ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	195/1091	423/7206	8.40509772074e-56
ko04724	Glutamatergic synapse	85/1091	152/7206	6.02219801078e-32
ko05033	Nicotine addiction	48/1091	56/7206	7.51497660051e-32
ko05032	Morphine addiction	67/1091	110/7206	2.04071285557e-28
ko04727	GABAergic synapse	64/1091	110/7206	1.35390592432e-25
ko04713	Circadian entrainment	71/1091	136/7206	2.19208175119e-24
ko04728	Dopaminergic synapse	83/1091	185/7206	1.22863882168e-22
ko04721	Synaptic vesicle cycle	50/1091	80/7206	3.36032607895e-22
ko04725	Cholinergic synapse	74/1091	160/7206	2.96287248445e-21
ko04723	Retrograde endocannabinoid signaling	77/1091	175/7206	1.96261904829e-20
ko04024	cAMP signaling pathway	99/1091	279/7206	7.81197248283e-18
ko04742	Taste transduction	38/1091	61/7206	4.31931618321e-17
ko04911	Insulin secretion	54/1091	117/7206	9.12764479967e-16
ko04726	Serotonergic synapse	59/1091	137/7206	2.16703832593e-15
ko04020	Calcium signaling pathway	89/1091	265/7206	1.8945833156e-14
ko04921	Oxytocin signaling pathway	74/1091	209/7206	1.83519137453e-13
ko04744	Phototransduction	25/1091	36/7206	2.78298175194e-13
ko04261	Adrenergic signaling in cardiomyocytes	70/1091	205/7206	6.33124081904e-12
ko04720	Long-term potentiation	43/1091	99/7206	1.03827496444e-11
ko05031	Amphetamine addiction	40/1091	91/7206	3.50347416125e-11
ko04740	Olfactory transduction	36/1091	80/7206	1.50165134734e-10
ko04970	Salivary secretion	40/1091	95/7206	1.76265667268e-10
ko03040	Spliceosome	1/1091	145/7206	2.31713764692e-09
ko05030	Cocaine addiction	31/1091	73/7206	1.58102286449e-08
ko04971	Gastric acid secretion	36/1091	98/7206	1.03902390997e-07
ko05203	Viral carcinogenesis	14/1091	277/7206	1.2537072311e-07
ko04360	Axon guidance	66/1091	233/7206	1.9780237156e-07
ko04925	Aldosterone synthesis and secretion	37/1091	105/7206	2.66400124525e-07
ko05168	Herpes simplex infection	6/1091	182/7206	2.84742116224e-07
ko04120	Ubiquitin mediated proteolysis	3/1091	138/7206	5.03999807982e-07
ko04022	cGMP-PKG signaling pathway	60/1091	216/7206	1.5848516396e-06
ko04060	Cytokine-cytokine receptor interaction	8/1091	191/7206	1.73185618703e-06
ko05322	Systemic lupus erythematosus	5/1091	151/7206	3.06466453652e-06
ko04010	MAPK signaling pathway	80/1091	321/7206	3.06732024578e-06
ko04514	Cell adhesion molecules (CAMs)	40/1091	130/7206	5.32034165699e-06
ko03013	RNA transport	7/1091	166/7206	8.97889004529e-06
ko05164	Influenza A	7/1091	167/7206	9.0154998538e-06
ko04730	Long-term depression	27/1091	78/7206	1.72088820329e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1091	74/7206	2.04953261064e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1091	79/7206	2.12737732367e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1091	59/7206	2.40449599399e-05
ko04540	Gap junction	38/1091	128/7206	2.69814190007e-05
ko04966	Collecting duct acid secretion	13/1091	26/7206	3.09339558421e-05
ko04972	Pancreatic secretion	34/1091	111/7206	4.06887944783e-05
ko04260	Cardiac muscle contraction	31/1091	98/7206	4.35497663588e-05
ko04924	Renin secretion	28/1091	86/7206	4.83956389493e-05
ko04141	Protein processing in endoplasmic reticulum	10/1091	184/7206	6.05544092824e-05
ko05110	Vibrio cholerae infection	22/1091	63/7206	0.000107776499167
ko04621	NOD-like receptor signaling pathway	8/1091	157/7206	0.00010810108774
ko04745	Phototransduction - fly	15/1091	38/7206	0.000227386683399
ko05162	Measles	5/1091	120/7206	0.000252720356373
ko05414	Dilated cardiomyopathy	32/1091	112/7206	0.000257467119569
ko04072	Phospholipase D signaling pathway	49/1091	197/7206	0.000263564528861
ko04750	Inflammatory mediator regulation of TRP channels	34/1091	122/7206	0.000286129944166
ko05169	Epstein-Barr virus infection	14/1091	206/7206	0.000341718113206
ko04110	Cell cycle	8/1091	145/7206	0.000402440756098
ko04610	Complement and coagulation cascades	2/1091	79/7206	0.000410319286428
ko03008	Ribosome biogenesis in eukaryotes	2/1091	79/7206	0.000410319286428
ko04014	Ras signaling pathway	64/1091	279/7206	0.000443056049748
ko04612	Antigen processing and presentation	2/1091	77/7206	0.000611022126047
ko04070	Phosphatidylinositol signaling system	31/1091	112/7206	0.000732721333077
ko04976	Bile secretion	24/1091	80/7206	0.000741816500725
ko05140	Leishmaniasis	2/1091	75/7206	0.000922311370132
ko04915	Estrogen signaling pathway	34/1091	131/7206	0.00120863986781
ko04371	Apelin signaling pathway	43/1091	177/7206	0.00130883793767
ko05205	Proteoglycans in cancer	23/1091	271/7206	0.00131036939406
ko04064	NF-kappa B signaling pathway	4/1091	96/7206	0.00133238455538
ko00480	Glutathione metabolism	1/1091	55/7206	0.00208891958471
ko04146	Peroxisome	4/1091	89/7206	0.00258133892804
ko00240	Pyrimidine metabolism	6/1091	110/7206	0.00282513561416
ko00590	Arachidonic acid metabolism	1/1091	52/7206	0.00312909690987
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1091	182/7206	0.00318603719113
ko04217	Necroptosis	14/1091	178/7206	0.00415554844846
ko04640	Hematopoietic cell lineage	2/1091	64/7206	0.00424845530244
ko00330	Arginine and proline metabolism	2/1091	61/7206	0.00613876040086
ko05418	Fluid shear stress and atherosclerosis	14/1091	173/7206	0.00701991082177
ko05161	Hepatitis B	14/1091	173/7206	0.00701991082177
ko00260	Glycine, serine and threonine metabolism	1/1091	48/7206	0.00719744362321
ko04964	Proximal tubule bicarbonate reclamation	10/1091	29/7206	0.00780260072111
ko05145	Toxoplasmosis	9/1091	126/7206	0.00831304082116
ko04657	IL-17 signaling pathway	5/1091	87/7206	0.0101028345788
ko03022	Basal transcription factors	1/1091	44/7206	0.0104430804147
ko04912	GnRH signaling pathway	29/1091	122/7206	0.0104871351979
ko05144	Malaria	1/1091	45/7206	0.0106264706608
ko00071	Fatty acid degradation	1/1091	45/7206	0.0106264706608
ko03420	Nucleotide excision repair	1/1091	46/7206	0.011126315727
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1091	14/7206	0.0119786419684
ko05321	Inflammatory bowel disease (IBD)	2/1091	56/7206	0.0131907004863
ko04658	Th1 and Th2 cell differentiation	6/1091	96/7206	0.0137779725424
ko03018	RNA degradation	5/1091	84/7206	0.0139137653851
ko01524	Platinum drug resistance	4/1091	76/7206	0.0144921237655
ko04140	Autophagy - animal	14/1091	164/7206	0.0150023508362
ko00140	Steroid hormone biosynthesis	1/1091	41/7206	0.0155581633814
ko05166	HTLV-I infection	30/1091	292/7206	0.0156455806198
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1091	100/7206	0.0167300750088
ko05131	Shigellosis	5/1091	82/7206	0.0191693249697
ko04330	Notch signaling pathway	3/1091	62/7206	0.0195623835996
ko04622	RIG-I-like receptor signaling pathway	3/1091	62/7206	0.0195623835996
ko04214	Apoptosis - fly	4/1091	72/7206	0.0196807089691
ko00310	Lysine degradation	4/1091	73/7206	0.0200472661019
ko04015	Rap1 signaling pathway	56/1091	278/7206	0.021026446849
ko04620	Toll-like receptor signaling pathway	7/1091	100/7206	0.0233447220399
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1091	40/7206	0.0239099316363
ko04923	Regulation of lipolysis in adipocytes	19/1091	77/7206	0.0246703565377
ko04630	Jak-STAT signaling pathway	11/1091	132/7206	0.0267814659833
ko04916	Melanogenesis	31/1091	142/7206	0.032427542997
ko05133	Pertussis	6/1091	87/7206	0.0335793078132
ko05034	Alcoholism	48/1091	238/7206	0.033941498621
ko04210	Apoptosis	17/1091	180/7206	0.0344071288706
ko01200	Carbon metabolism	11/1091	128/7206	0.0344211504986
ko04930	Type II diabetes mellitus	14/1091	54/7206	0.0347584716219
ko00982	Drug metabolism - cytochrome P450	1/1091	37/7206	0.0350930853561
ko04350	TGF-beta signaling pathway	8/1091	103/7206	0.0367765489128
ko00620	Pyruvate metabolism	2/1091	46/7206	0.0379990530205
ko00270	Cysteine and methionine metabolism	2/1091	47/7206	0.0385747673116
ko04668	TNF signaling pathway	10/1091	120/7206	0.0388204867526
ko04270	Vascular smooth muscle contraction	33/1091	154/7206	0.0398007864595
ko04626	Plant-pathogen interaction	6/1091	18/7206	0.0433972872664
ko05215	Prostate cancer	9/1091	111/7206	0.0438695920044
ko04071	Sphingolipid signaling pathway	34/1091	162/7206	0.0450921538396
ko04062	Chemokine signaling pathway	41/1091	201/7206	0.0451427162711
ko04918	Thyroid hormone synthesis	20/1091	86/7206	0.0472867302955
ko04115	p53 signaling pathway	5/1091	74/7206	0.0485582003981