ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	198/1227	423/7206	3.18843262373e-49
ko04724	Glutamatergic synapse	90/1227	152/7206	2.46241052162e-32
ko05032	Morphine addiction	71/1227	110/7206	4.70127952132e-29
ko05033	Nicotine addiction	47/1227	56/7206	5.40901094678e-28
ko04727	GABAergic synapse	67/1227	110/7206	2.60800406107e-25
ko04713	Circadian entrainment	76/1227	136/7206	3.46617623564e-25
ko04725	Cholinergic synapse	79/1227	160/7206	1.47636943374e-21
ko04721	Synaptic vesicle cycle	51/1227	80/7206	8.12220531321e-21
ko04728	Dopaminergic synapse	85/1227	185/7206	1.68402883481e-20
ko04723	Retrograde endocannabinoid signaling	80/1227	175/7206	3.46996395013e-19
ko04024	cAMP signaling pathway	107/1227	279/7206	3.66824218075e-18
ko04020	Calcium signaling pathway	98/1227	265/7206	2.22237753467e-15
ko04911	Insulin secretion	56/1227	117/7206	7.36946388841e-15
ko04742	Taste transduction	37/1227	61/7206	1.95642141877e-14
ko04726	Serotonergic synapse	61/1227	137/7206	2.99189201449e-14
ko04921	Oxytocin signaling pathway	79/1227	209/7206	3.5758051298e-13
ko04744	Phototransduction	26/1227	36/7206	3.60238434507e-13
ko03040	Spliceosome	1/1227	145/7206	7.11046675844e-11
ko04261	Adrenergic signaling in cardiomyocytes	73/1227	205/7206	7.91909726363e-11
ko05031	Amphetamine addiction	41/1227	91/7206	3.37917222802e-10
ko04720	Long-term potentiation	43/1227	99/7206	5.25317523714e-10
ko03010	Ribosome	1/1227	129/7206	1.55310512003e-09
ko04970	Salivary secretion	41/1227	95/7206	1.68118663504e-09
ko04925	Aldosterone synthesis and secretion	41/1227	105/7206	5.76515917185e-08
ko04360	Axon guidance	71/1227	233/7206	2.93047932466e-07
ko03013	RNA transport	7/1227	166/7206	5.68457308395e-07
ko04022	cGMP-PKG signaling pathway	66/1227	216/7206	7.5010451483e-07
ko04971	Gastric acid secretion	37/1227	98/7206	8.72215901391e-07
ko05030	Cocaine addiction	30/1227	73/7206	9.36053749841e-07
ko05322	Systemic lupus erythematosus	6/1227	151/7206	9.91118213449e-07
ko05168	Herpes simplex infection	9/1227	182/7206	1.08982786374e-06
ko04740	Olfactory transduction	31/1227	80/7206	3.08425117281e-06
ko05203	Viral carcinogenesis	21/1227	277/7206	4.24632048763e-06
ko04070	Phosphatidylinositol signaling system	39/1227	112/7206	5.16808031515e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1227	74/7206	5.39011322071e-06
ko05164	Influenza A	9/1227	167/7206	8.96163155454e-06
ko04072	Phospholipase D signaling pathway	58/1227	197/7206	1.19805267212e-05
ko04010	MAPK signaling pathway	85/1227	321/7206	1.29831097344e-05
ko04060	Cytokine-cytokine receptor interaction	12/1227	191/7206	1.39295102913e-05
ko04514	Cell adhesion molecules (CAMs)	42/1227	130/7206	1.61853348012e-05
ko04730	Long-term depression	29/1227	78/7206	2.24500822487e-05
ko04014	Ras signaling pathway	75/1227	279/7206	2.93656404811e-05
ko04621	NOD-like receptor signaling pathway	9/1227	157/7206	3.52675025194e-05
ko04972	Pancreatic secretion	36/1227	111/7206	6.0019206595e-05
ko04924	Renin secretion	30/1227	86/7206	6.15112982499e-05
ko04966	Collecting duct acid secretion	13/1227	26/7206	0.00011024370354
ko03008	Ribosome biogenesis in eukaryotes	2/1227	79/7206	0.000111596311226
ko04540	Gap junction	39/1227	128/7206	0.000186515292907
ko04110	Cell cycle	9/1227	145/7206	0.000189714505112
ko04750	Inflammatory mediator regulation of TRP channels	37/1227	122/7206	0.000230973683624
ko04745	Phototransduction - fly	16/1227	38/7206	0.000235913161466
ko04141	Protein processing in endoplasmic reticulum	14/1227	184/7206	0.000304129222196
ko04923	Regulation of lipolysis in adipocytes	26/1227	77/7206	0.000332995598271
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1227	79/7206	0.000461615191966
ko05110	Vibrio cholerae infection	22/1227	63/7206	0.000547263784209
ko04915	Estrogen signaling pathway	38/1227	131/7206	0.000581824227201
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1227	59/7206	0.000650337283126
ko04612	Antigen processing and presentation	3/1227	77/7206	0.000677911284996
ko00520	Amino sugar and nucleotide sugar metabolism	1/1227	55/7206	0.000849500650145
ko05414	Dilated cardiomyopathy	33/1227	112/7206	0.000901644374554
ko04120	Ubiquitin mediated proteolysis	10/1227	138/7206	0.00122244610907
ko05162	Measles	8/1227	120/7206	0.00129417681821
ko04626	Plant-pathogen interaction	9/1227	18/7206	0.00130545648831
ko04976	Bile secretion	25/1227	80/7206	0.00149254471408
ko04710	Circadian rhythm	16/1227	43/7206	0.0015240553548
ko04964	Proximal tubule bicarbonate reclamation	12/1227	29/7206	0.00169940337136
ko00330	Arginine and proline metabolism	2/1227	61/7206	0.00173007913935
ko05169	Epstein-Barr virus infection	19/1227	206/7206	0.00179801046274
ko04371	Apelin signaling pathway	46/1227	177/7206	0.002254867738
ko04064	NF-kappa B signaling pathway	6/1227	96/7206	0.00249936784868
ko03420	Nucleotide excision repair	1/1227	46/7206	0.00283980329749
ko04930	Type II diabetes mellitus	18/1227	54/7206	0.00309256085009
ko05205	Proteoglycans in cancer	29/1227	271/7206	0.00382751334891
ko05161	Hepatitis B	16/1227	173/7206	0.00407672160528
ko04260	Cardiac muscle contraction	28/1227	98/7206	0.00409621671008
ko03022	Basal transcription factors	1/1227	44/7206	0.00426373320169
ko00071	Fatty acid degradation	1/1227	45/7206	0.00435029224922
ko00240	Pyrimidine metabolism	8/1227	110/7206	0.00453300969715
ko04270	Vascular smooth muscle contraction	40/1227	154/7206	0.00458642161816
ko05140	Leishmaniasis	4/1227	75/7206	0.00478994703159
ko04622	RIG-I-like receptor signaling pathway	3/1227	62/7206	0.00625170645127
ko04146	Peroxisome	6/1227	89/7206	0.00662482177437
ko00310	Lysine degradation	4/1227	73/7206	0.00690875845342
ko05231	Choline metabolism in cancer	35/1227	134/7206	0.00726261123989
ko03320	PPAR signaling pathway	4/1227	69/7206	0.00935508505093
ko04610	Complement and coagulation cascades	5/1227	79/7206	0.00958692192091
ko00562	Inositol phosphate metabolism	25/1227	89/7206	0.00976758512755
ko04912	GnRH signaling pathway	32/1227	122/7206	0.0101625683418
ko00380	Tryptophan metabolism	2/1227	50/7206	0.0123343374054
ko03018	RNA degradation	6/1227	84/7206	0.0124817572734
ko03410	Base excision repair	1/1227	38/7206	0.0149536956439
ko05131	Shigellosis	6/1227	82/7206	0.0171333618863
ko04916	Melanogenesis	35/1227	142/7206	0.0178138961965
ko04214	Apoptosis - fly	5/1227	72/7206	0.0178634248825
ko04115	p53 signaling pathway	5/1227	74/7206	0.0183487463454
ko04640	Hematopoietic cell lineage	4/1227	64/7206	0.0183981015994
ko04658	Th1 and Th2 cell differentiation	8/1227	96/7206	0.0197448984923
ko04217	Necroptosis	19/1227	178/7206	0.020131901782
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1227	14/7206	0.0209827829523
ko04657	IL-17 signaling pathway	7/1227	87/7206	0.0214523029966
ko05133	Pertussis	7/1227	87/7206	0.0214523029966
ko00860	Porphyrin and chlorophyll metabolism	1/1227	34/7206	0.0216920760281
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1227	100/7206	0.0219930563591
ko04015	Rap1 signaling pathway	62/1227	278/7206	0.0223282936996
ko04973	Carbohydrate digestion and absorption	13/1227	42/7206	0.0226131652233
ko04922	Glucagon signaling pathway	32/1227	128/7206	0.0232917194615
ko00590	Arachidonic acid metabolism	3/1227	52/7206	0.0258491506826
ko00280	Valine, leucine and isoleucine degradation	3/1227	54/7206	0.0269167299279
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1227	182/7206	0.0276605218962
ko00230	Purine metabolism	44/1227	194/7206	0.041410830101
ko04213	Longevity regulating pathway - multiple species	22/1227	86/7206	0.0422748607256
ko04918	Thyroid hormone synthesis	22/1227	86/7206	0.0422748607256
ko04722	Neurotrophin signaling pathway	37/1227	160/7206	0.0430461638727
ko04062	Chemokine signaling pathway	45/1227	201/7206	0.0453901774521
ko05166	HTLV-I infection	37/1227	292/7206	0.0465557824792
ko04630	Jak-STAT signaling pathway	14/1227	132/7206	0.0469491323149
ko05320	Autoimmune thyroid disease	1/1227	29/7206	0.0483081755552
ko05340	Primary immunodeficiency	1/1227	30/7206	0.0486752192278
ko05321	Inflammatory bowel disease (IBD)	4/1227	56/7206	0.0489185749471