ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	177/1004	423/7206	1.62125957689e-48
ko04724	Glutamatergic synapse	85/1004	152/7206	9.74464269736e-35
ko05033	Nicotine addiction	46/1004	56/7206	1.4978764367e-30
ko05032	Morphine addiction	64/1004	110/7206	1.06380543167e-27
ko04727	GABAergic synapse	63/1004	110/7206	9.52114211046e-27
ko04713	Circadian entrainment	66/1004	136/7206	1.61352476114e-22
ko04723	Retrograde endocannabinoid signaling	75/1004	175/7206	2.59922404171e-21
ko04728	Dopaminergic synapse	77/1004	185/7206	6.53430811699e-21
ko04725	Cholinergic synapse	69/1004	160/7206	7.23108870815e-20
ko04024	cAMP signaling pathway	91/1004	279/7206	3.51846042635e-16
ko04911	Insulin secretion	52/1004	117/7206	6.34618271384e-16
ko04721	Synaptic vesicle cycle	41/1004	80/7206	1.7062694783e-15
ko04020	Calcium signaling pathway	85/1004	265/7206	1.2877719025e-14
ko04726	Serotonergic synapse	55/1004	137/7206	1.93242116742e-14
ko04742	Taste transduction	33/1004	61/7206	1.33123007864e-13
ko04921	Oxytocin signaling pathway	69/1004	209/7206	1.34210690163e-12
ko04261	Adrenergic signaling in cardiomyocytes	64/1004	205/7206	1.04659327787e-10
ko04744	Phototransduction	21/1004	36/7206	6.04520600979e-10
ko04720	Long-term potentiation	38/1004	99/7206	1.05324746222e-09
ko05031	Amphetamine addiction	36/1004	91/7206	1.09663211218e-09
ko03040	Spliceosome	1/1004	145/7206	1.48060054761e-08
ko05030	Cocaine addiction	29/1004	73/7206	4.14054516813e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1004	74/7206	2.39535359455e-07
ko04925	Aldosterone synthesis and secretion	35/1004	105/7206	4.27671602529e-07
ko04970	Salivary secretion	32/1004	95/7206	7.40906540279e-07
ko05203	Viral carcinogenesis	14/1004	277/7206	2.04619280358e-06
ko03013	RNA transport	5/1004	166/7206	3.62156958714e-06
ko04514	Cell adhesion molecules (CAMs)	38/1004	130/7206	4.49826292619e-06
ko04022	cGMP-PKG signaling pathway	55/1004	216/7206	5.14015057864e-06
ko04010	MAPK signaling pathway	74/1004	321/7206	6.90460004421e-06
ko04072	Phospholipase D signaling pathway	51/1004	197/7206	8.39417121079e-06
ko04060	Cytokine-cytokine receptor interaction	8/1004	191/7206	1.12593635203e-05
ko04360	Axon guidance	57/1004	233/7206	1.19986711403e-05
ko04972	Pancreatic secretion	33/1004	111/7206	1.20192143359e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1004	79/7206	1.95879435697e-05
ko04971	Gastric acid secretion	30/1004	98/7206	2.09308155088e-05
ko05322	Systemic lupus erythematosus	5/1004	151/7206	2.25695879479e-05
ko05168	Herpes simplex infection	8/1004	182/7206	3.12479704725e-05
ko05164	Influenza A	7/1004	167/7206	5.85166268195e-05
ko04110	Cell cycle	6/1004	145/7206	0.00014640230056
ko04260	Cardiac muscle contraction	28/1004	98/7206	0.000163332486607
ko03008	Ribosome biogenesis in eukaryotes	1/1004	79/7206	0.000210374117551
ko05414	Dilated cardiomyopathy	30/1004	112/7206	0.000278625582482
ko04070	Phosphatidylinositol signaling system	30/1004	112/7206	0.000278625582482
ko04730	Long-term depression	23/1004	78/7206	0.000372037233307
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1004	59/7206	0.000395180591892
ko04540	Gap junction	33/1004	128/7206	0.000404068840775
ko04740	Olfactory transduction	23/1004	80/7206	0.000479275457269
ko04621	NOD-like receptor signaling pathway	8/1004	157/7206	0.000621503767857
ko05162	Measles	5/1004	120/7206	0.000754172707154
ko04120	Ubiquitin mediated proteolysis	7/1004	138/7206	0.00112934122931
ko04745	Phototransduction - fly	13/1004	38/7206	0.00127284986191
ko04750	Inflammatory mediator regulation of TRP channels	30/1004	122/7206	0.00138793651544
ko05169	Epstein-Barr virus infection	14/1004	206/7206	0.0014966317571
ko04640	Hematopoietic cell lineage	1/1004	64/7206	0.00154985067046
ko04141	Protein processing in endoplasmic reticulum	12/1004	184/7206	0.00232785439622
ko04930	Type II diabetes mellitus	16/1004	54/7206	0.00238684863921
ko04915	Estrogen signaling pathway	31/1004	131/7206	0.00303871076496
ko04976	Bile secretion	21/1004	80/7206	0.00304828415682
ko04137	Mitophagy - animal	3/1004	82/7206	0.00353530579933
ko05205	Proteoglycans in cancer	22/1004	271/7206	0.00403586290008
ko04916	Melanogenesis	32/1004	142/7206	0.00463162283387
ko04014	Ras signaling pathway	55/1004	279/7206	0.00614113230049
ko04630	Jak-STAT signaling pathway	8/1004	132/7206	0.0071459064473
ko04612	Antigen processing and presentation	3/1004	77/7206	0.00726930422828
ko04918	Thyroid hormone synthesis	21/1004	86/7206	0.00751861258547
ko00590	Arachidonic acid metabolism	1/1004	52/7206	0.00756058724286
ko05231	Choline metabolism in cancer	30/1004	134/7206	0.00761854271387
ko04146	Peroxisome	4/1004	89/7206	0.00789205194626
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1004	14/7206	0.00796885763983
ko05161	Hepatitis B	13/1004	173/7206	0.0105062894599
ko03018	RNA degradation	4/1004	84/7206	0.0106066042158
ko04064	NF-kappa B signaling pathway	5/1004	96/7206	0.010763559082
ko04371	Apelin signaling pathway	37/1004	177/7206	0.0109410963419
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1004	182/7206	0.0122349102963
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1004	100/7206	0.012735789846
ko04710	Circadian rhythm	12/1004	43/7206	0.0136717011363
ko00330	Arginine and proline metabolism	2/1004	61/7206	0.01390968283
ko04964	Proximal tubule bicarbonate reclamation	9/1004	29/7206	0.0140329071407
ko00071	Fatty acid degradation	1/1004	45/7206	0.0162709860271
ko00620	Pyruvate metabolism	1/1004	46/7206	0.0165843288177
ko03420	Nucleotide excision repair	1/1004	46/7206	0.0165843288177
ko00240	Pyrimidine metabolism	7/1004	110/7206	0.0178003871077
ko05321	Inflammatory bowel disease (IBD)	2/1004	56/7206	0.0191384189886
ko03320	PPAR signaling pathway	3/1004	69/7206	0.0211560075473
ko04960	Aldosterone-regulated sodium reabsorption	11/1004	41/7206	0.0235315100501
ko04711	Circadian rhythm - fly	5/1004	13/7206	0.025424950686
ko03022	Basal transcription factors	1/1004	44/7206	0.0254819008219
ko05133	Pertussis	5/1004	87/7206	0.02760333352
ko00280	Valine, leucine and isoleucine degradation	2/1004	54/7206	0.0278495800887
ko04115	p53 signaling pathway	4/1004	74/7206	0.028195823698
ko05034	Alcoholism	45/1004	238/7206	0.0283471288709
ko04210	Apoptosis	15/1004	180/7206	0.0286004228892
ko05202	Transcriptional misregulation in cancer	16/1004	188/7206	0.0320407427285
ko04270	Vascular smooth muscle contraction	31/1004	154/7206	0.0332722402208
ko04218	Cellular senescence	15/1004	177/7206	0.0360107086606
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1004	40/7206	0.0361440525159
ko00380	Tryptophan metabolism	2/1004	50/7206	0.0393134811254
ko00310	Lysine degradation	4/1004	73/7206	0.0394105431483
ko04973	Carbohydrate digestion and absorption	11/1004	42/7206	0.0396127694242
ko04550	Signaling pathways regulating pluripotency of stem cells	14/1004	165/7206	0.0403402446132
ko04622	RIG-I-like receptor signaling pathway	3/1004	62/7206	0.040466808273
ko05418	Fluid shear stress and atherosclerosis	15/1004	173/7206	0.0448599310743
ko04923	Regulation of lipolysis in adipocytes	17/1004	77/7206	0.0461108325269
ko04912	GnRH signaling pathway	25/1004	122/7206	0.0465184258691