ko pathway ratio_in_study ratio_in_pop p_value ko00380 Tryptophan metabolism 13/233 50/7206 3.71163220451e-09 ko04974 Protein digestion and absorption 16/233 96/7206 5.64995746006e-08 ko00643 Styrene degradation 4/233 4/7206 1.06602738159e-06 ko00071 Fatty acid degradation 10/233 45/7206 1.215304065e-06 ko05204 Chemical carcinogenesis 10/233 48/7206 2.28794603752e-06 ko00350 Tyrosine metabolism 8/233 33/7206 7.30658555202e-06 ko00260 Glycine, serine and threonine metabolism 9/233 48/7206 1.84601958279e-05 ko04964 Proximal tubule bicarbonate reclamation 7/233 29/7206 2.86795218351e-05 ko04978 Mineral absorption 8/233 40/7206 3.32745331997e-05 ko00980 Metabolism of xenobiotics by cytochrome P450 8/233 40/7206 3.32745331997e-05 ko00140 Steroid hormone biosynthesis 8/233 41/7206 4.02020611912e-05 ko04976 Bile secretion 11/233 80/7206 4.66528589472e-05 ko00830 Retinol metabolism 8/233 42/7206 4.82935139828e-05 ko00280 Valine, leucine and isoleucine degradation 9/233 54/7206 4.94305997806e-05 ko00620 Pyruvate metabolism 8/233 46/7206 9.54865570372e-05 ko00360 Phenylalanine metabolism 5/233 17/7206 0.000152359126015 ko04610 Complement and coagulation cascades 10/233 79/7206 0.000209268055772 ko00281 Geraniol degradation 3/233 5/7206 0.00031806493285 ko03320 PPAR signaling pathway 9/233 69/7206 0.000345572498074 ko00120 Primary bile acid biosynthesis 5/233 20/7206 0.000352563586977 ko00053 Ascorbate and aldarate metabolism 5/233 22/7206 0.000567984704397 ko00362 Benzoate degradation 3/233 6/7206 0.000620942230943 ko00270 Cysteine and methionine metabolism 7/233 47/7206 0.000703943257922 ko04080 Neuroactive ligand-receptor interaction 3/233 423/7206 0.00090791294893 ko00340 Histidine metabolism 5/233 25/7206 0.00105867729735 ko00982 Drug metabolism - cytochrome P450 6/233 37/7206 0.00107398188378 ko00630 Glyoxylate and dicarboxylate metabolism 6/233 38/7206 0.00124143344027 ko00983 Drug metabolism - other enzymes 6/233 42/7206 0.00211815776609 ko04972 Pancreatic secretion 10/233 111/7206 0.00304024730159 ko05160 Hepatitis C 12/233 153/7206 0.00386917714406 ko00640 Propanoate metabolism 5/233 34/7206 0.0043768513845 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/233 11/7206 0.00454235608248 ko00410 beta-Alanine metabolism 5/233 35/7206 0.00497442227438 ko05133 Pertussis 8/233 87/7206 0.00687053219282 ko05034 Alcoholism 1/233 238/7206 0.00756343462958 ko04920 Adipocytokine signaling pathway 8/233 89/7206 0.00786023755642 ko04146 Peroxisome 8/233 89/7206 0.00786023755642 ko01200 Carbon metabolism 10/233 128/7206 0.00831547102265 ko00040 Pentose and glucuronate interconversions 4/233 26/7206 0.00909679649347 ko00650 Butanoate metabolism 4/233 26/7206 0.00909679649347 ko04670 Leukocyte transendothelial migration 11/233 151/7206 0.00959352958989 ko00010 Glycolysis / Gluconeogenesis 7/233 74/7206 0.00964876482497 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/233 5/7206 0.00975970745896 ko00565 Ether lipid metabolism 5/233 42/7206 0.010859669612 ko01212 Fatty acid metabolism 6/233 60/7206 0.0124938046374 ko01230 Biosynthesis of amino acids 7/233 85/7206 0.0196660725923 ko04530 Tight junction 14/233 228/7206 0.0200395032133 ko00592 alpha-Linolenic acid metabolism 3/233 19/7206 0.0220521398277 ko00910 Nitrogen metabolism 3/233 19/7206 0.0220521398277 ko00680 Methane metabolism 4/233 34/7206 0.0230920410008 ko00100 Steroid biosynthesis 3/233 21/7206 0.0288726714368 ko00310 Lysine degradation 6/233 73/7206 0.0301205512189 ko04310 Wnt signaling pathway 1/233 181/7206 0.0315497467597 ko04141 Protein processing in endoplasmic reticulum 1/233 184/7206 0.0318928474772 ko00627 Aminobenzoate degradation 2/233 9/7206 0.0322592087914 ko00930 Caprolactam degradation 2/233 9/7206 0.0322592087914 ko00401 Novobiocin biosynthesis 1/233 1/7206 0.0323341659729 ko00591 Linoleic acid metabolism 3/233 22/7206 0.0326540601473 ko04977 Vitamin digestion and absorption 3/233 22/7206 0.0326540601473 ko04390 Hippo signaling pathway 1/233 188/7206 0.0327902020218 ko05200 Pathways in cancer 8/233 492/7206 0.034093031352 ko01524 Platinum drug resistance 6/233 76/7206 0.0357480233059 ko00072 Synthesis and degradation of ketone bodies 2/233 10/7206 0.0394780901144 ko04152 AMPK signaling pathway 10/233 161/7206 0.0402931973354 ko04512 ECM-receptor interaction 6/233 79/7206 0.0420115241874 ko05410 Hypertrophic cardiomyopathy (HCM) 7/233 100/7206 0.0426763971008 ko04973 Carbohydrate digestion and absorption 4/233 42/7206 0.0456971358054 ko00330 Arginine and proline metabolism 5/233 61/7206 0.0465347501977 ko04723 Retrograde endocannabinoid signaling 1/233 175/7206 0.0468564690977