ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 41/298 191/7206 5.21458229711e-19 ko05340 Primary immunodeficiency 16/298 30/7206 4.24172000265e-15 ko04650 Natural killer cell mediated cytotoxicity 25/298 97/7206 6.59753535883e-14 ko05164 Influenza A 32/298 167/7206 1.49578279013e-13 ko04380 Osteoclast differentiation 28/298 134/7206 5.78133701118e-13 ko05140 Leishmaniasis 20/298 75/7206 1.16383691242e-11 ko05152 Tuberculosis 31/298 187/7206 1.99697234481e-11 ko05330 Allograft rejection 12/298 24/7206 3.48411936547e-11 ko05145 Toxoplasmosis 25/298 126/7206 3.5658479648e-11 ko04612 Antigen processing and presentation 19/298 77/7206 1.69058244191e-10 ko05168 Herpes simplex infection 29/298 182/7206 2.48412464811e-10 ko05332 Graft-versus-host disease 10/298 18/7206 4.11170247256e-10 ko05321 Inflammatory bowel disease (IBD) 16/298 56/7206 4.57008433858e-10 ko05162 Measles 23/298 120/7206 4.64914339376e-10 ko04621 NOD-like receptor signaling pathway 26/298 157/7206 9.38308788338e-10 ko04659 Th17 cell differentiation 21/298 106/7206 1.44761456171e-09 ko04660 T cell receptor signaling pathway 21/298 124/7206 2.74832731781e-08 ko04640 Hematopoietic cell lineage 15/298 64/7206 3.17702603103e-08 ko04620 Toll-like receptor signaling pathway 18/298 100/7206 1.06164974786e-07 ko05150 Staphylococcus aureus infection 11/298 36/7206 1.19944365562e-07 ko05320 Autoimmune thyroid disease 10/298 29/7206 1.25331015368e-07 ko04658 Th1 and Th2 cell differentiation 17/298 96/7206 3.09243787411e-07 ko04064 NF-kappa B signaling pathway 17/298 96/7206 3.09243787411e-07 ko04940 Type I diabetes mellitus 10/298 32/7206 3.61355184282e-07 ko04630 Jak-STAT signaling pathway 20/298 132/7206 3.94789308551e-07 ko04062 Chemokine signaling pathway 25/298 201/7206 6.7784858992e-07 ko04217 Necroptosis 23/298 178/7206 9.81742326362e-07 ko04672 Intestinal immune network for IgA production 10/298 37/7206 1.62261959666e-06 ko05133 Pertussis 15/298 87/7206 2.21309708268e-06 ko04662 B cell receptor signaling pathway 15/298 88/7206 2.56974824264e-06 ko05310 Asthma 7/298 17/7206 2.62368723402e-06 ko04145 Phagosome 21/298 162/7206 2.79952053138e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 23/298 191/7206 3.38273602426e-06 ko05144 Malaria 10/298 45/7206 1.10698480751e-05 ko04664 Fc epsilon RI signaling pathway 13/298 77/7206 1.34731638979e-05 ko04611 Platelet activation 19/298 163/7206 3.8871005188e-05 ko05161 Hepatitis B 19/298 173/7206 8.83397829546e-05 ko04622 RIG-I-like receptor signaling pathway 10/298 62/7206 0.000199960730544 ko05323 Rheumatoid arthritis 12/298 89/7206 0.000273114166648 ko05142 Chagas disease (American trypanosomiasis) 15/298 130/7206 0.000284814998135 ko03050 Proteasome 9/298 54/7206 0.00032279320608 ko04610 Complement and coagulation cascades 11/298 79/7206 0.000368482093393 ko04666 Fc gamma R-mediated phagocytosis 14/298 122/7206 0.000478609467824 ko05160 Hepatitis C 16/298 153/7206 0.000552847258163 ko05034 Alcoholism 1/298 238/7206 0.00074138733433 ko04514 Cell adhesion molecules (CAMs) 14/298 130/7206 0.000909094623541 ko00590 Arachidonic acid metabolism 8/298 52/7206 0.00119736307214 ko05416 Viral myocarditis 8/298 55/7206 0.00174010171326 ko05131 Shigellosis 10/298 82/7206 0.00191819689691 ko05146 Amoebiasis 11/298 99/7206 0.00246953267343 ko04623 Cytosolic DNA-sensing pathway 6/298 41/7206 0.0063030818711 ko05132 Salmonella infection 10/298 98/7206 0.0070325697892 ko04310 Wnt signaling pathway 1/298 181/7206 0.00717113396249 ko05143 African trypanosomiasis 5/298 32/7206 0.00940073713171 ko05224 Breast cancer 1/298 174/7206 0.0105818151025 ko04670 Leukocyte transendothelial migration 13/298 151/7206 0.0110993224028 ko05016 Huntington's disease 2/298 215/7206 0.0131397966828 ko04152 AMPK signaling pathway 1/298 161/7206 0.0150134735345 ko04360 Axon guidance 3/298 233/7206 0.0189188608149 ko04210 Apoptosis 14/298 180/7206 0.0208673383284 ko05012 Parkinson's disease 1/298 155/7206 0.02217094242 ko05166 HTLV-I infection 20/298 292/7206 0.0236030619672 ko04390 Hippo signaling pathway 2/298 188/7206 0.0249313160467 ko04114 Oocyte meiosis 1/298 139/7206 0.0311794286197 ko04080 Neuroactive ligand-receptor interaction 9/298 423/7206 0.0315082113076 ko04668 TNF signaling pathway 10/298 120/7206 0.0324578116009 ko05206 MicroRNAs in cancer 2/298 177/7206 0.034931019484 ko04144 Endocytosis 22/298 342/7206 0.0359449329557 ko04728 Dopaminergic synapse 2/298 185/7206 0.0363251228888 ko00966 Glucosinolate biosynthesis 1/298 1/7206 0.0413544268664 ko04915 Estrogen signaling pathway 1/298 131/7206 0.0448263579612 ko04910 Insulin signaling pathway 2/298 172/7206 0.0495157986794