ko pathway ratio_in_study ratio_in_pop p_value ko04744 Phototransduction 17/281 36/7206 3.04812785909e-15 ko04724 Glutamatergic synapse 30/281 152/7206 8.38984864748e-14 ko04727 GABAergic synapse 23/281 110/7206 2.20774090425e-11 ko04740 Olfactory transduction 19/281 80/7206 1.25497792893e-10 ko04728 Dopaminergic synapse 27/281 185/7206 2.14120637995e-09 ko05032 Morphine addiction 20/281 110/7206 6.24093126192e-09 ko05033 Nicotine addiction 14/281 56/7206 1.81049384719e-08 ko04080 Neuroactive ligand-receptor interaction 41/281 423/7206 3.94189245848e-08 ko04723 Retrograde endocannabinoid signaling 23/281 175/7206 2.53676719013e-07 ko04725 Cholinergic synapse 21/281 160/7206 8.79796542833e-07 ko04742 Taste transduction 12/281 61/7206 3.07701783202e-06 ko04713 Circadian entrainment 18/281 136/7206 4.81612355681e-06 ko04726 Serotonergic synapse 16/281 137/7206 7.8066919645e-05 ko04024 cAMP signaling pathway 24/281 279/7206 0.00022148990012 ko04721 Synaptic vesicle cycle 11/281 80/7206 0.000248453765014 ko05203 Viral carcinogenesis 1/281 277/7206 0.000354778373821 ko05030 Cocaine addiction 10/281 73/7206 0.000488467896969 ko04964 Proximal tubule bicarbonate reclamation 6/281 29/7206 0.000741598593738 ko05034 Alcoholism 20/281 238/7206 0.00101568989354 ko00830 Retinol metabolism 7/281 42/7206 0.00106158716092 ko04261 Adrenergic signaling in cardiomyocytes 18/281 205/7206 0.0012818949359 ko04514 Cell adhesion molecules (CAMs) 13/281 130/7206 0.00159927512755 ko04911 Insulin secretion 12/281 117/7206 0.00193251760724 ko04976 Bile secretion 9/281 80/7206 0.00375018928491 ko00910 Nitrogen metabolism 4/281 19/7206 0.00551695433773 ko05014 Amyotrophic lateral sclerosis (ALS) 8/281 74/7206 0.00782474832826 ko05031 Amphetamine addiction 9/281 91/7206 0.00874435085928 ko05168 Herpes simplex infection 1/281 182/7206 0.0104482830565 ko04932 Non-alcoholic fatty liver disease (NAFLD) 1/281 182/7206 0.0104482830565 ko04970 Salivary secretion 9/281 95/7206 0.0114592059258 ko04260 Cardiac muscle contraction 9/281 98/7206 0.0138768280717 ko04971 Gastric acid secretion 9/281 98/7206 0.0138768280717 ko04720 Long-term potentiation 9/281 99/7206 0.0147610343726 ko04745 Phototransduction - fly 5/281 38/7206 0.0152173131138 ko05161 Hepatitis B 1/281 173/7206 0.0152211412592 ko04217 Necroptosis 1/281 178/7206 0.0160030781513 ko04978 Mineral absorption 5/281 40/7206 0.0187336627964 ko05166 HTLV-I infection 4/281 292/7206 0.0193153118153 ko04020 Calcium signaling pathway 18/281 265/7206 0.0217316157016 ko03013 RNA transport 1/281 166/7206 0.0225984670139 ko05164 Influenza A 1/281 167/7206 0.0228598452874 ko05169 Epstein-Barr virus infection 2/281 206/7206 0.0258307773723 ko04510 Focal adhesion 3/281 240/7206 0.0262078800157 ko04371 Apelin signaling pathway 13/281 177/7206 0.0273500988768 ko05322 Systemic lupus erythematosus 1/281 151/7206 0.0314350525264 ko04621 NOD-like receptor signaling pathway 1/281 157/7206 0.033003545348 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 7/281 79/7206 0.0337684180809 ko04060 Cytokine-cytokine receptor interaction 2/281 191/7206 0.0352174400434 ko05205 Proteoglycans in cancer 4/281 271/7206 0.0356459521171 ko05206 MicroRNAs in cancer 2/281 177/7206 0.0489005054577 ko05016 Huntington's disease 3/281 215/7206 0.0491492177096 ko04924 Renin secretion 7/281 86/7206 0.0499003597677