ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	213/1254	423/7206	2.40257711249e-58
ko04724	Glutamatergic synapse	98/1254	152/7206	6.69400451531e-39
ko05032	Morphine addiction	75/1254	110/7206	2.05025975176e-32
ko05033	Nicotine addiction	50/1254	56/7206	5.19841963673e-32
ko04713	Circadian entrainment	82/1254	136/7206	1.27274275536e-29
ko04727	GABAergic synapse	72/1254	110/7206	2.09089489454e-29
ko04728	Dopaminergic synapse	90/1254	185/7206	3.81590216911e-23
ko04725	Cholinergic synapse	81/1254	160/7206	2.39769472672e-22
ko04721	Synaptic vesicle cycle	52/1254	80/7206	2.49580582338e-21
ko04723	Retrograde endocannabinoid signaling	83/1254	175/7206	1.62374086054e-20
ko04020	Calcium signaling pathway	107/1254	265/7206	2.59830851189e-19
ko04726	Serotonergic synapse	68/1254	137/7206	2.4596007044e-18
ko04911	Insulin secretion	61/1254	117/7206	6.45091144728e-18
ko04024	cAMP signaling pathway	108/1254	279/7206	6.89065659717e-18
ko04921	Oxytocin signaling pathway	84/1254	209/7206	2.66485503107e-15
ko04742	Taste transduction	37/1254	61/7206	3.98854926201e-14
ko04744	Phototransduction	27/1254	36/7206	4.62684242974e-14
ko05031	Amphetamine addiction	47/1254	91/7206	6.87545436191e-14
ko04720	Long-term potentiation	49/1254	99/7206	1.69943723676e-13
ko04261	Adrenergic signaling in cardiomyocytes	76/1254	205/7206	8.35401438416e-12
ko04970	Salivary secretion	45/1254	95/7206	1.17595243642e-11
ko03040	Spliceosome	2/1254	145/7206	5.9122186822e-10
ko03010	Ribosome	1/1254	129/7206	9.59987128669e-10
ko04925	Aldosterone synthesis and secretion	44/1254	105/7206	4.31971482421e-09
ko04971	Gastric acid secretion	41/1254	98/7206	1.62838965463e-08
ko05030	Cocaine addiction	33/1254	73/7206	2.84880859926e-08
ko04070	Phosphatidylinositol signaling system	44/1254	112/7206	3.88736476222e-08
ko05203	Viral carcinogenesis	19/1254	277/7206	2.66400515151e-07
ko04360	Axon guidance	72/1254	233/7206	3.73859197352e-07
ko03013	RNA transport	7/1254	166/7206	3.84127216744e-07
ko05168	Herpes simplex infection	9/1254	182/7206	5.04523796297e-07
ko04740	Olfactory transduction	33/1254	80/7206	6.16159481837e-07
ko04022	cGMP-PKG signaling pathway	67/1254	216/7206	6.19205086503e-07
ko05322	Systemic lupus erythematosus	6/1254	151/7206	6.43723923161e-07
ko04060	Cytokine-cytokine receptor interaction	11/1254	191/7206	2.45283360312e-06
ko04730	Long-term depression	31/1254	78/7206	2.68390041475e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1254	74/7206	2.7795690892e-06
ko04540	Gap junction	44/1254	128/7206	2.80684160443e-06
ko04972	Pancreatic secretion	40/1254	111/7206	2.98604035775e-06
ko04010	MAPK signaling pathway	88/1254	321/7206	5.20605359896e-06
ko05164	Influenza A	9/1254	167/7206	6.32044525355e-06
ko04141	Protein processing in endoplasmic reticulum	11/1254	184/7206	6.87925395675e-06
ko04612	Antigen processing and presentation	1/1254	77/7206	1.20445411017e-05
ko04745	Phototransduction - fly	18/1254	38/7206	1.88816711238e-05
ko04621	NOD-like receptor signaling pathway	9/1254	157/7206	2.49301589233e-05
ko04966	Collecting duct acid secretion	14/1254	26/7206	2.6132144643e-05
ko04514	Cell adhesion molecules (CAMs)	42/1254	130/7206	3.17842386598e-05
ko04110	Cell cycle	8/1254	145/7206	3.22997869375e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1254	79/7206	3.48103124147e-05
ko05414	Dilated cardiomyopathy	37/1254	112/7206	4.6195554119e-05
ko04072	Phospholipase D signaling pathway	57/1254	197/7206	5.2301658045e-05
ko04610	Complement and coagulation cascades	2/1254	79/7206	7.01355025717e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1254	79/7206	7.01355025717e-05
ko05110	Vibrio cholerae infection	24/1254	63/7206	7.85763035986e-05
ko05169	Epstein-Barr virus infection	16/1254	206/7206	7.87230281855e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1254	59/7206	7.96091488954e-05
ko04750	Inflammatory mediator regulation of TRP channels	38/1254	122/7206	0.000161417202118
ko05162	Measles	7/1254	120/7206	0.00023814054427
ko04924	Renin secretion	29/1254	86/7206	0.000253532520031
ko04923	Regulation of lipolysis in adipocytes	26/1254	77/7206	0.000423241412795
ko04014	Ras signaling pathway	71/1254	279/7206	0.000514423133775
ko00520	Amino sugar and nucleotide sugar metabolism	1/1254	55/7206	0.00052579736248
ko04260	Cardiac muscle contraction	31/1254	98/7206	0.000643902093865
ko04976	Bile secretion	26/1254	80/7206	0.000914336245699
ko04915	Estrogen signaling pathway	38/1254	131/7206	0.000989544088569
ko04912	GnRH signaling pathway	36/1254	122/7206	0.000990930484696
ko00590	Arachidonic acid metabolism	1/1254	52/7206	0.00130171746542
ko04918	Thyroid hormone synthesis	27/1254	86/7206	0.00139900031525
ko04120	Ubiquitin mediated proteolysis	11/1254	138/7206	0.00204180271513
ko05205	Proteoglycans in cancer	29/1254	271/7206	0.00241293548967
ko04371	Apelin signaling pathway	47/1254	177/7206	0.00241825444364
ko04064	NF-kappa B signaling pathway	6/1254	96/7206	0.00251564350091
ko05144	Malaria	1/1254	45/7206	0.00278377606753
ko03420	Nucleotide excision repair	1/1254	46/7206	0.00278689311979
ko05140	Leishmaniasis	4/1254	75/7206	0.00324145821091
ko00480	Glutathione metabolism	2/1254	55/7206	0.00368934580732
ko03022	Basal transcription factors	1/1254	44/7206	0.00425865911544
ko05166	HTLV-I infection	33/1254	292/7206	0.00442011845919
ko04922	Glucagon signaling pathway	35/1254	128/7206	0.00449545848597
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1254	14/7206	0.00523281744596
ko05161	Hepatitis B	17/1254	173/7206	0.00600132174908
ko04622	RIG-I-like receptor signaling pathway	3/1254	62/7206	0.00625233324945
ko04658	Th1 and Th2 cell differentiation	7/1254	96/7206	0.00630023741279
ko04657	IL-17 signaling pathway	6/1254	87/7206	0.00650891633487
ko05133	Pertussis	6/1254	87/7206	0.00650891633487
ko04626	Plant-pathogen interaction	8/1254	18/7206	0.00692650991565
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1254	100/7206	0.00751510519981
ko00240	Pyrimidine metabolism	9/1254	110/7206	0.007543048788
ko05145	Toxoplasmosis	11/1254	126/7206	0.0086086306225
ko03018	RNA degradation	6/1254	84/7206	0.00896783401569
ko04630	Jak-STAT signaling pathway	12/1254	132/7206	0.0102762942403
ko04964	Proximal tubule bicarbonate reclamation	11/1254	29/7206	0.0107719724788
ko00562	Inositol phosphate metabolism	25/1254	89/7206	0.0108769970578
ko04973	Carbohydrate digestion and absorption	14/1254	42/7206	0.0122819035336
ko05131	Shigellosis	6/1254	82/7206	0.0122838699128
ko05321	Inflammatory bowel disease (IBD)	3/1254	56/7206	0.0126118457786
ko04115	p53 signaling pathway	5/1254	74/7206	0.0128255685418
ko04710	Circadian rhythm	14/1254	43/7206	0.0140813193473
ko04146	Peroxisome	7/1254	89/7206	0.0158906394171
ko05215	Prostate cancer	10/1254	111/7206	0.0161966091808
ko00071	Fatty acid degradation	2/1254	45/7206	0.0169046641139
ko04350	TGF-beta signaling pathway	9/1254	103/7206	0.0178562948569
ko04214	Apoptosis - fly	5/1254	72/7206	0.0178899092727
ko04062	Chemokine signaling pathway	48/1254	201/7206	0.0179803996693
ko04330	Notch signaling pathway	4/1254	62/7206	0.0180970658659
ko05231	Choline metabolism in cancer	34/1254	134/7206	0.020663071464
ko00860	Porphyrin and chlorophyll metabolism	1/1254	34/7206	0.0214945390595
ko04960	Aldosterone-regulated sodium reabsorption	13/1254	41/7206	0.0220115985896
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1254	182/7206	0.0221971186224
ko05016	Huntington's disease	25/1254	215/7206	0.0222300861843
ko04270	Vascular smooth muscle contraction	38/1254	154/7206	0.0233498955242
ko04620	Toll-like receptor signaling pathway	9/1254	100/7206	0.0235235169432
ko04015	Rap1 signaling pathway	63/1254	278/7206	0.023528342634
ko03320	PPAR signaling pathway	5/1254	69/7206	0.0243609285436
ko05418	Fluid shear stress and atherosclerosis	19/1254	173/7206	0.0250062330744
ko04916	Melanogenesis	35/1254	142/7206	0.0252380002763
ko04217	Necroptosis	20/1254	178/7206	0.0273468582533
ko04930	Type II diabetes mellitus	16/1254	54/7206	0.0283227332538
ko04510	Focal adhesion	29/1254	240/7206	0.0299307109832
ko05132	Salmonella infection	9/1254	98/7206	0.0310217608411
ko04114	Oocyte meiosis	34/1254	139/7206	0.0315341325836
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1254	15/7206	0.033143641939
ko05222	Small cell lung cancer	8/1254	89/7206	0.0342974058361
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1254	40/7206	0.0355442980558
ko05214	Glioma	21/1254	79/7206	0.0363654009959
ko05202	Transcriptional misregulation in cancer	22/1254	188/7206	0.0400661180497
ko00310	Lysine degradation	6/1254	73/7206	0.0420650957899
ko00600	Sphingolipid metabolism	5/1254	63/7206	0.0451399895992
ko04640	Hematopoietic cell lineage	5/1254	64/7206	0.0454218573175
ko04210	Apoptosis	21/1254	180/7206	0.0457259374039
ko05320	Autoimmune thyroid disease	1/1254	29/7206	0.0478673092215