ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	193/1105	423/7206	2.28897083825e-53
ko04724	Glutamatergic synapse	89/1105	152/7206	4.00034647765e-35
ko05033	Nicotine addiction	49/1105	56/7206	3.8911530313e-33
ko05032	Morphine addiction	69/1105	110/7206	4.99808766087e-30
ko04713	Circadian entrainment	76/1105	136/7206	3.06396944067e-28
ko04727	GABAergic synapse	67/1105	110/7206	4.46981819881e-28
ko04728	Dopaminergic synapse	86/1105	185/7206	2.3786183781e-24
ko04725	Cholinergic synapse	75/1105	160/7206	1.26445919633e-21
ko04723	Retrograde endocannabinoid signaling	77/1105	175/7206	4.3474126798e-20
ko04024	cAMP signaling pathway	104/1105	279/7206	4.35996390388e-20
ko04721	Synaptic vesicle cycle	48/1105	80/7206	4.98142441391e-20
ko04911	Insulin secretion	57/1105	117/7206	1.11709626385e-17
ko04020	Calcium signaling pathway	93/1105	265/7206	4.64795730561e-16
ko04726	Serotonergic synapse	59/1105	137/7206	3.93848968873e-15
ko04742	Taste transduction	36/1105	61/7206	5.18085059744e-15
ko04744	Phototransduction	26/1105	36/7206	2.78533117469e-14
ko04921	Oxytocin signaling pathway	74/1105	209/7206	3.20600945088e-13
ko05031	Amphetamine addiction	43/1105	91/7206	4.66216046345e-13
ko04261	Adrenergic signaling in cardiomyocytes	71/1105	205/7206	3.86386823744e-12
ko04720	Long-term potentiation	43/1105	99/7206	1.60317154285e-11
ko04740	Olfactory transduction	36/1105	80/7206	2.17234586096e-10
ko04970	Salivary secretion	40/1105	95/7206	2.62246405688e-10
ko03040	Spliceosome	1/1105	145/7206	1.36792289582e-09
ko05030	Cocaine addiction	32/1105	73/7206	4.92919669803e-09
ko04925	Aldosterone synthesis and secretion	40/1105	105/7206	8.82026862353e-09
ko04971	Gastric acid secretion	37/1105	98/7206	4.21272197094e-08
ko04360	Axon guidance	68/1105	233/7206	4.74190870859e-08
ko05203	Viral carcinogenesis	14/1105	277/7206	8.81076686431e-08
ko04060	Cytokine-cytokine receptor interaction	7/1105	191/7206	3.57037379422e-07
ko05322	Systemic lupus erythematosus	4/1105	151/7206	4.94181409018e-07
ko04010	MAPK signaling pathway	83/1105	321/7206	6.73408086501e-07
ko05168	Herpes simplex infection	7/1105	182/7206	1.03631786047e-06
ko04022	cGMP-PKG signaling pathway	61/1105	216/7206	1.09324011896e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1105	74/7206	1.77104720291e-06
ko04745	Phototransduction - fly	18/1105	38/7206	3.01329558799e-06
ko03013	RNA transport	7/1105	166/7206	9.10860128278e-06
ko04972	Pancreatic secretion	35/1105	111/7206	1.41193022355e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1105	79/7206	2.59960621675e-05
ko05164	Influenza A	8/1105	167/7206	2.78626459578e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1105	59/7206	2.9482842241e-05
ko04141	Protein processing in endoplasmic reticulum	10/1105	184/7206	4.25044334458e-05
ko04621	NOD-like receptor signaling pathway	8/1105	157/7206	7.62914638207e-05
ko04730	Long-term depression	26/1105	78/7206	8.81742749203e-05
ko04260	Cardiac muscle contraction	30/1105	98/7206	0.000106598391118
ko04514	Cell adhesion molecules (CAMs)	37/1105	130/7206	0.000110504443256
ko04072	Phospholipase D signaling pathway	51/1105	197/7206	0.000116149725654
ko04014	Ras signaling pathway	67/1105	279/7206	0.000121222433253
ko04540	Gap junction	36/1105	128/7206	0.000170939353843
ko04924	Renin secretion	27/1105	86/7206	0.000206335544294
ko05414	Dilated cardiomyopathy	32/1105	112/7206	0.00029384439754
ko04070	Phosphatidylinositol signaling system	32/1105	112/7206	0.00029384439754
ko05110	Vibrio cholerae infection	21/1105	63/7206	0.000309721820153
ko04750	Inflammatory mediator regulation of TRP channels	34/1105	122/7206	0.000325455280887
ko04110	Cell cycle	8/1105	145/7206	0.00040434872344
ko03008	Ribosome biogenesis in eukaryotes	2/1105	79/7206	0.000411346700637
ko04612	Antigen processing and presentation	2/1105	77/7206	0.000625250015067
ko05162	Measles	6/1105	120/7206	0.00075044066061
ko04976	Bile secretion	24/1105	80/7206	0.000819953024802
ko04966	Collecting duct acid secretion	11/1105	26/7206	0.000875753365498
ko05205	Proteoglycans in cancer	23/1105	271/7206	0.00102010972138
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1105	182/7206	0.00113278576917
ko04915	Estrogen signaling pathway	34/1105	131/7206	0.00135223540968
ko04371	Apelin signaling pathway	43/1105	177/7206	0.00145660438325
ko05169	Epstein-Barr virus infection	16/1105	206/7206	0.00156629570693
ko00480	Glutathione metabolism	1/1105	55/7206	0.00209222955135
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1105	14/7206	0.0024898309366
ko04120	Ubiquitin mediated proteolysis	9/1105	138/7206	0.00259479968299
ko04146	Peroxisome	4/1105	89/7206	0.00262767570104
ko04640	Hematopoietic cell lineage	2/1105	64/7206	0.00279806289665
ko05140	Leishmaniasis	3/1105	75/7206	0.00330363215295
ko04064	NF-kappa B signaling pathway	5/1105	96/7206	0.00384465595326
ko04350	TGF-beta signaling pathway	6/1105	103/7206	0.00531941871328
ko05161	Hepatitis B	14/1105	173/7206	0.00536122603367
ko03420	Nucleotide excision repair	1/1105	46/7206	0.00693817041068
ko00240	Pyrimidine metabolism	7/1105	110/7206	0.00704616572205
ko04912	GnRH signaling pathway	30/1105	122/7206	0.00725709786689
ko00260	Glycine, serine and threonine metabolism	1/1105	48/7206	0.00735477155042
ko05219	Bladder cancer	1/1105	48/7206	0.00735477155042
ko05166	HTLV-I infection	29/1105	292/7206	0.00780656722267
ko04015	Rap1 signaling pathway	59/1105	278/7206	0.00824211992332
ko04964	Proximal tubule bicarbonate reclamation	10/1105	29/7206	0.00854022192034
ko05321	Inflammatory bowel disease (IBD)	2/1105	56/7206	0.00867672247305
ko04973	Carbohydrate digestion and absorption	13/1105	42/7206	0.00895968404679
ko04630	Jak-STAT signaling pathway	10/1105	132/7206	0.0101026384148
ko04657	IL-17 signaling pathway	5/1105	87/7206	0.0101279530855
ko03022	Basal transcription factors	1/1105	44/7206	0.0104233602495
ko05144	Malaria	1/1105	45/7206	0.0107864582119
ko00071	Fatty acid degradation	1/1105	45/7206	0.0107864582119
ko04140	Autophagy - animal	14/1105	164/7206	0.0116072073601
ko04626	Plant-pathogen interaction	7/1105	18/7206	0.0131949586828
ko03018	RNA degradation	5/1105	84/7206	0.0139126269541
ko00310	Lysine degradation	4/1105	73/7206	0.0140031606721
ko04217	Necroptosis	16/1105	178/7206	0.015179410641
ko04923	Regulation of lipolysis in adipocytes	20/1105	77/7206	0.0157063577767
ko05215	Prostate cancer	8/1105	111/7206	0.0159892578885
ko00330	Arginine and proline metabolism	3/1105	61/7206	0.0193901812246
ko05131	Shigellosis	5/1105	82/7206	0.0194084119971
ko04622	RIG-I-like receptor signaling pathway	3/1105	62/7206	0.0197174982464
ko04214	Apoptosis - fly	4/1105	72/7206	0.0198736070851
ko05016	Huntington's disease	21/1105	215/7206	0.020740900088
ko04918	Thyroid hormone synthesis	21/1105	86/7206	0.0236383241535
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1105	100/7206	0.0240519830886
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1105	40/7206	0.0243487053962
ko05418	Fluid shear stress and atherosclerosis	16/1105	173/7206	0.0243717710213
ko05133	Pertussis	6/1105	87/7206	0.0244024677223
ko04960	Aldosterone-regulated sodium reabsorption	12/1105	41/7206	0.0260257437695
ko04210	Apoptosis	17/1105	180/7206	0.0272066822107
ko05034	Alcoholism	49/1105	238/7206	0.0276800083626
ko04658	Th1 and Th2 cell differentiation	7/1105	96/7206	0.0309784354064
ko05206	MicroRNAs in cancer	17/1105	177/7206	0.0339942566351
ko04975	Fat digestion and absorption	1/1105	35/7206	0.0341117821667
ko04115	p53 signaling pathway	5/1105	74/7206	0.0352859580466
ko00982	Drug metabolism - cytochrome P450	1/1105	37/7206	0.035553987519
ko01524	Platinum drug resistance	5/1105	76/7206	0.0357691609426
ko04062	Chemokine signaling pathway	42/1105	201/7206	0.0363514237671
ko04930	Type II diabetes mellitus	14/1105	54/7206	0.0368423277239
ko00562	Inositol phosphate metabolism	21/1105	89/7206	0.0372533269716
ko00620	Pyruvate metabolism	2/1105	46/7206	0.0380358082796
ko00270	Cysteine and methionine metabolism	2/1105	47/7206	0.0390640451328
ko04270	Vascular smooth muscle contraction	33/1105	154/7206	0.0411733668565
ko04137	Mitophagy - animal	6/1105	82/7206	0.0440559209756
ko05145	Toxoplasmosis	11/1105	126/7206	0.0447070282626
ko04071	Sphingolipid signaling pathway	34/1105	162/7206	0.0472279101118
ko04620	Toll-like receptor signaling pathway	8/1105	100/7206	0.0487455486184