ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	190/1070	423/7206	1.6121087979e-53
ko04724	Glutamatergic synapse	88/1070	152/7206	2.48795915176e-35
ko05033	Nicotine addiction	48/1070	56/7206	2.97378145729e-32
ko04713	Circadian entrainment	75/1070	136/7206	2.60568905327e-28
ko04727	GABAergic synapse	64/1070	110/7206	4.38856471232e-26
ko05032	Morphine addiction	64/1070	110/7206	4.38856471232e-26
ko04728	Dopaminergic synapse	83/1070	185/7206	3.24555234718e-23
ko04721	Synaptic vesicle cycle	50/1070	80/7206	1.37437238384e-22
ko04725	Cholinergic synapse	75/1070	160/7206	1.67788006413e-22
ko04723	Retrograde endocannabinoid signaling	76/1070	175/7206	2.75612841821e-20
ko04024	cAMP signaling pathway	98/1070	279/7206	6.94279062654e-18
ko04742	Taste transduction	37/1070	61/7206	2.07665903652e-16
ko04911	Insulin secretion	54/1070	117/7206	3.84424111885e-16
ko04726	Serotonergic synapse	59/1070	137/7206	8.66907254379e-16
ko04020	Calcium signaling pathway	90/1070	265/7206	1.86913701269e-15
ko04921	Oxytocin signaling pathway	76/1070	209/7206	6.23580053732e-15
ko04720	Long-term potentiation	46/1070	99/7206	4.53469791928e-14
ko05031	Amphetamine addiction	42/1070	91/7206	7.79114092617e-13
ko04261	Adrenergic signaling in cardiomyocytes	69/1070	205/7206	8.44128634713e-12
ko04740	Olfactory transduction	37/1070	80/7206	1.70039033271e-11
ko04970	Salivary secretion	40/1070	95/7206	9.58435537003e-11
ko04360	Axon guidance	71/1070	233/7206	7.7634971398e-10
ko04744	Phototransduction	21/1070	36/7206	2.00453126438e-09
ko03040	Spliceosome	1/1070	145/7206	3.72414353271e-09
ko04925	Aldosterone synthesis and secretion	39/1070	105/7206	1.23367394983e-08
ko04971	Gastric acid secretion	37/1070	98/7206	1.75635245001e-08
ko05030	Cocaine addiction	30/1070	73/7206	4.22891769465e-08
ko05203	Viral carcinogenesis	13/1070	277/7206	6.2144807022e-08
ko05168	Herpes simplex infection	5/1070	182/7206	7.11517077608e-08
ko05164	Influenza A	5/1070	167/7206	7.24370217226e-07
ko04060	Cytokine-cytokine receptor interaction	7/1070	191/7206	7.72599729242e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1070	74/7206	9.13012093575e-07
ko04010	MAPK signaling pathway	80/1070	321/7206	1.16845035792e-06
ko04540	Gap junction	40/1070	128/7206	1.93987264389e-06
ko04730	Long-term depression	28/1070	78/7206	3.10273022535e-06
ko05322	Systemic lupus erythematosus	5/1070	151/7206	4.59988051599e-06
ko04120	Ubiquitin mediated proteolysis	4/1070	138/7206	5.19460829639e-06
ko04022	cGMP-PKG signaling pathway	57/1070	216/7206	9.24025160479e-06
ko04745	Phototransduction - fly	17/1070	38/7206	9.52353753129e-06
ko04924	Renin secretion	29/1070	86/7206	9.57200475507e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1070	79/7206	1.61366528294e-05
ko04972	Pancreatic secretion	34/1070	111/7206	1.93798118302e-05
ko03013	RNA transport	7/1070	166/7206	1.96009560652e-05
ko04966	Collecting duct acid secretion	13/1070	26/7206	2.49822547523e-05
ko04514	Cell adhesion molecules (CAMs)	38/1070	130/7206	2.66726089766e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1070	59/7206	6.0799171908e-05
ko05169	Epstein-Barr virus infection	12/1070	206/7206	6.08107789572e-05
ko04260	Cardiac muscle contraction	30/1070	98/7206	7.22810661916e-05
ko04141	Protein processing in endoplasmic reticulum	10/1070	184/7206	8.44193754044e-05
ko05110	Vibrio cholerae infection	22/1070	63/7206	9.52133244175e-05
ko04612	Antigen processing and presentation	1/1070	77/7206	0.000130336022904
ko05414	Dilated cardiomyopathy	32/1070	112/7206	0.000146332648306
ko04621	NOD-like receptor signaling pathway	8/1070	157/7206	0.000153986022578
ko04750	Inflammatory mediator regulation of TRP channels	34/1070	122/7206	0.000162335160582
ko04072	Phospholipase D signaling pathway	49/1070	197/7206	0.00021755555407
ko05162	Measles	5/1070	120/7206	0.000248014370829
ko04014	Ras signaling pathway	64/1070	279/7206	0.000280032021796
ko04070	Phosphatidylinositol signaling system	31/1070	112/7206	0.000400462523577
ko04110	Cell cycle	8/1070	145/7206	0.000566066971879
ko03008	Ribosome biogenesis in eukaryotes	2/1070	79/7206	0.000632851695991
ko05205	Proteoglycans in cancer	22/1070	271/7206	0.000890985711845
ko05140	Leishmaniasis	2/1070	75/7206	0.000908864379886
ko00240	Pyrimidine metabolism	5/1070	110/7206	0.00100737528436
ko04976	Bile secretion	23/1070	80/7206	0.00126649040169
ko04064	NF-kappa B signaling pathway	4/1070	96/7206	0.00129627483971
ko04915	Estrogen signaling pathway	33/1070	131/7206	0.00172718555399
ko04964	Proximal tubule bicarbonate reclamation	11/1070	29/7206	0.00193600180537
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1070	182/7206	0.00204197848309
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1070	14/7206	0.00205437926745
ko05161	Hepatitis B	12/1070	173/7206	0.00223762259587
ko04371	Apelin signaling pathway	41/1070	177/7206	0.00264189200195
ko00480	Glutathione metabolism	1/1070	55/7206	0.00336017905774
ko04146	Peroxisome	4/1070	89/7206	0.00380514993551
ko04640	Hematopoietic cell lineage	2/1070	64/7206	0.00418764831016
ko04912	GnRH signaling pathway	30/1070	122/7206	0.00432535603092
ko00590	Arachidonic acid metabolism	1/1070	52/7206	0.00495472501467
ko05166	HTLV-I infection	27/1070	292/7206	0.0053715550041
ko00330	Arginine and proline metabolism	2/1070	61/7206	0.00609366357054
ko00260	Glycine, serine and threonine metabolism	1/1070	48/7206	0.00711143921485
ko04916	Melanogenesis	33/1070	142/7206	0.00817812998712
ko05418	Fluid shear stress and atherosclerosis	14/1070	173/7206	0.00916909217204
ko05144	Malaria	1/1070	45/7206	0.0105751622721
ko00071	Fatty acid degradation	1/1070	45/7206	0.0105751622721
ko00620	Pyruvate metabolism	1/1070	46/7206	0.0107987303644
ko03420	Nucleotide excision repair	1/1070	46/7206	0.0107987303644
ko04626	Plant-pathogen interaction	7/1070	18/7206	0.011091114018
ko04930	Type II diabetes mellitus	15/1070	54/7206	0.0118064929556
ko05321	Inflammatory bowel disease (IBD)	2/1070	56/7206	0.0129193677206
ko04657	IL-17 signaling pathway	5/1070	87/7206	0.0142270150564
ko01524	Platinum drug resistance	4/1070	76/7206	0.0142704270515
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1070	100/7206	0.0150931261925
ko04015	Rap1 signaling pathway	56/1070	278/7206	0.015655247169
ko03022	Basal transcription factors	1/1070	44/7206	0.0166150926151
ko04350	TGF-beta signaling pathway	7/1070	103/7206	0.0172434520463
ko04140	Autophagy - animal	14/1070	164/7206	0.0193545685039
ko04668	TNF signaling pathway	9/1070	120/7206	0.0194495614781
ko03018	RNA degradation	5/1070	84/7206	0.0194649609938
ko04210	Apoptosis	16/1070	180/7206	0.0195549541203
ko00310	Lysine degradation	4/1070	73/7206	0.0198167886706
ko04923	Regulation of lipolysis in adipocytes	19/1070	77/7206	0.0225739165096
ko04620	Toll-like receptor signaling pathway	7/1070	100/7206	0.0230505463067
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1070	40/7206	0.0235566021064
ko00562	Inositol phosphate metabolism	21/1070	89/7206	0.0243121154246
ko04217	Necroptosis	16/1070	178/7206	0.0246502284912
ko05034	Alcoholism	48/1070	238/7206	0.0255540270857
ko05131	Shigellosis	5/1070	82/7206	0.0270737471872
ko04214	Apoptosis - fly	4/1070	72/7206	0.0283583531165
ko04330	Notch signaling pathway	3/1070	62/7206	0.0289555173018
ko04622	RIG-I-like receptor signaling pathway	3/1070	62/7206	0.0289555173018
ko05145	Toxoplasmosis	10/1070	126/7206	0.030543199745
ko05016	Huntington's disease	21/1070	215/7206	0.0320366808825
ko05133	Pertussis	6/1070	87/7206	0.0332882546128
ko00982	Drug metabolism - cytochrome P450	1/1070	37/7206	0.0347676399995
ko04630	Jak-STAT signaling pathway	11/1070	132/7206	0.0348649653303
ko03410	Base excision repair	1/1070	38/7206	0.0357543899241
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/1070	92/7206	0.0379135593717
ko00270	Cysteine and methionine metabolism	2/1070	47/7206	0.0383388859215
ko04658	Th1 and Th2 cell differentiation	7/1070	96/7206	0.041443992523
ko04722	Neurotrophin signaling pathway	33/1070	160/7206	0.0427596324875
ko05215	Prostate cancer	9/1070	111/7206	0.0433102840338
ko04062	Chemokine signaling pathway	40/1070	201/7206	0.0443385156786
ko01200	Carbon metabolism	11/1070	128/7206	0.0444407110396
ko04115	p53 signaling pathway	5/1070	74/7206	0.0483002061134
ko04973	Carbohydrate digestion and absorption	11/1070	42/7206	0.0483355571512