ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	208/1308	423/7206	2.29092673453e-51
ko04724	Glutamatergic synapse	92/1308	152/7206	8.09311587383e-32
ko05033	Nicotine addiction	49/1308	56/7206	1.42041088685e-29
ko05032	Morphine addiction	71/1308	110/7206	2.96843296765e-27
ko04713	Circadian entrainment	78/1308	136/7206	5.99542232052e-25
ko04727	GABAergic synapse	68/1308	110/7206	1.58774152865e-24
ko04721	Synaptic vesicle cycle	52/1308	80/7206	1.82202345566e-20
ko04725	Cholinergic synapse	78/1308	160/7206	4.17420169674e-19
ko04728	Dopaminergic synapse	85/1308	185/7206	1.20668529088e-18
ko04024	cAMP signaling pathway	110/1308	279/7206	1.58366665269e-17
ko04723	Retrograde endocannabinoid signaling	79/1308	175/7206	7.51100427038e-17
ko04020	Calcium signaling pathway	103/1308	265/7206	7.49663946872e-16
ko04911	Insulin secretion	58/1308	117/7206	6.33068514928e-15
ko04742	Taste transduction	38/1308	61/7206	2.12477956772e-14
ko04744	Phototransduction	27/1308	36/7206	1.35121071462e-13
ko04726	Serotonergic synapse	62/1308	137/7206	1.52796007059e-13
ko04921	Oxytocin signaling pathway	80/1308	209/7206	3.62624052754e-12
ko05031	Amphetamine addiction	43/1308	91/7206	1.54969640064e-10
ko03040	Spliceosome	2/1308	145/7206	2.31886337532e-10
ko04720	Long-term potentiation	45/1308	99/7206	2.90535241116e-10
ko04261	Adrenergic signaling in cardiomyocytes	74/1308	205/7206	5.56429809528e-10
ko04970	Salivary secretion	43/1308	95/7206	8.5421896868e-10
ko04740	Olfactory transduction	37/1308	80/7206	6.24649093515e-09
ko04360	Axon guidance	77/1308	233/7206	3.08277204346e-08
ko05203	Viral carcinogenesis	19/1308	277/7206	6.745875584e-08
ko03013	RNA transport	7/1308	166/7206	1.09677716115e-07
ko04022	cGMP-PKG signaling pathway	70/1308	216/7206	3.42037277497e-07
ko04621	NOD-like receptor signaling pathway	7/1308	157/7206	5.03436037999e-07
ko04925	Aldosterone synthesis and secretion	41/1308	105/7206	5.27627020425e-07
ko05168	Herpes simplex infection	10/1308	182/7206	7.32191855524e-07
ko04060	Cytokine-cytokine receptor interaction	11/1308	191/7206	8.09232397818e-07
ko05322	Systemic lupus erythematosus	7/1308	151/7206	1.02652824605e-06
ko04070	Phosphatidylinositol signaling system	42/1308	112/7206	1.33045642884e-06
ko04971	Gastric acid secretion	38/1308	98/7206	1.80066678368e-06
ko05030	Cocaine addiction	30/1308	73/7206	4.14054902383e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1308	74/7206	5.53411106104e-06
ko04966	Collecting duct acid secretion	15/1308	26/7206	7.32105149131e-06
ko04141	Protein processing in endoplasmic reticulum	13/1308	184/7206	2.4515425849e-05
ko04924	Renin secretion	32/1308	86/7206	2.71461456025e-05
ko04745	Phototransduction - fly	18/1308	38/7206	3.4250888526e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1308	79/7206	4.53037192439e-05
ko04972	Pancreatic secretion	38/1308	111/7206	5.06230593905e-05
ko05164	Influenza A	12/1308	167/7206	6.27649945982e-05
ko05140	Leishmaniasis	2/1308	75/7206	6.5246474598e-05
ko04514	Cell adhesion molecules (CAMs)	42/1308	130/7206	7.86584321727e-05
ko04064	NF-kappa B signaling pathway	4/1308	96/7206	7.93481403032e-05
ko04010	MAPK signaling pathway	86/1308	321/7206	8.15743279533e-05
ko04540	Gap junction	41/1308	128/7206	0.000116438544951
ko04110	Cell cycle	10/1308	145/7206	0.00012186653918
ko04072	Phospholipase D signaling pathway	57/1308	197/7206	0.00016100189843
ko04730	Long-term depression	28/1308	78/7206	0.000166623302836
ko05110	Vibrio cholerae infection	24/1308	63/7206	0.000192464850924
ko04750	Inflammatory mediator regulation of TRP channels	39/1308	122/7206	0.000198566091863
ko04612	Antigen processing and presentation	3/1308	77/7206	0.000290804302439
ko04120	Ubiquitin mediated proteolysis	10/1308	138/7206	0.000320768966241
ko04976	Bile secretion	28/1308	80/7206	0.000342209458441
ko05169	Epstein-Barr virus infection	19/1308	206/7206	0.000446392794945
ko04014	Ras signaling pathway	74/1308	279/7206	0.000455979027528
ko04923	Regulation of lipolysis in adipocytes	27/1308	77/7206	0.000469546937178
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1308	79/7206	0.000591434679636
ko00240	Pyrimidine metabolism	7/1308	110/7206	0.000641023421428
ko05205	Proteoglycans in cancer	29/1308	271/7206	0.000717918396928
ko05414	Dilated cardiomyopathy	35/1308	112/7206	0.000729227166309
ko04146	Peroxisome	5/1308	89/7206	0.000805340968859
ko04964	Proximal tubule bicarbonate reclamation	13/1308	29/7206	0.000823771336248
ko04710	Circadian rhythm	17/1308	43/7206	0.000985988640777
ko04610	Complement and coagulation cascades	4/1308	79/7206	0.00105640732879
ko05161	Hepatitis B	16/1308	173/7206	0.00131514199902
ko03420	Nucleotide excision repair	1/1308	46/7206	0.0017509335735
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1308	59/7206	0.0017599092377
ko00562	Inositol phosphate metabolism	28/1308	89/7206	0.00209758997452
ko04260	Cardiac muscle contraction	30/1308	98/7206	0.00227008576225
ko00480	Glutathione metabolism	2/1308	55/7206	0.0023941139935
ko03022	Basal transcription factors	1/1308	44/7206	0.00266364219107
ko05144	Malaria	1/1308	45/7206	0.00277794655396
ko00071	Fatty acid degradation	1/1308	45/7206	0.00277794655396
ko00590	Arachidonic acid metabolism	2/1308	52/7206	0.00353444292119
ko05162	Measles	10/1308	120/7206	0.00382584664589
ko04915	Estrogen signaling pathway	37/1308	131/7206	0.00401696552085
ko04622	RIG-I-like receptor signaling pathway	3/1308	62/7206	0.00420608992849
ko04657	IL-17 signaling pathway	6/1308	87/7206	0.00462191329939
ko05133	Pertussis	6/1308	87/7206	0.00462191329939
ko05145	Toxoplasmosis	11/1308	126/7206	0.00476895316181
ko04371	Apelin signaling pathway	47/1308	177/7206	0.005427102176
ko03018	RNA degradation	6/1308	84/7206	0.00631523766191
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1308	14/7206	0.00666982276954
ko04930	Type II diabetes mellitus	18/1308	54/7206	0.00692946936169
ko04217	Necroptosis	19/1308	178/7206	0.0075993913993
ko05321	Inflammatory bowel disease (IBD)	3/1308	56/7206	0.00852547979469
ko05131	Shigellosis	6/1308	82/7206	0.00877979202727
ko00310	Lysine degradation	5/1308	73/7206	0.00890970875603
ko04626	Plant-pathogen interaction	8/1308	18/7206	0.00899440461689
ko00630	Glyoxylate and dicarboxylate metabolism	1/1308	38/7206	0.0095109964918
ko04658	Th1 and Th2 cell differentiation	8/1308	96/7206	0.0106567798959
ko04630	Jak-STAT signaling pathway	13/1308	132/7206	0.0116677540796
ko04214	Apoptosis - fly	5/1308	72/7206	0.0128021747076
ko05166	HTLV-I infection	37/1308	292/7206	0.0129090510254
ko04960	Aldosterone-regulated sodium reabsorption	14/1308	41/7206	0.0131872112336
ko00860	Porphyrin and chlorophyll metabolism	1/1308	34/7206	0.0139065559121
ko04973	Carbohydrate digestion and absorption	14/1308	42/7206	0.0154301494736
ko00330	Arginine and proline metabolism	4/1308	61/7206	0.018032672344
ko04711	Circadian rhythm - fly	6/1308	13/7206	0.018987251924
ko04922	Glucagon signaling pathway	34/1308	128/7206	0.0198936898041
ko04115	p53 signaling pathway	6/1308	74/7206	0.0222430248568
ko05231	Choline metabolism in cancer	35/1308	134/7206	0.02288853694
ko04210	Apoptosis	21/1308	180/7206	0.0237607213475
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1308	100/7206	0.0259075888573
ko04350	TGF-beta signaling pathway	10/1308	103/7206	0.0275665476983
ko05206	MicroRNAs in cancer	21/1308	177/7206	0.0293339223381
ko05016	Huntington's disease	27/1308	215/7206	0.030832550296
ko05340	Primary immunodeficiency	1/1308	30/7206	0.0312747842102
ko04640	Hematopoietic cell lineage	5/1308	64/7206	0.0327182080415
ko03410	Base excision repair	2/1308	38/7206	0.0347460069667
ko00260	Glycine, serine and threonine metabolism	3/1308	48/7206	0.036266423926
ko05219	Bladder cancer	3/1308	48/7206	0.036266423926
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1308	40/7206	0.0364244822526
ko04142	Lysosome	18/1308	151/7206	0.0428754466966
ko04270	Vascular smooth muscle contraction	38/1308	154/7206	0.0438324430833
ko01212	Fatty acid metabolism	5/1308	60/7206	0.044308223074
ko04213	Longevity regulating pathway - multiple species	23/1308	86/7206	0.0475756752927
ko04918	Thyroid hormone synthesis	23/1308	86/7206	0.0475756752927
ko00280	Valine, leucine and isoleucine degradation	4/1308	54/7206	0.0487630463186
ko05320	Autoimmune thyroid disease	1/1308	29/7206	0.0488327118978
ko04510	Focal adhesion	32/1308	240/7206	0.049997157118