ko pathway ratio_in_study ratio_in_pop p_value ko04022 cGMP-PKG signaling pathway 49/710 216/7206 1.66936637437e-08 ko04922 Glucagon signaling pathway 33/710 128/7206 1.43029248394e-07 ko04713 Circadian entrainment 34/710 136/7206 2.06657943617e-07 ko04921 Oxytocin signaling pathway 45/710 209/7206 3.53589413546e-07 ko04724 Glutamatergic synapse 36/710 152/7206 5.04921518729e-07 ko04020 Calcium signaling pathway 52/710 265/7206 8.68928809328e-07 ko04911 Insulin secretion 28/710 117/7206 6.14985980911e-06 ko04710 Circadian rhythm 15/710 43/7206 7.50911449604e-06 ko04970 Salivary secretion 24/710 95/7206 1.05810968983e-05 ko04514 Cell adhesion molecules (CAMs) 29/710 130/7206 1.93404713719e-05 ko04070 Phosphatidylinositol signaling system 26/710 112/7206 3.15920938049e-05 ko03010 Ribosome 1/710 129/7206 3.64203325834e-05 ko04745 Phototransduction - fly 13/710 38/7206 3.87664295685e-05 ko04371 Apelin signaling pathway 35/710 177/7206 5.31217124947e-05 ko03040 Spliceosome 2/710 145/7206 5.99497190651e-05 ko04925 Aldosterone synthesis and secretion 23/710 105/7206 0.000192847208923 ko00010 Glycolysis / Gluconeogenesis 18/710 74/7206 0.000222958412529 ko04270 Vascular smooth muscle contraction 30/710 154/7206 0.00028443958709 ko05203 Viral carcinogenesis 11/710 277/7206 0.000291210418161 ko03013 RNA transport 4/710 166/7206 0.000304769107966 ko04971 Gastric acid secretion 21/710 98/7206 0.000491414445339 ko05031 Amphetamine addiction 20/710 91/7206 0.000511541266682 ko04720 Long-term potentiation 21/710 99/7206 0.000558267632858 ko04728 Dopaminergic synapse 33/710 185/7206 0.000645037712261 ko04080 Neuroactive ligand-receptor interaction 63/710 423/7206 0.000717687819802 ko04730 Long-term depression 18/710 78/7206 0.000740021936248 ko01200 Carbon metabolism 25/710 128/7206 0.000782521796733 ko04727 GABAergic synapse 22/710 110/7206 0.00104426699812 ko04626 Plant-pathogen interaction 7/710 18/7206 0.00105339877597 ko04725 Cholinergic synapse 29/710 160/7206 0.00109813779649 ko04924 Renin secretion 18/710 86/7206 0.00164046992116 ko00051 Fructose and mannose metabolism 11/710 42/7206 0.00193815100271 ko04726 Serotonergic synapse 25/710 137/7206 0.00209795325942 ko05230 Central carbon metabolism in cancer 17/710 81/7206 0.0021777185265 ko04137 Mitophagy - animal 17/710 82/7206 0.002449027511 ko04261 Adrenergic signaling in cardiomyocytes 34/710 205/7206 0.00265594386189 ko04014 Ras signaling pathway 43/710 279/7206 0.00278073368106 ko04650 Natural killer cell mediated cytotoxicity 19/710 97/7206 0.00302385457599 ko00620 Pyruvate metabolism 11/710 46/7206 0.00419793389192 ko00680 Methane metabolism 9/710 34/7206 0.00454858659343 ko01230 Biosynthesis of amino acids 17/710 85/7206 0.00482232226563 ko04015 Rap1 signaling pathway 42/710 278/7206 0.00526268882844 ko04960 Aldosterone-regulated sodium reabsorption 10/710 41/7206 0.00536479430987 ko04964 Proximal tubule bicarbonate reclamation 8/710 29/7206 0.0056098102271 ko01212 Fatty acid metabolism 13/710 60/7206 0.00676285895129 ko04110 Cell cycle 5/710 145/7206 0.0067662734862 ko00592 alpha-Linolenic acid metabolism 6/710 19/7206 0.00791234844668 ko04141 Protein processing in endoplasmic reticulum 8/710 184/7206 0.00812303995443 ko01040 Biosynthesis of unsaturated fatty acids 7/710 25/7206 0.00863522203667 ko05167 Kaposi's sarcoma-associated herpesvirus infection 30/710 191/7206 0.00930093779755 ko00120 Primary bile acid biosynthesis 6/710 20/7206 0.0103805943902 ko00071 Fatty acid degradation 10/710 45/7206 0.0106601969931 ko04657 IL-17 signaling pathway 2/710 87/7206 0.0107433183973 ko04966 Collecting duct acid secretion 7/710 26/7206 0.0108357814764 ko05010 Alzheimer's disease 31/710 202/7206 0.0114906239348 ko05322 Systemic lupus erythematosus 6/710 151/7206 0.0121226182683 ko04066 HIF-1 signaling pathway 21/710 123/7206 0.013291606475 ko00710 Carbon fixation in photosynthetic organisms 7/710 27/7206 0.0134164124707 ko04024 cAMP signaling pathway 40/710 279/7206 0.0136768013121 ko05032 Morphine addiction 19/710 110/7206 0.0143387850602 ko00362 Benzoate degradation 3/710 6/7206 0.0151698221361 ko04919 Thyroid hormone signaling pathway 23/710 143/7206 0.0157279452347 ko04540 Gap junction 21/710 128/7206 0.0164363624493 ko04068 FoxO signaling pathway 26/710 167/7206 0.0173369943083 ko05323 Rheumatoid arthritis 16/710 89/7206 0.0178704771942 ko00562 Inositol phosphate metabolism 16/710 89/7206 0.0178704771942 ko00020 Citrate cycle (TCA cycle) 8/710 35/7206 0.0181655383143 ko05033 Nicotine addiction 11/710 56/7206 0.0219252802269 ko00240 Pyrimidine metabolism 4/710 110/7206 0.0231686309873 ko04550 Signaling pathways regulating pluripotency of stem cells 8/710 165/7206 0.0245789342139 ko04072 Phospholipase D signaling pathway 29/710 197/7206 0.0280971354304 ko04136 Autophagy - other 7/710 31/7206 0.028160727775 ko04723 Retrograde endocannabinoid signaling 26/710 175/7206 0.0289850415988 ko05130 Pathogenic Escherichia coli infection 2/710 77/7206 0.0317216554915 ko05214 Glioma 14/710 79/7206 0.0334840580401 ko00190 Oxidative phosphorylation 20/710 127/7206 0.0338747372091 ko04721 Synaptic vesicle cycle 14/710 80/7206 0.0347345396374 ko04350 TGF-beta signaling pathway 4/710 103/7206 0.0435640955699