ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 29/208 134/7206 4.85011865999e-18 ko04060 Cytokine-cytokine receptor interaction 30/208 191/7206 1.35523774142e-14 ko05164 Influenza A 24/208 167/7206 5.1073433816e-11 ko05161 Hepatitis B 24/208 173/7206 1.09103376452e-10 ko04668 TNF signaling pathway 20/208 120/7206 1.50919124588e-10 ko05167 Kaposi's sarcoma-associated herpesvirus infection 25/208 191/7206 1.56387791828e-10 ko05140 Leishmaniasis 16/208 75/7206 2.4841154553e-10 ko04621 NOD-like receptor signaling pathway 22/208 157/7206 5.65747506944e-10 ko04933 AGE-RAGE signaling pathway in diabetic complications 20/208 135/7206 1.32278312559e-09 ko04620 Toll-like receptor signaling pathway 17/208 100/7206 2.80390925075e-09 ko04630 Jak-STAT signaling pathway 19/208 132/7206 5.73017386943e-09 ko05145 Toxoplasmosis 18/208 126/7206 1.66271795098e-08 ko05160 Hepatitis C 19/208 153/7206 6.74070311606e-08 ko04064 NF-kappa B signaling pathway 15/208 96/7206 8.06880836338e-08 ko05323 Rheumatoid arthritis 14/208 89/7206 2.0341606829e-07 ko05168 Herpes simplex infection 20/208 182/7206 2.33954042458e-07 ko05162 Measles 16/208 120/7206 2.86100827845e-07 ko05321 Inflammatory bowel disease (IBD) 11/208 56/7206 4.24017709985e-07 ko04217 Necroptosis 18/208 178/7206 3.25766380124e-06 ko05144 Malaria 9/208 45/7206 4.20543873611e-06 ko04657 IL-17 signaling pathway 12/208 87/7206 6.43367951142e-06 ko05133 Pertussis 12/208 87/7206 6.43367951142e-06 ko05166 HTLV-I infection 23/208 292/7206 1.02100574881e-05 ko04623 Cytosolic DNA-sensing pathway 8/208 41/7206 1.77205771279e-05 ko05142 Chagas disease (American trypanosomiasis) 14/208 130/7206 2.0494423636e-05 ko05132 Salmonella infection 12/208 98/7206 2.22910370356e-05 ko05152 Tuberculosis 17/208 187/7206 2.54208687244e-05 ko04659 Th17 cell differentiation 12/208 106/7206 4.93074155008e-05 ko04660 T cell receptor signaling pathway 13/208 124/7206 5.40830963534e-05 ko04622 RIG-I-like receptor signaling pathway 9/208 62/7206 6.29163429033e-05 ko04062 Chemokine signaling pathway 17/208 201/7206 6.40171509654e-05 ko04672 Intestinal immune network for IgA production 7/208 37/7206 7.43564031213e-05 ko04931 Insulin resistance 13/208 137/7206 0.000151464240926 ko04662 B cell receptor signaling pathway 10/208 88/7206 0.000204695381521 ko04210 Apoptosis 15/208 180/7206 0.000205131929162 ko05169 Epstein-Barr virus infection 16/208 206/7206 0.0002838724111 ko05418 Fluid shear stress and atherosclerosis 14/208 173/7206 0.00045135804745 ko04650 Natural killer cell mediated cytotoxicity 10/208 97/7206 0.000455167069532 ko04666 Fc gamma R-mediated phagocytosis 11/208 122/7206 0.000754873022239 ko04917 Prolactin signaling pathway 9/208 87/7206 0.000853290484501 ko04920 Adipocytokine signaling pathway 9/208 89/7206 0.00100618834677 ko05134 Legionellosis 8/208 74/7206 0.00123627535095 ko05120 Epithelial cell signaling in Helicobacter pylori infection 9/208 92/7206 0.00127653930033 ko04658 Th1 and Th2 cell differentiation 9/208 96/7206 0.00172521073726 ko04610 Complement and coagulation cascades 8/208 79/7206 0.00189247580598 ko04932 Non-alcoholic fatty liver disease (NAFLD) 13/208 182/7206 0.00225709428054 ko05212 Pancreatic cancer 8/208 83/7206 0.00259360895727 ko05203 Viral carcinogenesis 17/208 277/7206 0.00286514844419 ko04068 FoxO signaling pathway 12/208 167/7206 0.00314691208547 ko04670 Leukocyte transendothelial migration 11/208 151/7206 0.00417324243156 ko04930 Type II diabetes mellitus 6/208 54/7206 0.00437946279595 ko05200 Pathways in cancer 25/208 492/7206 0.00490888167458 ko04010 MAPK signaling pathway 18/208 321/7206 0.00588379186396 ko04664 Fc epsilon RI signaling pathway 7/208 77/7206 0.00656383202212 ko05146 Amoebiasis 8/208 99/7206 0.00761098965972 ko04066 HIF-1 signaling pathway 9/208 123/7206 0.00898918885876 ko05220 Chronic myeloid leukemia 7/208 85/7206 0.0111113324587 ko05210 Colorectal cancer 7/208 86/7206 0.0118086528097 ko05143 African trypanosomiasis 4/208 32/7206 0.0128751061914 ko04624 Toll and Imd signaling pathway 5/208 49/7206 0.0129906185296 ko04915 Estrogen signaling pathway 9/208 131/7206 0.013267568256 ko05215 Prostate cancer 8/208 111/7206 0.0146570976508 ko05150 Staphylococcus aureus infection 4/208 36/7206 0.0192916334947 ko04722 Neurotrophin signaling pathway 10/208 160/7206 0.0259151923024 ko01522 Endocrine resistance 8/208 124/7206 0.0266753205846 ko04611 Platelet activation 10/208 163/7206 0.0272979244238 ko05131 Shigellosis 6/208 82/7206 0.0306543542007 ko04137 Mitophagy - animal 6/208 82/7206 0.0306543542007 ko05330 Allograft rejection 3/208 24/7206 0.0307043086881 ko00051 Fructose and mannose metabolism 4/208 42/7206 0.0320923920094 ko04218 Cellular senescence 10/208 177/7206 0.0371530309413 ko04024 cAMP signaling pathway 14/208 279/7206 0.0419287221823 ko04215 Apoptosis - multiple species 4/208 47/7206 0.0458060886225 ko05031 Amphetamine addiction 6/208 91/7206 0.0472991551029 ko05219 Bladder cancer 4/208 48/7206 0.0488850391403