ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	203/1223	423/7206	5.37548307905e-53
ko05033	Nicotine addiction	50/1223	56/7206	1.49446934016e-32
ko04724	Glutamatergic synapse	89/1223	152/7206	1.41648246128e-31
ko05032	Morphine addiction	70/1223	110/7206	3.49319800861e-28
ko04727	GABAergic synapse	68/1223	110/7206	2.62223651594e-26
ko04713	Circadian entrainment	76/1223	136/7206	2.79144499574e-25
ko04728	Dopaminergic synapse	87/1223	185/7206	6.59006483951e-22
ko04725	Cholinergic synapse	77/1223	160/7206	2.90425912944e-20
ko04721	Synaptic vesicle cycle	50/1223	80/7206	6.06709585122e-20
ko04723	Retrograde endocannabinoid signaling	78/1223	175/7206	5.13871060025e-18
ko04024	cAMP signaling pathway	106/1223	279/7206	1.37297115699e-17
ko04020	Calcium signaling pathway	100/1223	265/7206	1.96321609692e-16
ko04911	Insulin secretion	57/1223	117/7206	1.32931248204e-15
ko04742	Taste transduction	38/1223	61/7206	2.18832043024e-15
ko04726	Serotonergic synapse	59/1223	137/7206	4.10626155581e-13
ko04921	Oxytocin signaling pathway	78/1223	209/7206	7.93057481361e-13
ko04261	Adrenergic signaling in cardiomyocytes	77/1223	205/7206	8.7579414508e-13
ko04744	Phototransduction	25/1223	36/7206	3.96601095693e-12
ko05031	Amphetamine addiction	43/1223	91/7206	1.59684929051e-11
ko04720	Long-term potentiation	45/1223	99/7206	2.83364131481e-11
ko04360	Axon guidance	81/1223	233/7206	2.86066099438e-11
ko03040	Spliceosome	1/1223	145/7206	7.13032642724e-11
ko04970	Salivary secretion	42/1223	95/7206	3.83987657137e-10
ko04740	Olfactory transduction	36/1223	80/7206	3.87354968495e-09
ko05203	Viral carcinogenesis	15/1223	277/7206	6.53397679312e-09
ko04925	Aldosterone synthesis and secretion	41/1223	105/7206	5.28689847435e-08
ko05030	Cocaine addiction	32/1223	73/7206	6.15024517514e-08
ko03013	RNA transport	6/1223	166/7206	1.55854873517e-07
ko05168	Herpes simplex infection	8/1223	182/7206	3.38202123665e-07
ko04060	Cytokine-cytokine receptor interaction	9/1223	191/7206	3.86574165934e-07
ko04971	Gastric acid secretion	37/1223	98/7206	8.33071175415e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1223	74/7206	1.23083529736e-06
ko04022	cGMP-PKG signaling pathway	65/1223	216/7206	1.24529080553e-06
ko05322	Systemic lupus erythematosus	6/1223	151/7206	1.49461216573e-06
ko04010	MAPK signaling pathway	87/1223	321/7206	2.96081054557e-06
ko05164	Influenza A	9/1223	167/7206	8.94723461314e-06
ko04610	Complement and coagulation cascades	1/1223	79/7206	1.26962307798e-05
ko04924	Renin secretion	31/1223	86/7206	1.67073749086e-05
ko04141	Protein processing in endoplasmic reticulum	12/1223	184/7206	3.70202266815e-05
ko04120	Ubiquitin mediated proteolysis	7/1223	138/7206	4.575619536e-05
ko04745	Phototransduction - fly	17/1223	38/7206	5.75606647806e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1223	79/7206	6.05381900638e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1223	59/7206	6.13798986318e-05
ko04540	Gap junction	40/1223	128/7206	6.61528790226e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1223	79/7206	0.000110791827858
ko05140	Leishmaniasis	2/1223	75/7206	0.000162697475551
ko04014	Ras signaling pathway	72/1223	279/7206	0.000164674402865
ko04972	Pancreatic secretion	35/1223	111/7206	0.00016662213294
ko05414	Dilated cardiomyopathy	35/1223	112/7206	0.000183149219005
ko04070	Phosphatidylinositol signaling system	35/1223	112/7206	0.000183149219005
ko04514	Cell adhesion molecules (CAMs)	39/1223	130/7206	0.0002109310036
ko05205	Proteoglycans in cancer	25/1223	271/7206	0.000268744857758
ko04260	Cardiac muscle contraction	31/1223	98/7206	0.000336593139464
ko04621	NOD-like receptor signaling pathway	11/1223	157/7206	0.000342370067285
ko04730	Long-term depression	26/1223	78/7206	0.000375045345156
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1223	182/7206	0.00040959850791
ko00240	Pyrimidine metabolism	6/1223	110/7206	0.000464516992318
ko04966	Collecting duct acid secretion	12/1223	26/7206	0.000504849920176
ko05110	Vibrio cholerae infection	22/1223	63/7206	0.000531009381122
ko04146	Peroxisome	4/1223	89/7206	0.000550827615943
ko04750	Inflammatory mediator regulation of TRP channels	36/1223	122/7206	0.00055726659706
ko04612	Antigen processing and presentation	3/1223	77/7206	0.000681927965294
ko04072	Phospholipase D signaling pathway	52/1223	197/7206	0.000701617982694
ko04976	Bile secretion	26/1223	80/7206	0.000759689063288
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1223	14/7206	0.000769158017161
ko00480	Glutathione metabolism	1/1223	55/7206	0.00084462900272
ko04064	NF-kappa B signaling pathway	5/1223	96/7206	0.000873288735597
ko05169	Epstein-Barr virus infection	18/1223	206/7206	0.000905049654576
ko04371	Apelin signaling pathway	47/1223	177/7206	0.00110034963569
ko04640	Hematopoietic cell lineage	2/1223	64/7206	0.0011830347538
ko00590	Arachidonic acid metabolism	1/1223	52/7206	0.00125104090376
ko05162	Measles	8/1223	120/7206	0.00129264678777
ko04915	Estrogen signaling pathway	37/1223	131/7206	0.00133610467661
ko00330	Arginine and proline metabolism	2/1223	61/7206	0.00173215687119
ko05161	Hepatitis B	15/1223	173/7206	0.00202302576886
ko04110	Cell cycle	12/1223	145/7206	0.00345212070256
ko01200	Carbon metabolism	10/1223	128/7206	0.00403895207019
ko03022	Basal transcription factors	1/1223	44/7206	0.00427790691761
ko05144	Malaria	1/1223	45/7206	0.00433898587208
ko03420	Nucleotide excision repair	1/1223	46/7206	0.00458269338004
ko03018	RNA degradation	5/1223	84/7206	0.00490771462311
ko04923	Regulation of lipolysis in adipocytes	23/1223	77/7206	0.00527449485863
ko04626	Plant-pathogen interaction	8/1223	18/7206	0.00592101193629
ko04622	RIG-I-like receptor signaling pathway	3/1223	62/7206	0.00627781678689
ko00983	Drug metabolism - other enzymes	1/1223	42/7206	0.00644670730148
ko04214	Apoptosis - fly	4/1223	72/7206	0.00667356875159
ko05131	Shigellosis	5/1223	82/7206	0.00696380598498
ko04658	Th1 and Th2 cell differentiation	7/1223	96/7206	0.00876434614977
ko04657	IL-17 signaling pathway	6/1223	87/7206	0.00914754123617
ko05133	Pertussis	6/1223	87/7206	0.00914754123617
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1223	40/7206	0.00977506374709
ko00380	Tryptophan metabolism	2/1223	50/7206	0.0122625237234
ko00982	Drug metabolism - cytochrome P450	1/1223	37/7206	0.0145178051346
ko03410	Base excision repair	1/1223	38/7206	0.0149009733533
ko04620	Toll-like receptor signaling pathway	8/1223	100/7206	0.0149717138437
ko00620	Pyruvate metabolism	2/1223	46/7206	0.0171668519893
ko04015	Rap1 signaling pathway	62/1223	278/7206	0.0180972476061
ko04115	p53 signaling pathway	5/1223	74/7206	0.0182577582797
ko05321	Inflammatory bowel disease (IBD)	3/1223	56/7206	0.0185745980341
ko04964	Proximal tubule bicarbonate reclamation	10/1223	29/7206	0.0216691168456
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1223	100/7206	0.0216879472777
ko00640	Propanoate metabolism	1/1223	34/7206	0.0217572362229
ko05145	Toxoplasmosis	12/1223	126/7206	0.0226078826278
ko04217	Necroptosis	19/1223	178/7206	0.0255072920347
ko00071	Fatty acid degradation	2/1223	45/7206	0.025822591567
ko04630	Jak-STAT signaling pathway	13/1223	132/7206	0.025922820618
ko00280	Valine, leucine and isoleucine degradation	3/1223	54/7206	0.0267778229701
ko04912	GnRH signaling pathway	30/1223	122/7206	0.0283284414526
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1223	26/7206	0.0306011375337
ko01524	Platinum drug resistance	6/1223	76/7206	0.0312519646442
ko04916	Melanogenesis	34/1223	142/7206	0.0313785774047
ko05016	Huntington's disease	25/1223	215/7206	0.0336894845534
ko04391	Hippo signaling pathway - fly	23/1223	90/7206	0.0339747365769
ko04210	Apoptosis	20/1223	180/7206	0.0343337831537
ko00140	Steroid hormone biosynthesis	2/1223	41/7206	0.0360067342383
ko04142	Lysosome	16/1223	151/7206	0.0367398579173
ko04668	TNF signaling pathway	12/1223	120/7206	0.0373619821299
ko04918	Thyroid hormone synthesis	22/1223	86/7206	0.0418018369788
ko05320	Autoimmune thyroid disease	1/1223	29/7206	0.0484265188718