ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	190/1149	423/7206	2.11469011413e-48
ko04724	Glutamatergic synapse	86/1149	152/7206	4.28649096202e-31
ko05033	Nicotine addiction	47/1149	56/7206	2.60132895125e-29
ko05032	Morphine addiction	65/1149	110/7206	3.38927518486e-25
ko04713	Circadian entrainment	72/1149	136/7206	8.56984709319e-24
ko04727	GABAergic synapse	63/1149	110/7206	2.02235110867e-23
ko04721	Synaptic vesicle cycle	51/1149	80/7206	3.82712393266e-22
ko04728	Dopaminergic synapse	84/1149	185/7206	8.80443644732e-22
ko04725	Cholinergic synapse	73/1149	160/7206	3.30013393243e-19
ko04723	Retrograde endocannabinoid signaling	76/1149	175/7206	2.10868447733e-18
ko04742	Taste transduction	39/1149	61/7206	2.78382656656e-17
ko04024	cAMP signaling pathway	100/1149	279/7206	1.0254893019e-16
ko04020	Calcium signaling pathway	96/1149	265/7206	2.7964276491e-16
ko04921	Oxytocin signaling pathway	81/1149	209/7206	6.36719809967e-16
ko04911	Insulin secretion	52/1149	117/7206	1.86566377372e-13
ko04726	Serotonergic synapse	56/1149	137/7206	1.55169518473e-12
ko04261	Adrenergic signaling in cardiomyocytes	73/1149	205/7206	2.51154687249e-12
ko05031	Amphetamine addiction	41/1149	91/7206	4.08907594706e-11
ko04720	Long-term potentiation	43/1149	99/7206	5.98784448716e-11
ko04970	Salivary secretion	41/1149	95/7206	2.1383890174e-10
ko03040	Spliceosome	1/1149	145/7206	5.2492262568e-10
ko04744	Phototransduction	22/1149	36/7206	9.46707057016e-10
ko05168	Herpes simplex infection	5/1149	182/7206	1.31685659343e-08
ko05203	Viral carcinogenesis	15/1149	277/7206	5.99819746206e-08
ko04360	Axon guidance	69/1149	233/7206	8.72447403549e-08
ko04925	Aldosterone synthesis and secretion	39/1149	105/7206	1.01667601917e-07
ko04060	Cytokine-cytokine receptor interaction	7/1149	191/7206	1.04499243747e-07
ko04022	cGMP-PKG signaling pathway	65/1149	216/7206	1.24848587011e-07
ko04971	Gastric acid secretion	36/1149	98/7206	4.27196589671e-07
ko04966	Collecting duct acid secretion	15/1149	26/7206	1.35519098132e-06
ko04924	Renin secretion	32/1149	86/7206	1.53765767496e-06
ko03013	RNA transport	7/1149	166/7206	2.80905863461e-06
ko05164	Influenza A	7/1149	167/7206	2.84288539523e-06
ko05030	Cocaine addiction	28/1149	73/7206	2.8548468086e-06
ko04740	Olfactory transduction	30/1149	80/7206	3.05403268184e-06
ko04010	MAPK signaling pathway	83/1149	321/7206	3.40505542278e-06
ko05322	Systemic lupus erythematosus	6/1149	151/7206	4.95399772033e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1149	74/7206	1.51953928756e-05
ko04260	Cardiac muscle contraction	33/1149	98/7206	1.75967905104e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1149	79/7206	1.76656467968e-05
ko04514	Cell adhesion molecules (CAMs)	40/1149	130/7206	1.76793416884e-05
ko04621	NOD-like receptor signaling pathway	8/1149	157/7206	3.66191078362e-05
ko05161	Hepatitis B	10/1149	173/7206	5.53252235415e-05
ko04141	Protein processing in endoplasmic reticulum	11/1149	184/7206	5.65562903845e-05
ko05169	Epstein-Barr virus infection	14/1149	206/7206	9.76608195529e-05
ko04745	Phototransduction - fly	16/1149	38/7206	0.00010633874866
ko04972	Pancreatic secretion	34/1149	111/7206	0.000109141685171
ko05414	Dilated cardiomyopathy	34/1149	112/7206	0.000120358282812
ko04730	Long-term depression	26/1149	78/7206	0.000128174473399
ko04120	Ubiquitin mediated proteolysis	7/1149	138/7206	0.00013734288636
ko05205	Proteoglycans in cancer	22/1149	271/7206	0.000177658289778
ko05110	Vibrio cholerae infection	22/1149	63/7206	0.00018593134723
ko03008	Ribosome biogenesis in eukaryotes	2/1149	79/7206	0.000269489541031
ko04976	Bile secretion	26/1149	80/7206	0.000287030253481
ko05140	Leishmaniasis	2/1149	75/7206	0.000387237299382
ko04612	Antigen processing and presentation	2/1149	77/7206	0.00041271336742
ko04110	Cell cycle	9/1149	145/7206	0.000524367504784
ko04014	Ras signaling pathway	66/1149	279/7206	0.00059853910372
ko04064	NF-kappa B signaling pathway	4/1149	96/7206	0.000606819015915
ko04070	Phosphatidylinositol signaling system	32/1149	112/7206	0.000618764593198
ko04626	Plant-pathogen interaction	9/1149	18/7206	0.000798208146823
ko04540	Gap junction	35/1149	128/7206	0.000889329596749
ko04964	Proximal tubule bicarbonate reclamation	12/1149	29/7206	0.000936441446522
ko05162	Measles	7/1149	120/7206	0.0010025885088
ko04630	Jak-STAT signaling pathway	8/1149	132/7206	0.0010374088722
ko04371	Apelin signaling pathway	45/1149	177/7206	0.00114697092618
ko04146	Peroxisome	4/1149	89/7206	0.00121344908308
ko00480	Glutathione metabolism	1/1149	55/7206	0.00132754723839
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1149	59/7206	0.00184504628841
ko00590	Arachidonic acid metabolism	1/1149	52/7206	0.00199489971217
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1149	100/7206	0.00215061037924
ko04923	Regulation of lipolysis in adipocytes	23/1149	77/7206	0.0024254491239
ko04640	Hematopoietic cell lineage	2/1149	64/7206	0.00286711867974
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1149	14/7206	0.00313842873597
ko04214	Apoptosis - fly	3/1149	72/7206	0.00319480841434
ko04915	Estrogen signaling pathway	34/1149	131/7206	0.00349495359005
ko00240	Pyrimidine metabolism	7/1149	110/7206	0.00361039915543
ko04072	Phospholipase D signaling pathway	47/1149	197/7206	0.00397428371979
ko05166	HTLV-I infection	30/1149	292/7206	0.00546600051603
ko04750	Inflammatory mediator regulation of TRP channels	31/1149	122/7206	0.00591959717366
ko03022	Basal transcription factors	1/1149	44/7206	0.00676167254138
ko04140	Autophagy - animal	14/1149	164/7206	0.00678253126608
ko05144	Malaria	1/1149	45/7206	0.00680065774471
ko00071	Fatty acid degradation	1/1149	45/7206	0.00680065774471
ko03420	Nucleotide excision repair	1/1149	46/7206	0.00707691921808
ko05215	Prostate cancer	8/1149	111/7206	0.0086039572423
ko05321	Inflammatory bowel disease (IBD)	2/1149	56/7206	0.00886799319781
ko05206	MicroRNAs in cancer	16/1149	177/7206	0.00913176080505
ko00310	Lysine degradation	4/1149	73/7206	0.00977350871857
ko04115	p53 signaling pathway	4/1149	74/7206	0.00983811728755
ko03018	RNA degradation	5/1149	84/7206	0.00994410917649
ko05222	Small cell lung cancer	6/1149	89/7206	0.0130089070713
ko04210	Apoptosis	17/1149	180/7206	0.0132525235986
ko05145	Toxoplasmosis	10/1149	126/7206	0.0133344452163
ko00330	Arginine and proline metabolism	3/1149	61/7206	0.0133598619391
ko04622	RIG-I-like receptor signaling pathway	3/1149	62/7206	0.0135068527971
ko05131	Shigellosis	5/1149	82/7206	0.0140069785942
ko00290	Valine, leucine and isoleucine biosynthesis	3/1149	4/7206	0.0142494764632
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1149	40/7206	0.0152774374265
ko00140	Steroid hormone biosynthesis	1/1149	41/7206	0.0159536679019
ko04657	IL-17 signaling pathway	6/1149	87/7206	0.017709381101
ko05133	Pertussis	6/1149	87/7206	0.017709381101
ko00380	Tryptophan metabolism	2/1149	50/7206	0.0181485821565
ko00982	Drug metabolism - cytochrome P450	1/1149	37/7206	0.0225849533869
ko04668	TNF signaling pathway	10/1149	120/7206	0.022672580278
ko04933	AGE-RAGE signaling pathway in diabetic complications	12/1149	135/7206	0.0234763111147
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1149	182/7206	0.0235971933271
ko04930	Type II diabetes mellitus	15/1149	54/7206	0.0240105616505
ko04270	Vascular smooth muscle contraction	35/1149	154/7206	0.0255325037821
ko01524	Platinum drug resistance	5/1149	76/7206	0.0259000526425
ko05418	Fluid shear stress and atherosclerosis	17/1149	173/7206	0.0267039250441
ko05219	Bladder cancer	2/1149	48/7206	0.0268391870495
ko04620	Toll-like receptor signaling pathway	8/1149	100/7206	0.0271578756106
ko04922	Glucagon signaling pathway	30/1149	128/7206	0.0273713154677
ko04217	Necroptosis	18/1149	178/7206	0.0293993985895
ko00860	Porphyrin and chlorophyll metabolism	1/1149	34/7206	0.0334811492284
ko00280	Valine, leucine and isoleucine degradation	3/1149	54/7206	0.0380962331489
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1149	92/7206	0.0438322723368
ko04912	GnRH signaling pathway	28/1149	122/7206	0.0447340702422
ko04114	Oocyte meiosis	31/1149	139/7206	0.0460549284648
ko03320	PPAR signaling pathway	5/1149	69/7206	0.0469501694337
ko04658	Th1 and Th2 cell differentiation	8/1149	96/7206	0.0478323393193
ko04510	Focal adhesion	27/1149	240/7206	0.0479578321939
ko04136	Autophagy - other	1/1149	31/7206	0.0497139824732