ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	215/1320	423/7206	1.24310654425e-55
ko04724	Glutamatergic synapse	93/1320	152/7206	2.31869110813e-32
ko05033	Nicotine addiction	50/1320	56/7206	6.65420413294e-31
ko05032	Morphine addiction	73/1320	110/7206	6.79871153905e-29
ko04713	Circadian entrainment	80/1320	136/7206	2.60886621544e-26
ko04727	GABAergic synapse	70/1320	110/7206	4.4616034845e-26
ko04728	Dopaminergic synapse	89/1320	185/7206	7.08743137358e-21
ko04721	Synaptic vesicle cycle	52/1320	80/7206	2.79715497997e-20
ko04725	Cholinergic synapse	79/1320	160/7206	1.62620635451e-19
ko04020	Calcium signaling pathway	109/1320	265/7206	1.05095991166e-18
ko04024	cAMP signaling pathway	111/1320	279/7206	1.01631466505e-17
ko04723	Retrograde endocannabinoid signaling	80/1320	175/7206	3.32332637178e-17
ko04911	Insulin secretion	59/1320	117/7206	2.07526798835e-15
ko04742	Taste transduction	39/1320	61/7206	3.68636306505e-15
ko04921	Oxytocin signaling pathway	85/1320	209/7206	2.16012264296e-14
ko04726	Serotonergic synapse	63/1320	137/7206	5.99219805098e-14
ko04744	Phototransduction	27/1320	36/7206	1.70326797891e-13
ko03040	Spliceosome	1/1320	145/7206	9.60257656232e-12
ko04261	Adrenergic signaling in cardiomyocytes	78/1320	205/7206	2.09940278413e-11
ko04360	Axon guidance	85/1320	233/7206	2.28328755143e-11
ko04720	Long-term potentiation	47/1320	99/7206	2.4420578346e-11
ko05031	Amphetamine addiction	44/1320	91/7206	4.94770562822e-11
ko04970	Salivary secretion	44/1320	95/7206	2.93082977816e-10
ko04740	Olfactory transduction	38/1320	80/7206	1.97831094511e-09
ko05203	Viral carcinogenesis	19/1320	277/7206	4.75044144093e-08
ko03013	RNA transport	7/1320	166/7206	7.16193957601e-08
ko04022	cGMP-PKG signaling pathway	72/1320	216/7206	8.40780288771e-08
ko04060	Cytokine-cytokine receptor interaction	10/1320	191/7206	1.1726809039e-07
ko05030	Cocaine addiction	32/1320	73/7206	3.84252073854e-07
ko05168	Herpes simplex infection	10/1320	182/7206	4.94979968001e-07
ko04971	Gastric acid secretion	39/1320	98/7206	5.1874490539e-07
ko04925	Aldosterone synthesis and secretion	41/1320	105/7206	5.93081463945e-07
ko05322	Systemic lupus erythematosus	7/1320	151/7206	1.03965752031e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1320	74/7206	2.21760855346e-06
ko05164	Influenza A	10/1320	167/7206	6.03085731676e-06
ko04010	MAPK signaling pathway	91/1320	321/7206	8.05886160619e-06
ko04070	Phosphatidylinositol signaling system	40/1320	112/7206	1.06622842162e-05
ko04540	Gap junction	44/1320	128/7206	1.35768778365e-05
ko04141	Protein processing in endoplasmic reticulum	13/1320	184/7206	1.7042494441e-05
ko04610	Complement and coagulation cascades	2/1320	79/7206	2.82892799737e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1320	79/7206	2.82892799737e-05
ko04745	Phototransduction - fly	18/1320	38/7206	3.89221326073e-05
ko04966	Collecting duct acid secretion	14/1320	26/7206	4.76223628192e-05
ko04972	Pancreatic secretion	38/1320	111/7206	5.5733421412e-05
ko04621	NOD-like receptor signaling pathway	11/1320	157/7206	6.23543850784e-05
ko04014	Ras signaling pathway	77/1320	279/7206	0.000100159149244
ko04924	Renin secretion	31/1320	86/7206	0.000103978490579
ko04072	Phospholipase D signaling pathway	58/1320	197/7206	0.000112943401987
ko05169	Epstein-Barr virus infection	18/1320	206/7206	0.000156937822567
ko04371	Apelin signaling pathway	53/1320	177/7206	0.000157951870352
ko04730	Long-term depression	28/1320	78/7206	0.000188247345327
ko05110	Vibrio cholerae infection	24/1320	63/7206	0.000210202079213
ko04514	Cell adhesion molecules (CAMs)	41/1320	130/7206	0.000219733987463
ko04064	NF-kappa B signaling pathway	5/1320	96/7206	0.00027202359055
ko05205	Proteoglycans in cancer	28/1320	271/7206	0.000296513312947
ko05162	Measles	8/1320	120/7206	0.000319843546181
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1320	79/7206	0.000327655934093
ko05140	Leishmaniasis	3/1320	75/7206	0.000428206770216
ko00240	Pyrimidine metabolism	7/1320	110/7206	0.000437639423297
ko05414	Dilated cardiomyopathy	36/1320	112/7206	0.000466537571346
ko04750	Inflammatory mediator regulation of TRP channels	38/1320	122/7206	0.000537889538134
ko04260	Cardiac muscle contraction	32/1320	98/7206	0.000547053179114
ko04120	Ubiquitin mediated proteolysis	11/1320	138/7206	0.000782439828515
ko04146	Peroxisome	5/1320	89/7206	0.00079705622728
ko04110	Cell cycle	12/1320	145/7206	0.00102015082035
ko04976	Bile secretion	27/1320	80/7206	0.00112159290691
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1320	14/7206	0.0013045682104
ko04612	Antigen processing and presentation	4/1320	77/7206	0.0015502590358
ko03420	Nucleotide excision repair	1/1320	46/7206	0.00174277755817
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1320	59/7206	0.00183084569165
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1320	182/7206	0.00184444832975
ko00310	Lysine degradation	4/1320	73/7206	0.00215148396124
ko04626	Plant-pathogen interaction	9/1320	18/7206	0.00223497305233
ko00480	Glutathione metabolism	2/1320	55/7206	0.00240140810948
ko04923	Regulation of lipolysis in adipocytes	25/1320	77/7206	0.00266376970856
ko03022	Basal transcription factors	1/1320	44/7206	0.00266672964253
ko04915	Estrogen signaling pathway	38/1320	131/7206	0.00278348269366
ko05144	Malaria	1/1320	45/7206	0.00283734410143
ko00071	Fatty acid degradation	1/1320	45/7206	0.00283734410143
ko05133	Pertussis	6/1320	87/7206	0.00324019502211
ko00590	Arachidonic acid metabolism	2/1320	52/7206	0.00349907152541
ko00330	Arginine and proline metabolism	3/1320	61/7206	0.0041071448047
ko04622	RIG-I-like receptor signaling pathway	3/1320	62/7206	0.00428771083102
ko05161	Hepatitis B	18/1320	173/7206	0.00515790165229
ko04115	p53 signaling pathway	5/1320	74/7206	0.00633535770882
ko03018	RNA degradation	6/1320	84/7206	0.00637877758766
ko05145	Toxoplasmosis	12/1320	126/7206	0.00745075314157
ko04658	Th1 and Th2 cell differentiation	8/1320	96/7206	0.00777334389133
ko05321	Inflammatory bowel disease (IBD)	3/1320	56/7206	0.00849066740885
ko04630	Jak-STAT signaling pathway	13/1320	132/7206	0.00882700059283
ko04640	Hematopoietic cell lineage	4/1320	64/7206	0.008827908301
ko04214	Apoptosis - fly	5/1320	72/7206	0.00883157283331
ko05131	Shigellosis	6/1320	82/7206	0.00891884373138
ko00630	Glyoxylate and dicarboxylate metabolism	1/1320	38/7206	0.00964698099539
ko04657	IL-17 signaling pathway	7/1320	87/7206	0.011326230025
ko04620	Toll-like receptor signaling pathway	9/1320	100/7206	0.0129634193615
ko04964	Proximal tubule bicarbonate reclamation	11/1320	29/7206	0.0130141847189
ko00860	Porphyrin and chlorophyll metabolism	1/1320	34/7206	0.013759281969
ko00500	Starch and sucrose metabolism	1/1320	35/7206	0.0139796232777
ko05016	Huntington's disease	26/1320	215/7206	0.015454059907
ko04918	Thyroid hormone synthesis	25/1320	86/7206	0.0160566877933
ko01524	Platinum drug resistance	6/1320	76/7206	0.0162650904813
ko04912	GnRH signaling pathway	33/1320	122/7206	0.0175163414743
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	10/1320	26/7206	0.0178140401624
ko04711	Circadian rhythm - fly	6/1320	13/7206	0.0198294430269
ko04916	Melanogenesis	37/1320	142/7206	0.0208951896904
ko04015	Rap1 signaling pathway	66/1320	278/7206	0.0215361906878
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1320	40/7206	0.023797837566
ko00260	Glycine, serine and threonine metabolism	3/1320	48/7206	0.0248164171588
ko04142	Lysosome	17/1320	151/7206	0.0249248661182
ko00562	Inositol phosphate metabolism	25/1320	89/7206	0.0261092592959
ko04710	Circadian rhythm	14/1320	43/7206	0.0268547553482
ko04270	Vascular smooth muscle contraction	39/1320	154/7206	0.0268681572492
ko00280	Valine, leucine and isoleucine degradation	4/1320	54/7206	0.0340959407304
ko03410	Base excision repair	2/1320	38/7206	0.0345576632074
ko00620	Pyruvate metabolism	3/1320	46/7206	0.0351000472625
ko05132	Salmonella infection	10/1320	98/7206	0.0351793111489
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1320	100/7206	0.0360235000516
ko05418	Fluid shear stress and atherosclerosis	21/1320	173/7206	0.0361056484078
ko04922	Glucagon signaling pathway	33/1320	128/7206	0.0370338717825
ko04217	Necroptosis	22/1320	178/7206	0.0389478200696
ko03320	PPAR signaling pathway	6/1320	69/7206	0.0407235330988
ko05231	Choline metabolism in cancer	34/1320	134/7206	0.0416342490404
ko01212	Fatty acid metabolism	5/1320	60/7206	0.043998770978
ko05215	Prostate cancer	12/1320	111/7206	0.0466987532893
ko05320	Autoimmune thyroid disease	1/1320	29/7206	0.0493781145413
ko04930	Type II diabetes mellitus	16/1320	54/7206	0.049437922941