ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	214/1274	423/7206	8.53944661393e-58
ko04724	Glutamatergic synapse	95/1274	152/7206	1.83197217023e-35
ko05033	Nicotine addiction	50/1274	56/7206	1.14219782529e-31
ko05032	Morphine addiction	74/1274	110/7206	6.37717427221e-31
ko04727	GABAergic synapse	72/1274	110/7206	5.95454724441e-29
ko04713	Circadian entrainment	80/1274	136/7206	2.14718940194e-27
ko04728	Dopaminergic synapse	90/1274	185/7206	1.21694339035e-22
ko04725	Cholinergic synapse	81/1274	160/7206	6.92899520189e-22
ko04721	Synaptic vesicle cycle	52/1274	80/7206	5.27194052029e-21
ko04024	cAMP signaling pathway	111/1274	279/7206	5.92018315751e-19
ko04723	Retrograde endocannabinoid signaling	81/1274	175/7206	8.79664379569e-19
ko04020	Calcium signaling pathway	107/1274	265/7206	1.19472335889e-18
ko04911	Insulin secretion	62/1274	117/7206	2.66641580463e-18
ko04726	Serotonergic synapse	66/1274	137/7206	1.29789252353e-16
ko04742	Taste transduction	39/1274	61/7206	1.0686576259e-15
ko04744	Phototransduction	28/1274	36/7206	4.63581451952e-15
ko04921	Oxytocin signaling pathway	84/1274	209/7206	7.93547729955e-15
ko04720	Long-term potentiation	49/1274	99/7206	3.17967105588e-13
ko04261	Adrenergic signaling in cardiomyocytes	78/1274	205/7206	2.40208363849e-12
ko05031	Amphetamine addiction	45/1274	91/7206	3.11253410576e-12
ko04740	Olfactory transduction	41/1274	80/7206	6.58893733112e-12
ko04970	Salivary secretion	45/1274	95/7206	2.06142181309e-11
ko03040	Spliceosome	1/1274	145/7206	2.62285304641e-11
ko04360	Axon guidance	78/1274	233/7206	4.16333380134e-09
ko04925	Aldosterone synthesis and secretion	44/1274	105/7206	5.61973397019e-09
ko04971	Gastric acid secretion	41/1274	98/7206	2.05203734022e-08
ko05030	Cocaine addiction	32/1274	73/7206	1.65229076798e-07
ko04070	Phosphatidylinositol signaling system	43/1274	112/7206	2.35065242368e-07
ko04022	cGMP-PKG signaling pathway	69/1274	216/7206	2.55349371088e-07
ko03013	RNA transport	7/1274	166/7206	2.56010595992e-07
ko05168	Herpes simplex infection	9/1274	182/7206	3.3771220683e-07
ko05322	Systemic lupus erythematosus	6/1274	151/7206	4.23740249783e-07
ko04540	Gap junction	46/1274	128/7206	8.54387071192e-07
ko05203	Viral carcinogenesis	21/1274	277/7206	1.17034347867e-06
ko04060	Cytokine-cytokine receptor interaction	11/1274	191/7206	1.71044934268e-06
ko04010	MAPK signaling pathway	90/1274	321/7206	2.8586091758e-06
ko05164	Influenza A	9/1274	167/7206	2.90036536569e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1274	74/7206	3.48826869324e-06
ko04745	Phototransduction - fly	19/1274	38/7206	5.1472772312e-06
ko04972	Pancreatic secretion	39/1274	111/7206	7.92855188353e-06
ko04141	Protein processing in endoplasmic reticulum	12/1274	184/7206	1.30153315494e-05
ko04730	Long-term depression	30/1274	78/7206	1.47292544216e-05
ko04621	NOD-like receptor signaling pathway	9/1274	157/7206	1.72059779889e-05
ko04966	Collecting duct acid secretion	14/1274	26/7206	3.14720503502e-05
ko04924	Renin secretion	31/1274	86/7206	4.34478030512e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1274	79/7206	4.46182325164e-05
ko04750	Inflammatory mediator regulation of TRP channels	40/1274	122/7206	5.72152616138e-05
ko04110	Cell cycle	9/1274	145/7206	6.47035075486e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1274	79/7206	7.27081587662e-05
ko05414	Dilated cardiomyopathy	37/1274	112/7206	8.02744722917e-05
ko04072	Phospholipase D signaling pathway	57/1274	197/7206	8.76053593306e-05
ko04514	Cell adhesion molecules (CAMs)	41/1274	130/7206	0.000103313043711
ko04014	Ras signaling pathway	74/1274	279/7206	0.00015891378037
ko05110	Vibrio cholerae infection	24/1274	63/7206	0.000160514580178
ko04120	Ubiquitin mediated proteolysis	9/1274	138/7206	0.000175015027395
ko05162	Measles	7/1274	120/7206	0.000238333874698
ko04915	Estrogen signaling pathway	40/1274	131/7206	0.00028597623911
ko04610	Complement and coagulation cascades	3/1274	79/7206	0.000301751496787
ko04146	Peroxisome	4/1274	89/7206	0.000369919064213
ko05169	Epstein-Barr virus infection	18/1274	206/7206	0.000385588847538
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1274	59/7206	0.000399016823742
ko04612	Antigen processing and presentation	3/1274	77/7206	0.000442978949061
ko05140	Leishmaniasis	3/1274	75/7206	0.000652482337112
ko04260	Cardiac muscle contraction	31/1274	98/7206	0.000718816449104
ko04923	Regulation of lipolysis in adipocytes	26/1274	77/7206	0.000733169180757
ko04371	Apelin signaling pathway	49/1274	177/7206	0.000902794457499
ko04976	Bile secretion	26/1274	80/7206	0.00107466466154
ko04657	IL-17 signaling pathway	5/1274	87/7206	0.00167037322534
ko04626	Plant-pathogen interaction	9/1274	18/7206	0.00172374299194
ko04064	NF-kappa B signaling pathway	6/1274	96/7206	0.00173010877854
ko00240	Pyrimidine metabolism	8/1274	110/7206	0.00233179823346
ko05321	Inflammatory bowel disease (IBD)	2/1274	56/7206	0.00245262063836
ko04912	GnRH signaling pathway	35/1274	122/7206	0.00252699983225
ko05205	Proteoglycans in cancer	30/1274	271/7206	0.00263536206794
ko05144	Malaria	1/1274	45/7206	0.00273024841756
ko00071	Fatty acid degradation	1/1274	45/7206	0.00273024841756
ko03420	Nucleotide excision repair	1/1274	46/7206	0.00282304476184
ko00562	Inositol phosphate metabolism	27/1274	89/7206	0.00304653796781
ko00310	Lysine degradation	4/1274	73/7206	0.00319047007701
ko00480	Glutathione metabolism	2/1274	55/7206	0.00374183452217
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1274	182/7206	0.00413846366273
ko04622	RIG-I-like receptor signaling pathway	3/1274	62/7206	0.0042098606235
ko03022	Basal transcription factors	1/1274	44/7206	0.00435775303212
ko04658	Th1 and Th2 cell differentiation	7/1274	96/7206	0.0045397822266
ko04214	Apoptosis - fly	4/1274	72/7206	0.00459733062366
ko00590	Arachidonic acid metabolism	2/1274	52/7206	0.00537855250334
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1274	14/7206	0.00573346565654
ko00330	Arginine and proline metabolism	3/1274	61/7206	0.00616236655464
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1274	40/7206	0.00622462109325
ko00140	Steroid hormone biosynthesis	1/1274	41/7206	0.0063410790469
ko04916	Melanogenesis	38/1274	142/7206	0.00723611184649
ko03018	RNA degradation	6/1274	84/7206	0.00893153778124
ko04918	Thyroid hormone synthesis	25/1274	86/7206	0.00963667669016
ko04015	Rap1 signaling pathway	66/1274	278/7206	0.0100503125275
ko05016	Huntington's disease	24/1274	215/7206	0.0107301436457
ko05161	Hepatitis B	18/1274	173/7206	0.0112395877144
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1274	100/7206	0.0113444678351
ko00260	Glycine, serine and threonine metabolism	2/1274	48/7206	0.0118999166038
ko05131	Shigellosis	6/1274	82/7206	0.0123866611386
ko04640	Hematopoietic cell lineage	4/1274	64/7206	0.0127978912991
ko04115	p53 signaling pathway	5/1274	74/7206	0.0130933166109
ko05145	Toxoplasmosis	12/1274	126/7206	0.0131016236939
ko04922	Glucagon signaling pathway	34/1274	128/7206	0.0134316343428
ko00982	Drug metabolism - cytochrome P450	1/1274	37/7206	0.0149063198539
ko05166	HTLV-I infection	36/1274	292/7206	0.0149231158776
ko05133	Pertussis	7/1274	87/7206	0.0155965393347
ko04270	Vascular smooth muscle contraction	39/1274	154/7206	0.0181982952313
ko05418	Fluid shear stress and atherosclerosis	19/1274	173/7206	0.019832659103
ko05231	Choline metabolism in cancer	34/1274	134/7206	0.0221141218775
ko01524	Platinum drug resistance	6/1274	76/7206	0.0226147387157
ko05132	Salmonella infection	9/1274	98/7206	0.0233104672044
ko04620	Toll-like receptor signaling pathway	9/1274	100/7206	0.0237698735052
ko03320	PPAR signaling pathway	5/1274	69/7206	0.0247872653553
ko05214	Glioma	22/1274	79/7206	0.0248825778892
ko04964	Proximal tubule bicarbonate reclamation	10/1274	29/7206	0.0260189788227
ko04722	Neurotrophin signaling pathway	39/1274	160/7206	0.0278461268447
ko04659	Th17 cell differentiation	10/1274	106/7206	0.028132730332
ko04630	Jak-STAT signaling pathway	14/1274	132/7206	0.0287739190175
ko04210	Apoptosis	21/1274	180/7206	0.0296586773947
ko05034	Alcoholism	55/1274	238/7206	0.0304419058184
ko04213	Longevity regulating pathway - multiple species	23/1274	86/7206	0.0324712235954
ko05204	Chemical carcinogenesis	3/1274	48/7206	0.0358184079598
ko04062	Chemokine signaling pathway	47/1274	201/7206	0.0385865828223
ko04973	Carbohydrate digestion and absorption	13/1274	42/7206	0.0391249807507
ko04142	Lysosome	17/1274	151/7206	0.0398211596973
ko04113	Meiosis - yeast	6/1274	70/7206	0.0412778981717
ko04710	Circadian rhythm	13/1274	43/7206	0.0424297073383
ko04114	Oocyte meiosis	34/1274	139/7206	0.0425338164042
ko01200	Carbon metabolism	14/1274	128/7206	0.0462597259418
ko05320	Autoimmune thyroid disease	1/1274	29/7206	0.0479394655847
ko00280	Valine, leucine and isoleucine degradation	4/1274	54/7206	0.0480809200424