ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 39/608 191/7206 1.69803405112e-07 ko04020 Calcium signaling pathway 45/608 265/7206 4.38568129513e-06 ko04710 Circadian rhythm 13/608 43/7206 3.28569951681e-05 ko04070 Phosphatidylinositol signaling system 23/608 112/7206 4.64049027497e-05 ko03010 Ribosome 1/608 129/7206 0.00030110946917 ko04380 Osteoclast differentiation 24/608 134/7206 0.000390996943123 ko03040 Spliceosome 2/608 145/7206 0.000430763282204 ko04110 Cell cycle 2/608 145/7206 0.000430763282204 ko03013 RNA transport 3/608 166/7206 0.00056263730851 ko04610 Complement and coagulation cascades 16/608 79/7206 0.000763796823352 ko04921 Oxytocin signaling pathway 32/608 209/7206 0.000873768158503 ko04933 AGE-RAGE signaling pathway in diabetic complications 23/608 135/7206 0.00139419871657 ko05321 Inflammatory bowel disease (IBD) 12/608 56/7206 0.00205605333052 ko05167 Kaposi's sarcoma-associated herpesvirus infection 29/608 191/7206 0.00207688959866 ko04014 Ras signaling pathway 38/608 279/7206 0.00282365617152 ko04745 Phototransduction - fly 9/608 38/7206 0.00359050263473 ko04022 cGMP-PKG signaling pathway 31/608 216/7206 0.00383806658664 ko04919 Thyroid hormone signaling pathway 22/608 143/7206 0.00550309499614 ko04922 Glucagon signaling pathway 20/608 128/7206 0.00595070160001 ko04960 Aldosterone-regulated sodium reabsorption 9/608 41/7206 0.00614775317624 ko05214 Glioma 14/608 79/7206 0.00669913233291 ko05322 Systemic lupus erythematosus 4/608 151/7206 0.00693704504099 ko04713 Circadian entrainment 21/608 136/7206 0.00708772076492 ko04925 Aldosterone synthesis and secretion 17/608 105/7206 0.007438397145 ko04650 Natural killer cell mediated cytotoxicity 16/608 97/7206 0.00861574158089 ko04137 Mitophagy - animal 14/608 82/7206 0.00879226130123 ko04510 Focal adhesion 32/608 240/7206 0.00888462016317 ko05146 Amoebiasis 16/608 99/7206 0.00982404036738 ko04672 Intestinal immune network for IgA production 8/608 37/7206 0.0105339886408 ko05203 Viral carcinogenesis 12/608 277/7206 0.0107175928507 ko05031 Amphetamine addiction 15/608 91/7206 0.0116206141101 ko04270 Vascular smooth muscle contraction 22/608 154/7206 0.0123285659543 ko04072 Phospholipase D signaling pathway 27/608 197/7206 0.0126240232925 ko00330 Arginine and proline metabolism 11/608 61/7206 0.0165520908491 ko00592 alpha-Linolenic acid metabolism 5/608 19/7206 0.0180544558889 ko00350 Tyrosine metabolism 7/608 33/7206 0.0181145851459 ko04668 TNF signaling pathway 18/608 120/7206 0.0184901338155 ko04662 B cell receptor signaling pathway 14/608 88/7206 0.0186055952902 ko04621 NOD-like receptor signaling pathway 22/608 157/7206 0.0187913646032 ko04711 Circadian rhythm - fly 4/608 13/7206 0.0193696539539 ko04066 HIF-1 signaling pathway 18/608 123/7206 0.0203253750337 ko04725 Cholinergic synapse 22/608 160/7206 0.020482855078 ko04730 Long-term depression 13/608 78/7206 0.0210261906365 ko04512 ECM-receptor interaction 13/608 79/7206 0.021792890785 ko00565 Ether lipid metabolism 8/608 42/7206 0.0222171241978 ko00120 Primary bile acid biosynthesis 5/608 20/7206 0.0224456784071 ko05230 Central carbon metabolism in cancer 13/608 81/7206 0.0237982033625 ko05223 Non-small cell lung cancer 11/608 66/7206 0.0240107206286 ko04971 Gastric acid secretion 15/608 98/7206 0.0253194670517 ko05160 Hepatitis C 21/608 153/7206 0.0259279669855 ko04720 Long-term potentiation 15/608 99/7206 0.0262390143554 ko04062 Chemokine signaling pathway 26/608 201/7206 0.027593073222 ko05152 Tuberculosis 24/608 187/7206 0.0329574468258 ko04068 FoxO signaling pathway 22/608 167/7206 0.0335224875424 ko00643 Styrene degradation 2/608 4/7206 0.0380167219367 ko04724 Glutamatergic synapse 20/608 152/7206 0.0391124150355 ko04658 Th1 and Th2 cell differentiation 14/608 96/7206 0.0396667218797 ko04064 NF-kappa B signaling pathway 14/608 96/7206 0.0396667218797 ko05231 Choline metabolism in cancer 18/608 134/7206 0.0413168206079 ko04740 Olfactory transduction 12/608 80/7206 0.0419703229798 ko04120 Ubiquitin mediated proteolysis 5/608 138/7206 0.0425331237317 ko03320 PPAR signaling pathway 11/608 69/7206 0.0449957273229 ko00564 Glycerophospholipid metabolism 14/608 99/7206 0.0455133111619 ko04151 PI3K-Akt signaling pathway 44/608 390/7206 0.0483967576791 ko04659 Th17 cell differentiation 15/608 106/7206 0.0495485706098