ko pathway ratio_in_study ratio_in_pop p_value ko04020 Calcium signaling pathway 35/340 265/7206 2.21224145103e-08 ko04710 Circadian rhythm 11/340 43/7206 3.24017339697e-06 ko04724 Glutamatergic synapse 21/340 152/7206 7.98698270613e-06 ko04921 Oxytocin signaling pathway 25/340 209/7206 1.49063885605e-05 ko04727 GABAergic synapse 16/340 110/7206 5.14090180557e-05 ko05032 Morphine addiction 16/340 110/7206 5.14090180557e-05 ko04070 Phosphatidylinositol signaling system 16/340 112/7206 6.42960395563e-05 ko04922 Glucagon signaling pathway 17/340 128/7206 9.73867027772e-05 ko04925 Aldosterone synthesis and secretion 15/340 105/7206 0.000108644163954 ko04080 Neuroactive ligand-receptor interaction 38/340 423/7206 0.000119972366604 ko00010 Glycolysis / Gluconeogenesis 12/340 74/7206 0.000156217033461 ko04725 Cholinergic synapse 19/340 160/7206 0.000176179971504 ko04720 Long-term potentiation 14/340 99/7206 0.000204958054166 ko04713 Circadian entrainment 16/340 136/7206 0.0006295792038 ko00561 Glycerolipid metabolism 10/340 63/7206 0.00065496498779 ko05203 Viral carcinogenesis 3/340 277/7206 0.00127606860478 ko04970 Salivary secretion 12/340 95/7206 0.0015983875272 ko04726 Serotonergic synapse 15/340 137/7206 0.00192542280845 ko00564 Glycerophospholipid metabolism 12/340 99/7206 0.00228323732044 ko04146 Peroxisome 11/340 89/7206 0.00294682923057 ko04261 Adrenergic signaling in cardiomyocytes 19/340 205/7206 0.00410670828346 ko00680 Methane metabolism 6/340 34/7206 0.00462519651189 ko04022 cGMP-PKG signaling pathway 20/340 216/7206 0.00469580350944 ko04723 Retrograde endocannabinoid signaling 17/340 175/7206 0.00547054188223 ko05169 Epstein-Barr virus infection 2/340 206/7206 0.00652757372528 ko04810 Regulation of actin cytoskeleton 4/340 264/7206 0.00740291489175 ko04742 Taste transduction 8/340 61/7206 0.00747811327626 ko04745 Phototransduction - fly 6/340 38/7206 0.00810541059868 ko04060 Cytokine-cytokine receptor interaction 2/340 191/7206 0.00879890054417 ko05031 Amphetamine addiction 10/340 91/7206 0.0102678471329 ko05322 Systemic lupus erythematosus 1/340 151/7206 0.0103310869054 ko05160 Hepatitis C 1/340 153/7206 0.0105203744487 ko04730 Long-term depression 9/340 78/7206 0.0107424769673 ko04371 Apelin signaling pathway 16/340 177/7206 0.0109350645058 ko05168 Herpes simplex infection 2/340 182/7206 0.0124502202153 ko04930 Type II diabetes mellitus 7/340 54/7206 0.0128280762655 ko00051 Fructose and mannose metabolism 6/340 42/7206 0.0131574972191 ko04136 Autophagy - other 5/340 31/7206 0.0140219319116 ko04750 Inflammatory mediator regulation of TRP channels 12/340 122/7206 0.0148125939795 ko03040 Spliceosome 1/340 145/7206 0.0153096923292 ko05033 Nicotine addiction 7/340 56/7206 0.0155087844675 ko05224 Breast cancer 2/340 174/7206 0.0175940108207 ko04151 PI3K-Akt signaling pathway 9/340 390/7206 0.0188960696238 ko01200 Carbon metabolism 12/340 128/7206 0.0193019310166 ko04213 Longevity regulating pathway - multiple species 9/340 86/7206 0.0195309847963 ko00281 Geraniol degradation 2/340 5/7206 0.0201888913148 ko04711 Circadian rhythm - fly 3/340 13/7206 0.020922471787 ko04514 Cell adhesion molecules (CAMs) 12/340 130/7206 0.0211591959184 ko04550 Signaling pathways regulating pluripotency of stem cells 2/340 165/7206 0.0247417554569 ko05164 Influenza A 2/340 167/7206 0.0249178009033 ko04911 Insulin secretion 11/340 117/7206 0.0251439940444 ko04971 Gastric acid secretion 10/340 98/7206 0.0252460392216 ko00380 Tryptophan metabolism 6/340 50/7206 0.0291478641618 ko00362 Benzoate degradation 2/340 6/7206 0.029347361673 ko00650 Butanoate metabolism 4/340 26/7206 0.032006284392 ko03010 Ribosome 1/340 129/7206 0.0322525709702 ko04728 Dopaminergic synapse 15/340 185/7206 0.0344363425471 ko02010 ABC transporters 5/340 39/7206 0.0350225774249 ko04072 Phospholipase D signaling pathway 16/340 197/7206 0.0379476492858 ko04972 Pancreatic secretion 10/340 111/7206 0.040665541948 ko05162 Measles 1/340 120/7206 0.0460709205