ko pathway ratio_in_study ratio_in_pop p_value ko04621 NOD-like receptor signaling pathway 34/245 157/7206 1.03738525565e-18 ko05164 Influenza A 30/245 167/7206 2.86322172754e-14 ko04380 Osteoclast differentiation 27/245 134/7206 3.24252883546e-14 ko04064 NF-kappa B signaling pathway 23/245 96/7206 5.67432425616e-14 ko04060 Cytokine-cytokine receptor interaction 30/245 191/7206 1.13542884102e-12 ko05162 Measles 23/245 120/7206 8.60463855356e-12 ko04217 Necroptosis 27/245 178/7206 3.84099884772e-11 ko04668 TNF signaling pathway 22/245 120/7206 6.27043109527e-11 ko05168 Herpes simplex infection 26/245 182/7206 3.53775682138e-10 ko04620 Toll-like receptor signaling pathway 19/245 100/7206 7.07822403065e-10 ko04622 RIG-I-like receptor signaling pathway 15/245 62/7206 1.36701471346e-09 ko04658 Th1 and Th2 cell differentiation 18/245 96/7206 2.53113999074e-09 ko05161 Hepatitis B 24/245 173/7206 3.22331704431e-09 ko04623 Cytosolic DNA-sensing pathway 12/245 41/7206 6.00323289319e-09 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/245 191/7206 2.36784806877e-08 ko05321 Inflammatory bowel disease (IBD) 13/245 56/7206 3.03539377339e-08 ko05160 Hepatitis C 21/245 153/7206 3.95458989501e-08 ko04659 Th17 cell differentiation 17/245 106/7206 8.13336922627e-08 ko04660 T cell receptor signaling pathway 18/245 124/7206 1.61831400726e-07 ko05145 Toxoplasmosis 18/245 126/7206 2.07524006735e-07 ko05340 Primary immunodeficiency 9/245 30/7206 4.0153743504e-07 ko04210 Apoptosis 21/245 180/7206 6.60384912259e-07 ko05140 Leishmaniasis 13/245 75/7206 1.14267642221e-06 ko05152 Tuberculosis 21/245 187/7206 1.24632597556e-06 ko04672 Intestinal immune network for IgA production 9/245 37/7206 2.83387252518e-06 ko04630 Jak-STAT signaling pathway 16/245 132/7206 9.05418679682e-06 ko05330 Allograft rejection 7/245 24/7206 1.0165610831e-05 ko05150 Staphylococcus aureus infection 8/245 36/7206 2.11016715348e-05 ko04650 Natural killer cell mediated cytotoxicity 13/245 97/7206 2.16084697658e-05 ko04662 B cell receptor signaling pathway 12/245 88/7206 3.77042167242e-05 ko05320 Autoimmune thyroid disease 7/245 29/7206 3.9626662829e-05 ko04612 Antigen processing and presentation 11/245 77/7206 5.14155644691e-05 ko05169 Epstein-Barr virus infection 19/245 206/7206 6.79236169967e-05 ko05166 HTLV-I infection 23/245 292/7206 0.000170478559506 ko04933 AGE-RAGE signaling pathway in diabetic complications 14/245 135/7206 0.000184820962987 ko05323 Rheumatoid arthritis 11/245 89/7206 0.000196088213134 ko05332 Graft-versus-host disease 5/245 18/7206 0.000259820661821 ko05131 Shigellosis 10/245 82/7206 0.000426495321942 ko04062 Chemokine signaling pathway 17/245 201/7206 0.000462138742337 ko04940 Type I diabetes mellitus 6/245 32/7206 0.000625716984316 ko04657 IL-17 signaling pathway 10/245 87/7206 0.000687427756345 ko05133 Pertussis 10/245 87/7206 0.000687427756345 ko04610 Complement and coagulation cascades 9/245 79/7206 0.00135099008865 ko05142 Chagas disease (American trypanosomiasis) 12/245 130/7206 0.00149747675018 ko05310 Asthma 4/245 17/7206 0.00218738176229 ko05416 Viral myocarditis 7/245 55/7206 0.00242759782955 ko05134 Legionellosis 8/245 74/7206 0.00345514095912 ko05144 Malaria 6/245 45/7206 0.00389040956663 ko05202 Transcriptional misregulation in cancer 14/245 188/7206 0.00608895881581 ko05212 Pancreatic cancer 8/245 83/7206 0.00696500783835 ko04917 Prolactin signaling pathway 8/245 87/7206 0.00919128774813 ko04920 Adipocytokine signaling pathway 8/245 89/7206 0.0104855612803 ko05215 Prostate cancer 9/245 111/7206 0.0129964342726 ko05203 Viral carcinogenesis 17/245 277/7206 0.0166436725495 ko05132 Salmonella infection 8/245 98/7206 0.0180290969295 ko05146 Amoebiasis 8/245 99/7206 0.0190586103603 ko05221 Acute myeloid leukemia 6/245 63/7206 0.019586394283 ko04728 Dopaminergic synapse 1/245 185/7206 0.0219365479636 ko04624 Toll and Imd signaling pathway 5/245 49/7206 0.0246197028511 ko05220 Chronic myeloid leukemia 7/245 85/7206 0.0250924383643 ko04145 Phagosome 11/245 162/7206 0.0253726541693 ko04611 Platelet activation 11/245 163/7206 0.0261576316991 ko05034 Alcoholism 2/245 238/7206 0.0262662577315 ko04068 FoxO signaling pathway 11/245 167/7206 0.0296131679898 ko05016 Huntington's disease 2/245 215/7206 0.0351288799957 ko03050 Proteasome 5/245 54/7206 0.0356591007975 ko05120 Epithelial cell signaling in Helicobacter pylori infection 7/245 92/7206 0.0365561227453 ko04670 Leukocyte transendothelial migration 10/245 151/7206 0.0378155652311 ko05010 Alzheimer's disease 2/245 202/7206 0.0490924828768