ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	192/1112	423/7206	3.56696290356e-52
ko04724	Glutamatergic synapse	90/1112	152/7206	7.91064656604e-36
ko05033	Nicotine addiction	50/1112	56/7206	1.28973784852e-34
ko05032	Morphine addiction	68/1112	110/7206	7.15795571558e-29
ko04713	Circadian entrainment	75/1112	136/7206	3.42732226477e-27
ko04727	GABAergic synapse	66/1112	110/7206	5.82979177749e-27
ko04721	Synaptic vesicle cycle	52/1112	80/7206	7.99923494081e-24
ko04728	Dopaminergic synapse	85/1112	185/7206	1.88751858325e-23
ko04725	Cholinergic synapse	75/1112	160/7206	1.87463825331e-21
ko04723	Retrograde endocannabinoid signaling	78/1112	175/7206	1.38677260744e-20
ko04024	cAMP signaling pathway	98/1112	279/7206	1.41748838195e-16
ko04726	Serotonergic synapse	61/1112	137/7206	2.61059307194e-16
ko04911	Insulin secretion	54/1112	117/7206	2.12068404937e-15
ko04020	Calcium signaling pathway	90/1112	265/7206	2.5101961734e-14
ko04744	Phototransduction	26/1112	36/7206	3.25265447618e-14
ko04742	Taste transduction	35/1112	61/7206	5.00023988612e-14
ko04921	Oxytocin signaling pathway	76/1112	209/7206	5.38581621792e-14
ko05031	Amphetamine addiction	44/1112	91/7206	1.11273186981e-13
ko04720	Long-term potentiation	46/1112	99/7206	1.94129584931e-13
ko04261	Adrenergic signaling in cardiomyocytes	68/1112	205/7206	1.84094943202e-10
ko03040	Spliceosome	1/1112	145/7206	8.55151655548e-10
ko05030	Cocaine addiction	32/1112	73/7206	5.78344885479e-09
ko04925	Aldosterone synthesis and secretion	39/1112	105/7206	5.64959555808e-08
ko04970	Salivary secretion	36/1112	95/7206	6.7807811041e-08
ko04971	Gastric acid secretion	36/1112	98/7206	2.35117425481e-07
ko04740	Olfactory transduction	31/1112	80/7206	3.08569416818e-07
ko04621	NOD-like receptor signaling pathway	5/1112	157/7206	9.56009665143e-07
ko04060	Cytokine-cytokine receptor interaction	8/1112	191/7206	1.19276294697e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1112	74/7206	2.01461324818e-06
ko05203	Viral carcinogenesis	17/1112	277/7206	2.37525887665e-06
ko05168	Herpes simplex infection	8/1112	182/7206	3.40182312302e-06
ko03013	RNA transport	7/1112	166/7206	6.09779828975e-06
ko04966	Collecting duct acid secretion	14/1112	26/7206	6.22923184428e-06
ko04360	Axon guidance	62/1112	233/7206	7.69524716966e-06
ko04070	Phosphatidylinositol signaling system	36/1112	112/7206	7.98565509435e-06
ko04141	Protein processing in endoplasmic reticulum	9/1112	184/7206	1.05833623415e-05
ko05322	Systemic lupus erythematosus	6/1112	151/7206	1.08689646181e-05
ko04010	MAPK signaling pathway	79/1112	321/7206	1.17819305077e-05
ko04022	cGMP-PKG signaling pathway	58/1112	216/7206	1.30113028472e-05
ko04514	Cell adhesion molecules (CAMs)	39/1112	130/7206	2.17506693776e-05
ko04730	Long-term depression	27/1112	78/7206	2.28550376401e-05
ko05164	Influenza A	8/1112	167/7206	2.85790116779e-05
ko04072	Phospholipase D signaling pathway	53/1112	197/7206	3.25372824316e-05
ko04745	Phototransduction - fly	16/1112	38/7206	7.09650697123e-05
ko04110	Cell cycle	7/1112	145/7206	0.000101061598318
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1112	79/7206	0.00010476330699
ko05110	Vibrio cholerae infection	22/1112	63/7206	0.000127888722818
ko04972	Pancreatic secretion	33/1112	111/7206	0.000153926656745
ko04260	Cardiac muscle contraction	30/1112	98/7206	0.000179997561379
ko05169	Epstein-Barr virus infection	14/1112	206/7206	0.000184916461007
ko04540	Gap junction	36/1112	128/7206	0.000274136636554
ko04915	Estrogen signaling pathway	36/1112	131/7206	0.000340747327228
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1112	59/7206	0.00038103164195
ko04612	Antigen processing and presentation	2/1112	77/7206	0.00040334792104
ko04610	Complement and coagulation cascades	2/1112	79/7206	0.000416461223963
ko03008	Ribosome biogenesis in eukaryotes	2/1112	79/7206	0.000416461223963
ko04924	Renin secretion	26/1112	86/7206	0.000441991243341
ko04014	Ras signaling pathway	65/1112	279/7206	0.000486231263901
ko05162	Measles	6/1112	120/7206	0.000515617381048
ko04120	Ubiquitin mediated proteolysis	8/1112	138/7206	0.000756616367871
ko04750	Inflammatory mediator regulation of TRP channels	33/1112	122/7206	0.000875262859025
ko04064	NF-kappa B signaling pathway	4/1112	96/7206	0.000887918724197
ko05205	Proteoglycans in cancer	24/1112	271/7206	0.00146603814248
ko00240	Pyrimidine metabolism	6/1112	110/7206	0.00197506994539
ko00520	Amino sugar and nucleotide sugar metabolism	1/1112	55/7206	0.00210635029825
ko00480	Glutathione metabolism	1/1112	55/7206	0.00210635029825
ko05414	Dilated cardiomyopathy	30/1112	112/7206	0.00211058487319
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1112	14/7206	0.00258515212295
ko04626	Plant-pathogen interaction	8/1112	18/7206	0.00322595841546
ko05140	Leishmaniasis	3/1112	75/7206	0.0033137410703
ko04912	GnRH signaling pathway	31/1112	122/7206	0.00349638685773
ko04214	Apoptosis - fly	3/1112	72/7206	0.00472871418162
ko04976	Bile secretion	22/1112	80/7206	0.00475464975831
ko05161	Hepatitis B	14/1112	173/7206	0.00535475829942
ko04371	Apelin signaling pathway	41/1112	177/7206	0.00593022621082
ko03420	Nucleotide excision repair	1/1112	46/7206	0.00691299920212
ko04146	Peroxisome	5/1112	89/7206	0.00726223793615
ko05034	Alcoholism	52/1112	238/7206	0.0078730144552
ko05145	Toxoplasmosis	9/1112	126/7206	0.00839420038556
ko05321	Inflammatory bowel disease (IBD)	2/1112	56/7206	0.00863802964789
ko04964	Proximal tubule bicarbonate reclamation	10/1112	29/7206	0.00892916677996
ko04922	Glucagon signaling pathway	31/1112	128/7206	0.00897307696665
ko01524	Platinum drug resistance	4/1112	76/7206	0.0099967445752
ko04657	IL-17 signaling pathway	5/1112	87/7206	0.0102116618438
ko05418	Fluid shear stress and atherosclerosis	15/1112	173/7206	0.0103814307725
ko03022	Basal transcription factors	1/1112	44/7206	0.0104491428988
ko05144	Malaria	1/1112	45/7206	0.0109045171386
ko00071	Fatty acid degradation	1/1112	45/7206	0.0109045171386
ko00562	Inositol phosphate metabolism	23/1112	89/7206	0.0110868893558
ko04210	Apoptosis	16/1112	180/7206	0.0118950985189
ko04350	TGF-beta signaling pathway	7/1112	103/7206	0.012668505273
ko05166	HTLV-I infection	30/1112	292/7206	0.0128082470767
ko00310	Lysine degradation	4/1112	73/7206	0.01395183961
ko04217	Necroptosis	16/1112	178/7206	0.0152119210539
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1112	40/7206	0.0154210815103
ko00140	Steroid hormone biosynthesis	1/1112	41/7206	0.0154661920873
ko05231	Choline metabolism in cancer	31/1112	134/7206	0.0157663357908
ko04510	Focal adhesion	24/1112	240/7206	0.0177557952328
ko05222	Small cell lung cancer	6/1112	89/7206	0.0180130874395
ko04622	RIG-I-like receptor signaling pathway	3/1112	62/7206	0.0198774908245
ko04630	Jak-STAT signaling pathway	11/1112	132/7206	0.0204781434722
ko04930	Type II diabetes mellitus	15/1112	54/7206	0.0209113459109
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1112	182/7206	0.0216560511416
ko04062	Chemokine signaling pathway	43/1112	201/7206	0.0223361488344
ko04658	Th1 and Th2 cell differentiation	7/1112	96/7206	0.022623190664
ko00630	Glyoxylate and dicarboxylate metabolism	1/1112	38/7206	0.0229227224127
ko03410	Base excision repair	1/1112	38/7206	0.0229227224127
ko05202	Transcriptional misregulation in cancer	18/1112	188/7206	0.0239563679514
ko05133	Pertussis	6/1112	87/7206	0.0243645760958
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1112	100/7206	0.0245599775792
ko00260	Glycine, serine and threonine metabolism	2/1112	48/7206	0.026230698026
ko03320	PPAR signaling pathway	4/1112	69/7206	0.0276127590638
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1112	92/7206	0.028948158828
ko04973	Carbohydrate digestion and absorption	12/1112	42/7206	0.0290322853456
ko04668	TNF signaling pathway	10/1112	120/7206	0.0295829014933
ko04114	Oocyte meiosis	31/1112	139/7206	0.0318946908115
ko03018	RNA degradation	6/1112	84/7206	0.032753795092
ko00512	Mucin type O-glycan biosynthesis	9/1112	29/7206	0.0338677068651
ko00500	Starch and sucrose metabolism	1/1112	35/7206	0.0339936804331
ko05016	Huntington's disease	22/1112	215/7206	0.0344147935121
ko04115	p53 signaling pathway	5/1112	74/7206	0.0351406623987
ko00982	Drug metabolism - cytochrome P450	1/1112	37/7206	0.0358574902423
ko04923	Regulation of lipolysis in adipocytes	19/1112	77/7206	0.0371851887083
ko05214	Glioma	19/1112	79/7206	0.0408214052505
ko05131	Shigellosis	6/1112	82/7206	0.0441838360854
ko04722	Neurotrophin signaling pathway	34/1112	160/7206	0.04586063101