ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 115/830 423/7206 5.02569266196e-20 ko04020 Calcium signaling pathway 72/830 265/7206 9.05572069931e-13 ko04724 Glutamatergic synapse 49/830 152/7206 5.10394802522e-12 ko04713 Circadian entrainment 43/830 136/7206 2.14190418193e-10 ko04024 cAMP signaling pathway 66/830 279/7206 4.91438220787e-09 ko05032 Morphine addiction 35/830 110/7206 8.75964028293e-09 ko05033 Nicotine addiction 23/830 56/7206 1.45990651952e-08 ko04921 Oxytocin signaling pathway 53/830 209/7206 1.5014590266e-08 ko04022 cGMP-PKG signaling pathway 54/830 216/7206 2.55622746525e-08 ko04728 Dopaminergic synapse 48/830 185/7206 3.1901564972e-08 ko04911 Insulin secretion 35/830 117/7206 5.13950274063e-08 ko04727 GABAergic synapse 33/830 110/7206 1.14991097748e-07 ko04725 Cholinergic synapse 42/830 160/7206 2.08124832831e-07 ko04970 Salivary secretion 29/830 95/7206 4.48975204214e-07 ko04261 Adrenergic signaling in cardiomyocytes 48/830 205/7206 1.06954077497e-06 ko04720 Long-term potentiation 29/830 99/7206 1.16930338946e-06 ko04721 Synaptic vesicle cycle 25/830 80/7206 1.72339876271e-06 ko05031 Amphetamine addiction 27/830 91/7206 2.07388216225e-06 ko04070 Phosphatidylinositol signaling system 31/830 112/7206 2.93833657589e-06 ko04730 Long-term depression 24/830 78/7206 3.76662103728e-06 ko03010 Ribosome 1/830 129/7206 4.29537886686e-06 ko03040 Spliceosome 2/830 145/7206 5.10938904305e-06 ko04726 Serotonergic synapse 34/830 137/7206 9.81279269125e-06 ko04723 Retrograde endocannabinoid signaling 40/830 175/7206 1.82620569102e-05 ko03013 RNA transport 4/830 166/7206 2.1953636162e-05 ko05322 Systemic lupus erythematosus 3/830 151/7206 2.48407532284e-05 ko04925 Aldosterone synthesis and secretion 27/830 105/7206 4.03493153037e-05 ko04745 Phototransduction - fly 14/830 38/7206 4.38729125911e-05 ko04710 Circadian rhythm 15/830 43/7206 4.94358337337e-05 ko04922 Glucagon signaling pathway 31/830 128/7206 5.8919404514e-05 ko04971 Gastric acid secretion 25/830 98/7206 8.97149766057e-05 ko04742 Taste transduction 18/830 61/7206 0.000112211482574 ko04514 Cell adhesion molecules (CAMs) 30/830 130/7206 0.000144969757751 ko04072 Phospholipase D signaling pathway 41/830 197/7206 0.000151361878855 ko05168 Herpes simplex infection 7/830 182/7206 0.000359887051421 ko04010 MAPK signaling pathway 58/830 321/7206 0.000440502029252 ko05203 Viral carcinogenesis 15/830 277/7206 0.000706837780072 ko04750 Inflammatory mediator regulation of TRP channels 27/830 122/7206 0.000795007715043 ko04110 Cell cycle 5/830 145/7206 0.000871112087973 ko04014 Ras signaling pathway 50/830 279/7206 0.00147395115122 ko04270 Vascular smooth muscle contraction 31/830 154/7206 0.00191444044177 ko04972 Pancreatic secretion 24/830 111/7206 0.00227268005718 ko04626 Plant-pathogen interaction 7/830 18/7206 0.00265358651457 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/830 14/7206 0.00304189230826 ko04540 Gap junction 26/830 128/7206 0.00316953162156 ko04120 Ubiquitin mediated proteolysis 6/830 138/7206 0.00450077731557 ko04360 Axon guidance 41/830 233/7206 0.00473133045201 ko04924 Renin secretion 19/830 86/7206 0.00549207342831 ko00562 Inositol phosphate metabolism 19/830 89/7206 0.00673575192265 ko04141 Protein processing in endoplasmic reticulum 10/830 184/7206 0.00675892683177 ko04966 Collecting duct acid secretion 8/830 26/7206 0.00701205716844 ko04371 Apelin signaling pathway 32/830 177/7206 0.00842031198161 ko05030 Cocaine addiction 16/830 73/7206 0.00913783553691 ko05130 Pathogenic Escherichia coli infection 2/830 77/7206 0.0104890020296 ko04612 Antigen processing and presentation 2/830 77/7206 0.0104890020296 ko04964 Proximal tubule bicarbonate reclamation 8/830 29/7206 0.0141133791183 ko04657 IL-17 signaling pathway 3/830 87/7206 0.0163133197383 ko04923 Regulation of lipolysis in adipocytes 16/830 77/7206 0.017813440236 ko00520 Amino sugar and nucleotide sugar metabolism 1/830 55/7206 0.017821369719 ko05164 Influenza A 10/830 167/7206 0.0196580307737 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 16/830 79/7206 0.0204626899932 ko04960 Aldosterone-regulated sodium reabsorption 10/830 41/7206 0.0221503161566 ko04260 Cardiac muscle contraction 19/830 98/7206 0.0238546662292 ko00010 Glycolysis / Gluconeogenesis 15/830 74/7206 0.0262144322208 ko05014 Amyotrophic lateral sclerosis (ALS) 15/830 74/7206 0.0262144322208 ko04930 Type II diabetes mellitus 12/830 54/7206 0.0284519295453 ko05110 Vibrio cholerae infection 13/830 63/7206 0.0292422064963 ko05161 Hepatitis B 11/830 173/7206 0.0295570112569 ko05224 Breast cancer 11/830 174/7206 0.0296886772003 ko04740 Olfactory transduction 16/830 80/7206 0.0320083573337 ko05230 Central carbon metabolism in cancer 16/830 81/7206 0.0330471522331 ko05169 Epstein-Barr virus infection 14/830 206/7206 0.0344627311701 ko05219 Bladder cancer 1/830 48/7206 0.0383746902563 ko04114 Oocyte meiosis 24/830 139/7206 0.0427351604016 ko04015 Rap1 signaling pathway 43/830 278/7206 0.0435406443786 ko00240 Pyrimidine metabolism 6/830 110/7206 0.0487695407031