ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 80/511 145/7206 6.32175525699e-55 ko03008 Ribosome biogenesis in eukaryotes 37/511 79/7206 2.43399399419e-22 ko03020 RNA polymerase 17/511 29/7206 5.23987377962e-13 ko03013 RNA transport 41/511 166/7206 5.6857592462e-13 ko03030 DNA replication 18/511 38/7206 1.36040047215e-11 ko00240 Pyrimidine metabolism 30/511 110/7206 5.73303876659e-11 ko03015 mRNA surveillance pathway 27/511 93/7206 1.11826622024e-10 ko03022 Basal transcription factors 18/511 44/7206 2.78931596586e-10 ko04110 Cell cycle 33/511 145/7206 1.13323518197e-09 ko03420 Nucleotide excision repair 17/511 46/7206 5.65944877068e-09 ko03410 Base excision repair 15/511 38/7206 1.58527801902e-08 ko03018 RNA degradation 21/511 84/7206 2.35484062999e-07 ko04144 Endocytosis 4/511 342/7206 3.79175606802e-07 ko03430 Mismatch repair 9/511 22/7206 9.11886968094e-06 ko04060 Cytokine-cytokine receptor interaction 1/511 191/7206 2.04655284954e-05 ko05169 Epstein-Barr virus infection 32/511 206/7206 2.18639522482e-05 ko00230 Purine metabolism 30/511 194/7206 4.48728112477e-05 ko04111 Cell cycle - yeast 18/511 90/7206 4.74362249755e-05 ko04723 Retrograde endocannabinoid signaling 1/511 175/7206 6.74235641808e-05 ko04024 cAMP signaling pathway 5/511 279/7206 7.20669944103e-05 ko04120 Ubiquitin mediated proteolysis 23/511 138/7206 0.000127917700817 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/511 182/7206 0.000331709106669 ko04062 Chemokine signaling pathway 3/511 201/7206 0.000414362471981 ko04623 Cytosolic DNA-sensing pathway 10/511 41/7206 0.00044423984761 ko04072 Phospholipase D signaling pathway 3/511 197/7206 0.000596687832501 ko04022 cGMP-PKG signaling pathway 4/511 216/7206 0.000692839191811 ko04113 Meiosis - yeast 13/511 70/7206 0.00110269961287 ko04014 Ras signaling pathway 7/511 279/7206 0.0011585822282 ko04921 Oxytocin signaling pathway 4/511 209/7206 0.00140166966162 ko04540 Gap junction 1/511 128/7206 0.00144482460913 ko04725 Cholinergic synapse 2/511 160/7206 0.00146081366468 ko05142 Chagas disease (American trypanosomiasis) 1/511 130/7206 0.00148159810742 ko04514 Cell adhesion molecules (CAMs) 1/511 130/7206 0.00148159810742 ko05160 Hepatitis C 2/511 153/7206 0.00204216547665 ko04912 GnRH signaling pathway 1/511 122/7206 0.00211280543686 ko03460 Fanconi anemia pathway 10/511 51/7206 0.00266789613947 ko04612 Antigen processing and presentation 13/511 77/7206 0.00270685903001 ko03060 Protein export 6/511 23/7206 0.00440253145666 ko05032 Morphine addiction 1/511 110/7206 0.00451123320447 ko04261 Adrenergic signaling in cardiomyocytes 5/511 205/7206 0.00529631202643 ko04530 Tight junction 6/511 228/7206 0.00537399338538 ko04270 Vascular smooth muscle contraction 3/511 154/7206 0.00661967547067 ko04371 Apelin signaling pathway 4/511 177/7206 0.00706593182454 ko04010 MAPK signaling pathway 11/511 321/7206 0.00716533561619 ko03440 Homologous recombination 8/511 41/7206 0.00719434894718 ko05168 Herpes simplex infection 23/511 182/7206 0.00754453550771 ko04015 Rap1 signaling pathway 9/511 278/7206 0.00827929805628 ko05145 Toxoplasmosis 2/511 126/7206 0.00828023436315 ko03010 Ribosome 2/511 129/7206 0.00838232437293 ko00564 Glycerophospholipid metabolism 1/511 99/7206 0.00958642681385 ko05146 Amoebiasis 1/511 99/7206 0.00958642681385 ko04620 Toll-like receptor signaling pathway 1/511 100/7206 0.00962741239145 ko04750 Inflammatory mediator regulation of TRP channels 2/511 122/7206 0.0117877658722 ko04728 Dopaminergic synapse 5/511 185/7206 0.0132552330984 ko05166 HTLV-I infection 32/511 292/7206 0.0137978316804 ko04810 Regulation of actin cytoskeleton 9/511 264/7206 0.0141360800369 ko04911 Insulin secretion 2/511 117/7206 0.0167897540859 ko04713 Circadian entrainment 3/511 136/7206 0.0179152892279 ko04071 Sphingolipid signaling pathway 4/511 162/7206 0.0187074475288 ko04510 Focal adhesion 8/511 240/7206 0.0203043213132 ko04146 Peroxisome 1/511 89/7206 0.0203768744176 ko05120 Epithelial cell signaling in Helicobacter pylori infection 1/511 92/7206 0.0214023284939 ko04972 Pancreatic secretion 2/511 111/7206 0.0236747182956 ko04915 Estrogen signaling pathway 3/511 131/7206 0.0247913352858 ko04380 Osteoclast differentiation 3/511 134/7206 0.0252766873968 ko04933 AGE-RAGE signaling pathway in diabetic complications 3/511 135/7206 0.0256074625701 ko04621 NOD-like receptor signaling pathway 4/511 157/7206 0.0257967518522 ko04360 Axon guidance 8/511 233/7206 0.0263477170437 ko05230 Central carbon metabolism in cancer 1/511 81/7206 0.029325498654 ko04068 FoxO signaling pathway 5/511 167/7206 0.0322913164006 ko04151 PI3K-Akt signaling pathway 17/511 390/7206 0.0324248308388 ko04659 Th17 cell differentiation 2/511 106/7206 0.033574702733 ko04370 VEGF signaling pathway 1/511 77/7206 0.0424924053216 ko04664 Fc epsilon RI signaling pathway 1/511 77/7206 0.0424924053216 ko04722 Neurotrophin signaling pathway 5/511 160/7206 0.0431127348268 ko04611 Platelet activation 5/511 163/7206 0.0433281460745 ko04512 ECM-receptor interaction 1/511 79/7206 0.0433801204138 ko04740 Olfactory transduction 1/511 80/7206 0.0441276766402 ko05132 Salmonella infection 2/511 98/7206 0.0464663962295 ko04720 Long-term potentiation 2/511 99/7206 0.0466573062112