0205456223568
ko04626	Plant-pathogen interaction	5/668	18/7206	0.020818708083
ko04217	Necroptosis	8/668	178/7206	0.0251234736477
ko04330	Notch signaling pathway	1/668	62/7206	0.0276978657334
ko04978	Mineral absorption	8/668	40/7206	0.0279757807875
ko04966	Collecting duct acid secretion	6/668	26/7206	0.0285622878349
ko03008	Ribosome biogenesis in eukaryotes	2/668	79/7206	0.0313735353048
ko05215	Prostate cancer	4/668	111/7206	0.0320738268232
ko04137	Mitophagy - animal	2/668	82/7206	0.0323143492557
ko05410	Hypertrophic cardiomyopathy (HCM)	16/668	100/7206	0.034446275996
ko04150	mTOR signaling pathway	9/668	184/7206	0.0384198612424
ko04912	GnRH signaling pathway	18/668	122/7206	0.0406600564494
ko00562	Inositol phosphate metabolism	14/668	89/7206	0.0421665521771
ko04068	FoxO signaling pathway	8/668	167/7206	0.042264861277
ko04142	Lysosome	7/668	151/7206	0.0464551088876
ko00512	Mucin type O-glycan biosynthesis	6/668	29/7206	0.0465603116406