ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	198/1162	423/7206	2.86495096449e-53
ko05033	Nicotine addiction	50/1162	56/7206	1.1635887653e-33
ko04724	Glutamatergic synapse	89/1162	152/7206	2.35262169546e-33
ko05032	Morphine addiction	70/1162	110/7206	1.30153885512e-29
ko04713	Circadian entrainment	79/1162	136/7206	2.32989735136e-29
ko04727	GABAergic synapse	67/1162	110/7206	9.67612246174e-27
ko04728	Dopaminergic synapse	85/1162	185/7206	4.0557392944e-22
ko04725	Cholinergic synapse	76/1162	160/7206	5.76369116963e-21
ko04723	Retrograde endocannabinoid signaling	79/1162	175/7206	4.88039969314e-20
ko04024	cAMP signaling pathway	104/1162	279/7206	2.19748707003e-18
ko04020	Calcium signaling pathway	100/1162	265/7206	3.48926285018e-18
ko04742	Taste transduction	39/1162	61/7206	4.15440312268e-17
ko04744	Phototransduction	28/1162	36/7206	3.95160642626e-16
ko04911	Insulin secretion	56/1162	117/7206	6.20380549554e-16
ko04721	Synaptic vesicle cycle	44/1162	80/7206	1.25279915081e-15
ko04726	Serotonergic synapse	61/1162	137/7206	2.22212579526e-15
ko04921	Oxytocin signaling pathway	78/1162	209/7206	4.38687698786e-14
ko04740	Olfactory transduction	41/1162	80/7206	2.8822092864e-13
ko04261	Adrenergic signaling in cardiomyocytes	73/1162	205/7206	5.63694660186e-12
ko05031	Amphetamine addiction	42/1162	91/7206	1.29598192247e-11
ko04970	Salivary secretion	42/1162	95/7206	7.25827762026e-11
ko04720	Long-term potentiation	43/1162	99/7206	8.72162638166e-11
ko03040	Spliceosome	1/1162	145/7206	3.14582301038e-10
ko04360	Axon guidance	74/1162	233/7206	1.7811948327e-09
ko05203	Viral carcinogenesis	13/1162	277/7206	3.11047046627e-09
ko05030	Cocaine addiction	32/1162	73/7206	1.74316100469e-08
ko04925	Aldosterone synthesis and secretion	40/1162	105/7206	4.6166292539e-08
ko04022	cGMP-PKG signaling pathway	65/1162	216/7206	2.42236993013e-07
ko04971	Gastric acid secretion	36/1162	98/7206	5.48635112794e-07
ko05322	Systemic lupus erythematosus	5/1162	151/7206	8.85659045115e-07
ko03013	RNA transport	7/1162	166/7206	2.87105371248e-06
ko05168	Herpes simplex infection	9/1162	182/7206	5.01418510199e-06
ko04010	MAPK signaling pathway	83/1162	321/7206	5.53443082096e-06
ko04745	Phototransduction - fly	18/1162	38/7206	6.30299633385e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1162	74/7206	6.96543568849e-06
ko05164	Influenza A	8/1162	167/7206	9.16673504826e-06
ko04141	Protein processing in endoplasmic reticulum	10/1162	184/7206	1.50479584723e-05
ko04514	Cell adhesion molecules (CAMs)	40/1162	130/7206	2.97816499376e-05
ko04120	Ubiquitin mediated proteolysis	6/1162	138/7206	3.09715313175e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1162	79/7206	3.46226520473e-05
ko04621	NOD-like receptor signaling pathway	8/1162	157/7206	3.72920524518e-05
ko04540	Gap junction	39/1162	128/7206	4.54558950093e-05
ko04060	Cytokine-cytokine receptor interaction	12/1162	191/7206	5.50308209167e-05
ko04072	Phospholipase D signaling pathway	53/1162	197/7206	0.000107280395145
ko04972	Pancreatic secretion	34/1162	111/7206	0.000121681209368
ko05414	Dilated cardiomyopathy	34/1162	112/7206	0.000137606448508
ko04110	Cell cycle	8/1162	145/7206	0.000139549594149
ko04750	Inflammatory mediator regulation of TRP channels	36/1162	122/7206	0.00016456630201
ko03008	Ribosome biogenesis in eukaryotes	2/1162	79/7206	0.000173831360937
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1162	59/7206	0.000234453624597
ko04612	Antigen processing and presentation	2/1162	77/7206	0.000257772112834
ko04260	Cardiac muscle contraction	30/1162	98/7206	0.000274080094511
ko04924	Renin secretion	27/1162	86/7206	0.000340930957799
ko04070	Phosphatidylinositol signaling system	33/1162	112/7206	0.000377645515345
ko05140	Leishmaniasis	2/1162	75/7206	0.000386018735369
ko04064	NF-kappa B signaling pathway	4/1162	96/7206	0.000406563603151
ko04014	Ras signaling pathway	67/1162	279/7206	0.000467712207607
ko04730	Long-term depression	25/1162	78/7206	0.000483978661415
ko05169	Epstein-Barr virus infection	16/1162	206/7206	0.000492805515265
ko05205	Proteoglycans in cancer	24/1162	271/7206	0.000524112920515
ko04976	Bile secretion	25/1162	80/7206	0.000637699756513
ko04371	Apelin signaling pathway	46/1162	177/7206	0.0008303362889
ko05162	Measles	7/1162	120/7206	0.000995944098156
ko04610	Complement and coagulation cascades	3/1162	79/7206	0.00104734264189
ko00520	Amino sugar and nucleotide sugar metabolism	1/1162	55/7206	0.00133210311162
ko00480	Glutathione metabolism	1/1162	55/7206	0.00133210311162
ko05161	Hepatitis B	14/1162	173/7206	0.00230820139891
ko04923	Regulation of lipolysis in adipocytes	23/1162	77/7206	0.00256375809331
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1162	14/7206	0.00335371424008
ko00240	Pyrimidine metabolism	7/1162	110/7206	0.0036517969126
ko04915	Estrogen signaling pathway	34/1162	131/7206	0.00370538851699
ko00620	Pyruvate metabolism	1/1162	46/7206	0.00447575340854
ko03420	Nucleotide excision repair	1/1162	46/7206	0.00447575340854
ko04658	Th1 and Th2 cell differentiation	6/1162	96/7206	0.00501832484624
ko04657	IL-17 signaling pathway	5/1162	87/7206	0.00502897154513
ko04146	Peroxisome	5/1162	89/7206	0.00521452557469
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1162	182/7206	0.00555255999395
ko05321	Inflammatory bowel disease (IBD)	2/1162	56/7206	0.00574293587992
ko03022	Basal transcription factors	1/1162	44/7206	0.00669612586025
ko05144	Malaria	1/1162	45/7206	0.00685204252176
ko00071	Fatty acid degradation	1/1162	45/7206	0.00685204252176
ko03018	RNA degradation	5/1162	84/7206	0.0070068475128
ko04217	Necroptosis	16/1162	178/7206	0.00706943447525
ko05215	Prostate cancer	8/1162	111/7206	0.00866963121736
ko04640	Hematopoietic cell lineage	3/1162	64/7206	0.00942775504212
ko04142	Lysosome	13/1162	151/7206	0.009705788928
ko04214	Apoptosis - fly	4/1162	72/7206	0.00970974705901
ko05131	Shigellosis	5/1162	82/7206	0.00971249699794
ko00310	Lysine degradation	4/1162	73/7206	0.00973876466901
ko04711	Circadian rhythm - fly	6/1162	13/7206	0.0107071462731
ko04630	Jak-STAT signaling pathway	11/1162	132/7206	0.0117677776435
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1162	100/7206	0.0127738805102
ko04210	Apoptosis	17/1162	180/7206	0.01329938503
ko00330	Arginine and proline metabolism	3/1162	61/7206	0.0133353842218
ko04622	RIG-I-like receptor signaling pathway	3/1162	62/7206	0.013684914536
ko05166	HTLV-I infection	32/1162	292/7206	0.0145125127656
ko04015	Rap1 signaling pathway	60/1162	278/7206	0.0155526960017
ko04626	Plant-pathogen interaction	7/1162	18/7206	0.017242740718
ko00260	Glycine, serine and threonine metabolism	2/1162	48/7206	0.0177185758308
ko05219	Bladder cancer	2/1162	48/7206	0.0177185758308
ko05133	Pertussis	6/1162	87/7206	0.0178410008437
ko05016	Huntington's disease	22/1162	215/7206	0.0181139402238
ko01524	Platinum drug resistance	5/1162	76/7206	0.0184504054068
ko04710	Circadian rhythm	13/1162	43/7206	0.0197418477059
ko05145	Toxoplasmosis	11/1162	126/7206	0.0200081778233
ko04140	Autophagy - animal	16/1162	164/7206	0.023729161155
ko05110	Vibrio cholerae infection	17/1162	63/7206	0.0246326285019
ko04912	GnRH signaling pathway	29/1162	122/7206	0.0251361395931
ko04115	p53 signaling pathway	5/1162	74/7206	0.0252968818118
ko00270	Cysteine and methionine metabolism	2/1162	47/7206	0.0262120010962
ko04966	Collecting duct acid secretion	9/1162	26/7206	0.0268259740415
ko04620	Toll-like receptor signaling pathway	8/1162	100/7206	0.0273311270991
ko04218	Cellular senescence	18/1162	177/7206	0.0293062734497
ko04137	Mitophagy - animal	6/1162	82/7206	0.0328502587761
ko00640	Propanoate metabolism	1/1162	34/7206	0.0334162506503
ko00860	Porphyrin and chlorophyll metabolism	1/1162	34/7206	0.0334162506503
ko04270	Vascular smooth muscle contraction	35/1162	154/7206	0.0344462435388
ko04330	Notch signaling pathway	4/1162	62/7206	0.0364422865969
ko01200	Carbon metabolism	12/1162	128/7206	0.0384060902852
ko00280	Valine, leucine and isoleucine degradation	3/1162	54/7206	0.0384905797482
ko04964	Proximal tubule bicarbonate reclamation	9/1162	29/7206	0.0399515481352