ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 146/762 423/7206 3.91128957165e-43 ko04724 Glutamatergic synapse 80/762 152/7206 4.18643067353e-39 ko05033 Nicotine addiction 44/762 56/7206 6.07987191457e-33 ko05032 Morphine addiction 55/762 110/7206 1.26906886043e-25 ko04727 GABAergic synapse 54/762 110/7206 1.12998544001e-24 ko04713 Circadian entrainment 60/762 136/7206 3.35811765648e-24 ko04728 Dopaminergic synapse 70/762 185/7206 2.76074669058e-23 ko04723 Retrograde endocannabinoid signaling 66/762 175/7206 6.57707833732e-22 ko04024 cAMP signaling pathway 82/762 279/7206 5.56484872976e-19 ko04911 Insulin secretion 46/762 117/7206 2.0870651085e-16 ko04725 Cholinergic synapse 55/762 160/7206 2.56835447423e-16 ko05031 Amphetamine addiction 38/762 91/7206 8.91578520681e-15 ko04726 Serotonergic synapse 48/762 137/7206 9.42933370704e-15 ko04020 Calcium signaling pathway 71/762 265/7206 3.05898025442e-14 ko04921 Oxytocin signaling pathway 61/762 209/7206 3.39257611172e-14 ko04261 Adrenergic signaling in cardiomyocytes 59/762 205/7206 1.80108064962e-13 ko04720 Long-term potentiation 38/762 99/7206 2.25720250242e-13 ko04721 Synaptic vesicle cycle 32/762 80/7206 4.93610866449e-12 ko04970 Salivary secretion 34/762 95/7206 4.16424988565e-11 ko04010 MAPK signaling pathway 74/762 321/7206 4.20617506429e-11 ko05030 Cocaine addiction 29/762 73/7206 6.11821667324e-11 ko04742 Taste transduction 26/762 61/7206 9.32900586498e-11 ko04925 Aldosterone synthesis and secretion 32/762 105/7206 1.54017116672e-08 ko04972 Pancreatic secretion 32/762 111/7206 6.72577388594e-08 ko05203 Viral carcinogenesis 6/762 277/7206 7.66994429334e-08 ko04730 Long-term depression 25/762 78/7206 1.97813666545e-07 ko04022 cGMP-PKG signaling pathway 49/762 216/7206 2.04747417001e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 24/762 74/7206 2.70714371349e-07 ko04971 Gastric acid secretion 28/762 98/7206 5.47330068317e-07 ko04072 Phospholipase D signaling pathway 43/762 197/7206 2.8208079269e-06 ko03040 Spliceosome 1/762 145/7206 3.27361901086e-06 ko04260 Cardiac muscle contraction 26/762 98/7206 6.32645619483e-06 ko04514 Cell adhesion molecules (CAMs) 31/762 130/7206 9.75684756655e-06 ko04060 Cytokine-cytokine receptor interaction 4/762 191/7206 1.17470541878e-05 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 22/762 79/7206 1.40878775487e-05 ko04924 Renin secretion 23/762 86/7206 1.86724589066e-05 ko05168 Herpes simplex infection 4/762 182/7206 2.38099540436e-05 ko04070 Phosphatidylinositol signaling system 27/762 112/7206 3.16602348324e-05 ko04915 Estrogen signaling pathway 30/762 131/7206 3.63937523865e-05 ko04360 Axon guidance 45/762 233/7206 4.97097908073e-05 ko04540 Gap junction 29/762 128/7206 5.88812774592e-05 ko05414 Dilated cardiomyopathy 26/762 112/7206 0.000126727746411 ko04110 Cell cycle 3/762 145/7206 0.00017074152442 ko05169 Epstein-Barr virus infection 7/762 206/7206 0.000198477272438 ko04961 Endocrine and other factor-regulated calcium reabsorption 16/762 59/7206 0.000289175571971 ko05322 Systemic lupus erythematosus 4/762 151/7206 0.000415013884099 ko04964 Proximal tubule bicarbonate reclamation 10/762 29/7206 0.00050583348628 ko04932 Non-alcoholic fatty liver disease (NAFLD) 6/762 182/7206 0.000523195355199 ko04014 Ras signaling pathway 47/762 279/7206 0.00100122788584 ko04930 Type II diabetes mellitus 14/762 54/7206 0.00111252426409 ko05164 Influenza A 6/762 167/7206 0.00132535329815 ko05162 Measles 3/762 120/7206 0.0014442017623 ko04740 Olfactory transduction 18/762 80/7206 0.00154258822241 ko04976 Bile secretion 18/762 80/7206 0.00154258822241 ko04350 TGF-beta signaling pathway 2/762 103/7206 0.00174832788507 ko04015 Rap1 signaling pathway 46/762 278/7206 0.0019049417777 ko04918 Thyroid hormone synthesis 19/762 86/7206 0.00204521807779 ko04630 Jak-STAT signaling pathway 4/762 132/7206 0.0023397586773 ko04960 Aldosterone-regulated sodium reabsorption 11/762 41/7206 0.00276967899714 ko04141 Protein processing in endoplasmic reticulum 8/762 184/7206 0.00331580540448 ko04973 Carbohydrate digestion and absorption 11/762 42/7206 0.00340197800294 ko04612 Antigen processing and presentation 1/762 77/7206 0.00414505655096 ko00240 Pyrimidine metabolism 3/762 110/7206 0.00425216624529 ko05205 Proteoglycans in cancer 15/762 271/7206 0.00457190944428 ko05410 Hypertrophic cardiomyopathy (HCM) 20/762 100/7206 0.00463159357928 ko04745 Phototransduction - fly 10/762 38/7206 0.00495908359279 ko04750 Inflammatory mediator regulation of TRP channels 23/762 122/7206 0.00666358708578 ko04621 NOD-like receptor signaling pathway 7/762 157/7206 0.00832483102209 ko05034 Alcoholism 38/762 238/7206 0.00961998203818 ko05231 Choline metabolism in cancer 24/762 134/7206 0.00980587262273 ko03013 RNA transport 8/762 166/7206 0.0105290204931 ko03018 RNA degradation 2/762 84/7206 0.0109113864876 ko04912 GnRH signaling pathway 22/762 122/7206 0.010956440763 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/762 14/7206 0.0115728792111 ko04640 Hematopoietic cell lineage 1/762 64/7206 0.0125980364137 ko04217 Necroptosis 9/762 178/7206 0.0129969730168 ko04550 Signaling pathways regulating pluripotency of stem cells 8/762 165/7206 0.0141465698231 ko04142 Lysosome 7/762 151/7206 0.0151331032434 ko00310 Lysine degradation 2/762 73/7206 0.0213336759784 ko04146 Peroxisome 3/762 89/7206 0.0227355575282 ko04666 Fc gamma R-mediated phagocytosis 21/762 122/7206 0.0244621576596 ko05321 Inflammatory bowel disease (IBD) 1/762 56/7206 0.0268881651993 ko04071 Sphingolipid signaling pathway 26/762 162/7206 0.0275015796253 ko03320 PPAR signaling pathway 2/762 69/7206 0.030308698389 ko04270 Vascular smooth muscle contraction 25/762 154/7206 0.032621275728 ko00562 Inositol phosphate metabolism 16/762 89/7206 0.0348119984904 ko05010 Alzheimer's disease 31/762 202/7206 0.035610572848 ko04923 Regulation of lipolysis in adipocytes 14/762 77/7206 0.0385497791122 ko04064 NF-kappa B signaling pathway 4/762 96/7206 0.0428461306749 ko04371 Apelin signaling pathway 27/762 177/7206 0.0470636019188 ko04744 Phototransduction 8/762 36/7206 0.0489784265048 ko04966 Collecting duct acid secretion 6/762 26/7206 0.0499702852784