ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	202/1247	423/7206	8.25814459086e-51
ko04724	Glutamatergic synapse	91/1247	152/7206	1.20792946179e-32
ko05033	Nicotine addiction	49/1247	56/7206	1.40286917775e-30
ko05032	Morphine addiction	68/1247	110/7206	8.64213695579e-26
ko04727	GABAergic synapse	67/1247	110/7206	6.89055656308e-25
ko04713	Circadian entrainment	75/1247	136/7206	6.36822461924e-24
ko04721	Synaptic vesicle cycle	52/1247	80/7206	1.91473886875e-21
ko04728	Dopaminergic synapse	83/1247	185/7206	8.93573270365e-19
ko04725	Cholinergic synapse	75/1247	160/7206	2.04667107154e-18
ko04723	Retrograde endocannabinoid signaling	78/1247	175/7206	1.67213821468e-17
ko04024	cAMP signaling pathway	105/1247	279/7206	1.36149916034e-16
ko04020	Calcium signaling pathway	100/1247	265/7206	7.92095954627e-16
ko04911	Insulin secretion	56/1247	117/7206	1.52337755925e-14
ko04742	Taste transduction	37/1247	61/7206	3.32185942834e-14
ko04744	Phototransduction	27/1247	36/7206	4.01183284903e-14
ko04726	Serotonergic synapse	61/1247	137/7206	6.40512703908e-14
ko04921	Oxytocin signaling pathway	77/1247	209/7206	6.35835064668e-12
ko05031	Amphetamine addiction	42/1247	91/7206	1.35117343552e-10
ko04720	Long-term potentiation	44/1247	99/7206	2.27483928123e-10
ko04261	Adrenergic signaling in cardiomyocytes	72/1247	205/7206	4.39971349296e-10
ko03040	Spliceosome	2/1247	145/7206	6.02004321364e-10
ko03010	Ribosome	1/1247	129/7206	9.30869475772e-10
ko04970	Salivary secretion	41/1247	95/7206	2.76883174868e-09
ko05203	Viral carcinogenesis	19/1247	277/7206	3.75193594373e-07
ko04740	Olfactory transduction	33/1247	80/7206	5.8540662663e-07
ko05168	Herpes simplex infection	9/1247	182/7206	7.43745206181e-07
ko04060	Cytokine-cytokine receptor interaction	10/1247	191/7206	8.25814995083e-07
ko05322	Systemic lupus erythematosus	6/1247	151/7206	1.00673490887e-06
ko04971	Gastric acid secretion	37/1247	98/7206	1.15038129132e-06
ko04925	Aldosterone synthesis and secretion	39/1247	105/7206	1.32897837409e-06
ko03013	RNA transport	8/1247	166/7206	1.9617139964e-06
ko05030	Cocaine addiction	30/1247	73/7206	2.20938680976e-06
ko04022	cGMP-PKG signaling pathway	65/1247	216/7206	2.47489224513e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1247	74/7206	2.59940178164e-06
ko04966	Collecting duct acid secretion	15/1247	26/7206	3.95171439206e-06
ko04360	Axon guidance	68/1247	233/7206	5.56844251237e-06
ko05164	Influenza A	9/1247	167/7206	6.16621096637e-06
ko04621	NOD-like receptor signaling pathway	9/1247	157/7206	2.44424805771e-05
ko04514	Cell adhesion molecules (CAMs)	42/1247	130/7206	3.00045058977e-05
ko04972	Pancreatic secretion	37/1247	111/7206	3.65151129662e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1247	79/7206	7.03645479575e-05
ko04924	Renin secretion	30/1247	86/7206	7.40578563643e-05
ko04745	Phototransduction - fly	17/1247	38/7206	7.42734844279e-05
ko05205	Proteoglycans in cancer	24/1247	271/7206	7.68438136318e-05
ko04070	Phosphatidylinositol signaling system	36/1247	112/7206	0.000120126408701
ko04976	Bile secretion	28/1247	80/7206	0.000135781254994
ko04010	MAPK signaling pathway	82/1247	321/7206	0.000147667410522
ko05140	Leishmaniasis	2/1247	75/7206	0.000159990041843
ko04141	Protein processing in endoplasmic reticulum	14/1247	184/7206	0.000160296347167
ko04064	NF-kappa B signaling pathway	4/1247	96/7206	0.000183197321185
ko04540	Gap junction	39/1247	128/7206	0.000215006290223
ko05161	Hepatitis B	13/1247	173/7206	0.000226984671503
ko05169	Epstein-Barr virus infection	17/1247	206/7206	0.000239896851592
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1247	79/7206	0.000250200673552
ko05110	Vibrio cholerae infection	23/1247	63/7206	0.000284785286466
ko04110	Cell cycle	10/1247	145/7206	0.000341869375865
ko05162	Measles	7/1247	120/7206	0.000343789588916
ko04072	Phospholipase D signaling pathway	54/1247	197/7206	0.000364947716313
ko04260	Cardiac muscle contraction	31/1247	98/7206	0.000419525390996
ko04610	Complement and coagulation cascades	3/1247	79/7206	0.000458035812871
ko04964	Proximal tubule bicarbonate reclamation	13/1247	29/7206	0.000511662288649
ko00520	Amino sugar and nucleotide sugar metabolism	1/1247	55/7206	0.000530373741921
ko05414	Dilated cardiomyopathy	34/1247	112/7206	0.00058584529834
ko04730	Long-term depression	26/1247	78/7206	0.000715232364549
ko04120	Ubiquitin mediated proteolysis	10/1247	138/7206	0.000878628145795
ko04626	Plant-pathogen interaction	9/1247	18/7206	0.00147173003989
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1247	59/7206	0.00166976153873
ko04146	Peroxisome	5/1247	89/7206	0.00170992263016
ko04710	Circadian rhythm	16/1247	43/7206	0.00171636696568
ko04612	Antigen processing and presentation	4/1247	77/7206	0.002285468822
ko03420	Nucleotide excision repair	1/1247	46/7206	0.00278945312178
ko04510	Focal adhesion	25/1247	240/7206	0.00308410721913
ko00240	Pyrimidine metabolism	8/1247	110/7206	0.00325418647541
ko04915	Estrogen signaling pathway	36/1247	131/7206	0.00332481860381
ko04750	Inflammatory mediator regulation of TRP channels	34/1247	122/7206	0.00346638682956
ko04014	Ras signaling pathway	67/1247	279/7206	0.00357234689039
ko05321	Inflammatory bowel disease (IBD)	2/1247	56/7206	0.0037872511414
ko03022	Basal transcription factors	1/1247	44/7206	0.00424476716016
ko04922	Glucagon signaling pathway	35/1247	128/7206	0.00433575594496
ko05144	Malaria	1/1247	45/7206	0.00446291680891
ko00071	Fatty acid degradation	1/1247	45/7206	0.00446291680891
ko00310	Lysine degradation	4/1247	73/7206	0.00463284810954
ko04630	Jak-STAT signaling pathway	11/1247	132/7206	0.00495433296692
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1247	14/7206	0.00506593881621
ko00590	Arachidonic acid metabolism	2/1247	52/7206	0.00543722636682
ko04923	Regulation of lipolysis in adipocytes	23/1247	77/7206	0.0058985809076
ko04622	RIG-I-like receptor signaling pathway	3/1247	62/7206	0.00622252112495
ko04657	IL-17 signaling pathway	6/1247	87/7206	0.00654509038111
ko05133	Pertussis	6/1247	87/7206	0.00654509038111
ko05145	Toxoplasmosis	11/1247	126/7206	0.00856017139593
ko00630	Glyoxylate and dicarboxylate metabolism	1/1247	38/7206	0.00958443908451
ko03410	Base excision repair	1/1247	38/7206	0.00958443908451
ko04930	Type II diabetes mellitus	17/1247	54/7206	0.0102447352894
ko05219	Bladder cancer	2/1247	48/7206	0.0116835782599
ko05131	Shigellosis	6/1247	82/7206	0.0123372623173
ko04115	p53 signaling pathway	5/1247	74/7206	0.0128155642674
ko05202	Transcriptional misregulation in cancer	20/1247	188/7206	0.0141799657971
ko04933	AGE-RAGE signaling pathway in diabetic complications	13/1247	135/7206	0.0155058902523
ko04371	Apelin signaling pathway	43/1247	177/7206	0.0156405850401
ko04210	Apoptosis	19/1247	180/7206	0.016126993299
ko00480	Glutathione metabolism	3/1247	55/7206	0.0183879253164
ko04658	Th1 and Th2 cell differentiation	8/1247	96/7206	0.0199149053766
ko05206	MicroRNAs in cancer	19/1247	177/7206	0.0201384785809
ko05166	HTLV-I infection	36/1247	292/7206	0.0217618147583
ko04620	Toll-like receptor signaling pathway	9/1247	100/7206	0.0236134599132
ko00330	Arginine and proline metabolism	4/1247	61/7206	0.0256121341242
ko03018	RNA degradation	7/1247	84/7206	0.0285879791805
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1247	100/7206	0.0319090268865
ko04217	Necroptosis	20/1247	178/7206	0.0344339077459
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1247	40/7206	0.0356356825554
ko05200	Pathways in cancer	68/1247	492/7206	0.0356501164487
ko04932	Non-alcoholic fatty liver disease (NAFLD)	21/1247	182/7206	0.0369455529138
ko04214	Apoptosis - fly	6/1247	72/7206	0.0416304839603
ko05215	Prostate cancer	11/1247	111/7206	0.0420128237081
ko04918	Thyroid hormone synthesis	22/1247	86/7206	0.0452125529792
ko04640	Hematopoietic cell lineage	5/1247	64/7206	0.0453599790901
ko00562	Inositol phosphate metabolism	23/1247	89/7206	0.0467552584349
ko04350	TGF-beta signaling pathway	10/1247	103/7206	0.0477293049617
ko05320	Autoimmune thyroid disease	1/1247	29/7206	0.047921980121
ko05340	Primary immunodeficiency	1/1247	30/7206	0.0490441583041
ko04670	Leukocyte transendothelial migration	17/1247	151/7206	0.0498514579921