ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	170/1108	423/7206	1.42302845563e-37
ko04724	Glutamatergic synapse	82/1108	152/7206	7.31356794874e-29
ko05033	Nicotine addiction	44/1108	56/7206	6.78076988437e-26
ko04727	GABAergic synapse	62/1108	110/7206	2.0020445499e-23
ko05032	Morphine addiction	62/1108	110/7206	2.0020445499e-23
ko04728	Dopaminergic synapse	80/1108	185/7206	3.49532992832e-20
ko04713	Circadian entrainment	66/1108	136/7206	4.14537721288e-20
ko04721	Synaptic vesicle cycle	46/1108	80/7206	3.73075830669e-18
ko04725	Cholinergic synapse	70/1108	160/7206	3.99781618636e-18
ko04723	Retrograde endocannabinoid signaling	73/1108	175/7206	1.91241816852e-17
ko04024	cAMP signaling pathway	96/1108	279/7206	7.85460672422e-16
ko04911	Insulin secretion	52/1108	117/7206	4.14210759914e-14
ko04020	Calcium signaling pathway	89/1108	265/7206	5.29356247534e-14
ko04921	Oxytocin signaling pathway	73/1108	209/7206	1.42857413793e-12
ko04742	Taste transduction	33/1108	61/7206	2.29447945073e-12
ko04744	Phototransduction	24/1108	36/7206	4.72544718713e-12
ko04726	Serotonergic synapse	54/1108	137/7206	4.95888124973e-12
ko04261	Adrenergic signaling in cardiomyocytes	68/1108	205/7206	1.04950818855e-10
ko05031	Amphetamine addiction	39/1108	91/7206	2.52583703101e-10
ko03040	Spliceosome	1/1108	145/7206	1.39058241335e-09
ko04970	Salivary secretion	38/1108	95/7206	4.57664090102e-09
ko04720	Long-term potentiation	38/1108	99/7206	1.7614063627e-08
ko03010	Ribosome	1/1108	129/7206	1.77038791282e-08
ko05203	Viral carcinogenesis	15/1108	277/7206	2.45839108177e-07
ko04070	Phosphatidylinositol signaling system	39/1108	112/7206	3.86240522562e-07
ko05322	Systemic lupus erythematosus	4/1108	151/7206	4.98862722194e-07
ko04966	Collecting duct acid secretion	15/1108	26/7206	8.38411133792e-07
ko04925	Aldosterone synthesis and secretion	36/1108	105/7206	1.5236069984e-06
ko04971	Gastric acid secretion	34/1108	98/7206	1.65986505115e-06
ko03013	RNA transport	6/1108	166/7206	1.79350556757e-06
ko05168	Herpes simplex infection	8/1108	182/7206	3.41102588514e-06
ko05164	Influenza A	7/1108	167/7206	6.14751063201e-06
ko04972	Pancreatic secretion	36/1108	111/7206	6.55608567244e-06
ko04022	cGMP-PKG signaling pathway	58/1108	216/7206	1.25617070769e-05
ko04745	Phototransduction - fly	17/1108	38/7206	1.53469323164e-05
ko04060	Cytokine-cytokine receptor interaction	10/1108	191/7206	1.55764834649e-05
ko05030	Cocaine addiction	26/1108	73/7206	2.0355131932e-05
ko04514	Cell adhesion molecules (CAMs)	39/1108	130/7206	2.06628844921e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1108	74/7206	2.46020544269e-05
ko05110	Vibrio cholerae infection	23/1108	63/7206	3.03479006086e-05
ko04120	Ubiquitin mediated proteolysis	6/1108	138/7206	6.5296304151e-05
ko04621	NOD-like receptor signaling pathway	8/1108	157/7206	7.58273391782e-05
ko05169	Epstein-Barr virus infection	13/1108	206/7206	7.78611829611e-05
ko04612	Antigen processing and presentation	1/1108	77/7206	8.2149682453e-05
ko04110	Cell cycle	7/1108	145/7206	0.000100655709694
ko04710	Circadian rhythm	17/1108	43/7206	0.000104613928117
ko04072	Phospholipase D signaling pathway	51/1108	197/7206	0.000118689122682
ko04360	Axon guidance	58/1108	233/7206	0.000133083215808
ko04730	Long-term depression	25/1108	78/7206	0.000195760874168
ko04014	Ras signaling pathway	65/1108	279/7206	0.000358183069542
ko03008	Ribosome biogenesis in eukaryotes	2/1108	79/7206	0.000413157657426
ko04740	Olfactory transduction	25/1108	80/7206	0.000435886897962
ko04976	Bile secretion	25/1108	80/7206	0.000435886897962
ko05140	Leishmaniasis	2/1108	75/7206	0.000595943937292
ko04964	Proximal tubule bicarbonate reclamation	12/1108	29/7206	0.000669251526471
ko05162	Measles	6/1108	120/7206	0.000757480818267
ko05414	Dilated cardiomyopathy	31/1108	112/7206	0.000803855687284
ko04141	Protein processing in endoplasmic reticulum	13/1108	184/7206	0.000845505097689
ko04750	Inflammatory mediator regulation of TRP channels	33/1108	122/7206	0.000849580327343
ko05161	Hepatitis B	12/1108	173/7206	0.000897444924882
ko04010	MAPK signaling pathway	71/1108	321/7206	0.00111195259992
ko04924	Renin secretion	25/1108	86/7206	0.00127365366914
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/1108	79/7206	0.00154246329706
ko04260	Cardiac muscle contraction	27/1108	98/7206	0.00170805411691
ko00520	Amino sugar and nucleotide sugar metabolism	1/1108	55/7206	0.00209725587101
ko04610	Complement and coagulation cascades	3/1108	79/7206	0.00239252172421
ko04626	Plant-pathogen interaction	8/1108	18/7206	0.00315157362316
ko05205	Proteoglycans in cancer	25/1108	271/7206	0.0033828734896
ko04064	NF-kappa B signaling pathway	5/1108	96/7206	0.00386869570812
ko04540	Gap junction	32/1108	128/7206	0.00414307948354
ko05166	HTLV-I infection	28/1108	292/7206	0.00468756811552
ko04630	Jak-STAT signaling pathway	9/1108	132/7206	0.00469447210813
ko04923	Regulation of lipolysis in adipocytes	21/1108	77/7206	0.00638671040019
ko04915	Estrogen signaling pathway	32/1108	131/7206	0.00666745346496
ko03420	Nucleotide excision repair	1/1108	46/7206	0.00692520565303
ko04930	Type II diabetes mellitus	16/1108	54/7206	0.00700832307166
ko05219	Bladder cancer	1/1108	48/7206	0.00739903076154
ko05321	Inflammatory bowel disease (IBD)	2/1108	56/7206	0.00865694899383
ko04657	IL-17 signaling pathway	5/1108	87/7206	0.0101580013626
ko03022	Basal transcription factors	1/1108	44/7206	0.0104314957735
ko05231	Choline metabolism in cancer	32/1108	134/7206	0.0104771168774
ko05144	Malaria	1/1108	45/7206	0.0108339330615
ko04371	Apelin signaling pathway	40/1108	177/7206	0.01086733406
ko00562	Inositol phosphate metabolism	23/1108	89/7206	0.0109263180481
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1108	100/7206	0.0112895003069
ko00290	Valine, leucine and isoleucine biosynthesis	3/1108	4/7206	0.0128385574949
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1108	14/7206	0.0129098555783
ko02010	ABC transporters	12/1108	39/7206	0.012972418481
ko04115	p53 signaling pathway	4/1108	74/7206	0.0140860610468
ko00240	Pyrimidine metabolism	8/1108	110/7206	0.0158037005224
ko05215	Prostate cancer	8/1108	111/7206	0.016061463508
ko05145	Toxoplasmosis	10/1108	126/7206	0.0174257048777
ko04113	Meiosis - yeast	4/1108	70/7206	0.0194558968212
ko04622	RIG-I-like receptor signaling pathway	3/1108	62/7206	0.0197793274287
ko04658	Th1 and Th2 cell differentiation	7/1108	96/7206	0.0226916516474
ko03410	Base excision repair	1/1108	38/7206	0.0229450050834
ko05133	Pertussis	6/1108	87/7206	0.024375263473
ko04922	Glucagon signaling pathway	29/1108	128/7206	0.0257859677887
ko04960	Aldosterone-regulated sodium reabsorption	12/1108	41/7206	0.0262177632625
ko04217	Necroptosis	17/1108	178/7206	0.0270202212244
ko04210	Apoptosis	17/1108	180/7206	0.0273015648809
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1108	92/7206	0.0284519777246
ko04510	Focal adhesion	25/1108	240/7206	0.0288366361142
ko03018	RNA degradation	6/1108	84/7206	0.0327823915614
ko04711	Circadian rhythm - fly	5/1108	13/7206	0.0374706467853
ko00071	Fatty acid degradation	2/1108	45/7206	0.0377164248234
ko04270	Vascular smooth muscle contraction	33/1108	154/7206	0.0415862033425
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/1108	59/7206	0.0438526362889
ko04114	Oocyte meiosis	30/1108	139/7206	0.0438707890764
ko05131	Shigellosis	6/1108	82/7206	0.0440952938062
ko05200	Pathways in cancer	60/1108	492/7206	0.0445616169805
ko04978	Mineral absorption	11/1108	40/7206	0.0450257709387
ko04214	Apoptosis - fly	5/1108	72/7206	0.0477529308569
ko04918	Thyroid hormone synthesis	20/1108	86/7206	0.0496848667159