ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 45/426 191/7206 2.77464495798e-16 ko04380 Osteoclast differentiation 33/426 134/7206 8.42592475681e-13 ko05340 Primary immunodeficiency 15/426 30/7206 2.02272626317e-11 ko04621 NOD-like receptor signaling pathway 32/426 157/7206 3.93903225295e-10 ko04650 Natural killer cell mediated cytotoxicity 24/426 97/7206 1.09178019246e-09 ko05164 Influenza A 32/426 167/7206 2.03385998472e-09 ko05140 Leishmaniasis 20/426 75/7206 6.80868190454e-09 ko05162 Measles 24/426 120/7206 9.58471777242e-08 ko05145 Toxoplasmosis 24/426 126/7206 2.51532672598e-07 ko04620 Toll-like receptor signaling pathway 21/426 100/7206 2.59263224764e-07 ko05321 Inflammatory bowel disease (IBD) 15/426 56/7206 5.08591040736e-07 ko05150 Staphylococcus aureus infection 12/426 36/7206 5.33007917534e-07 ko04659 Th17 cell differentiation 21/426 106/7206 7.25959815322e-07 ko00120 Primary bile acid biosynthesis 9/426 20/7206 7.59633281082e-07 ko05168 Herpes simplex infection 28/426 182/7206 2.44932582544e-06 ko04658 Th1 and Th2 cell differentiation 19/426 96/7206 2.50296730451e-06 ko04660 T cell receptor signaling pathway 22/426 124/7206 2.7948398573e-06 ko05320 Autoimmune thyroid disease 10/426 29/7206 3.39885665863e-06 ko05152 Tuberculosis 28/426 187/7206 4.21895348888e-06 ko05330 Allograft rejection 9/426 24/7206 4.77919007939e-06 ko04217 Necroptosis 27/426 178/7206 4.89247101954e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 28/426 191/7206 6.40887917586e-06 ko04630 Jak-STAT signaling pathway 22/426 132/7206 8.07477332408e-06 ko04612 Antigen processing and presentation 16/426 77/7206 8.11777024529e-06 ko04064 NF-kappa B signaling pathway 18/426 96/7206 1.02200055129e-05 ko04610 Complement and coagulation cascades 16/426 79/7206 1.14774035516e-05 ko04672 Intestinal immune network for IgA production 10/426 37/7206 3.85234142636e-05 ko05133 Pertussis 16/426 87/7206 4.06850527036e-05 ko05332 Graft-versus-host disease 7/426 18/7206 4.32286248283e-05 ko04662 B cell receptor signaling pathway 16/426 88/7206 4.70797145381e-05 ko04062 Chemokine signaling pathway 27/426 201/7206 5.07713729599e-05 ko05323 Rheumatoid arthritis 16/426 89/7206 5.43443272298e-05 ko04623 Cytosolic DNA-sensing pathway 10/426 41/7206 0.000100155348415 ko05144 Malaria 10/426 45/7206 0.000230315306225 ko04640 Hematopoietic cell lineage 12/426 64/7206 0.000307997792027 ko05034 Alcoholism 3/426 238/7206 0.000636119611684 ko03013 RNA transport 1/426 166/7206 0.000704057955626 ko04666 Fc gamma R-mediated phagocytosis 17/426 122/7206 0.000775886752472 ko05161 Hepatitis B 22/426 173/7206 0.000793190885833 ko04622 RIG-I-like receptor signaling pathway 11/426 62/7206 0.000888045809499 ko04137 Mitophagy - animal 13/426 82/7206 0.000947343879025 ko05142 Chagas disease (American trypanosomiasis) 17/426 130/7206 0.001929371764 ko04310 Wnt signaling pathway 2/426 181/7206 0.00207854719725 ko03040 Spliceosome 1/426 145/7206 0.00220896377833 ko04940 Type I diabetes mellitus 7/426 32/7206 0.00222282474308 ko05310 Asthma 5/426 17/7206 0.00241130295841 ko04360 Axon guidance 4/426 233/7206 0.0027438611075 ko00590 Arachidonic acid metabolism 9/426 52/7206 0.00306993652159 ko04916 Melanogenesis 1/426 142/7206 0.00329633626322 ko04145 Phagosome 19/426 162/7206 0.00365224719924 ko03050 Proteasome 9/426 54/7206 0.00399720387868 ko00592 alpha-Linolenic acid metabolism 5/426 19/7206 0.00410792687319 ko04668 TNF signaling pathway 15/426 120/7206 0.00517602486391 ko04146 Peroxisome 12/426 89/7206 0.00584407947004 ko04728 Dopaminergic synapse 3/426 185/7206 0.00684059723273 ko04390 Hippo signaling pathway 3/426 188/7206 0.00693274668427 ko03010 Ribosome 1/426 129/7206 0.00703897581566 ko04080 Neuroactive ligand-receptor interaction 13/426 423/7206 0.00775408073317 ko00980 Metabolism of xenobiotics by cytochrome P450 7/426 40/7206 0.00818982436432 ko04110 Cell cycle 2/426 145/7206 0.0121332421915 ko04910 Insulin signaling pathway 3/426 172/7206 0.0133005883573 ko05160 Hepatitis C 17/426 153/7206 0.0133801526803 ko05224 Breast cancer 3/426 174/7206 0.0134507430866 ko04723 Retrograde endocannabinoid signaling 3/426 175/7206 0.0135771870319 ko04210 Apoptosis 19/426 180/7206 0.0147315066035 ko05132 Salmonella infection 12/426 98/7206 0.0148498328534 ko04911 Insulin secretion 1/426 117/7206 0.0152164333579 ko04020 Calcium signaling pathway 7/426 265/7206 0.0166215867786 ko04114 Oocyte meiosis 2/426 139/7206 0.0171800596867 ko00982 Drug metabolism - cytochrome P450 6/426 37/7206 0.0201027705903 ko04012 ErbB signaling pathway 1/426 109/7206 0.0215509486779 ko05204 Chemical carcinogenesis 7/426 48/7206 0.0215912878965 ko04514 Cell adhesion molecules (CAMs) 14/426 130/7206 0.0240812388361 ko04611 Platelet activation 17/426 163/7206 0.0266304192326 ko05131 Shigellosis 10/426 82/7206 0.0285944160908 ko05020 Prion diseases 6/426 40/7206 0.0286254414004 ko04971 Gastric acid secretion 1/426 98/7206 0.0301244088612 ko04720 Long-term potentiation 1/426 99/7206 0.0301944636989 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/426 5/7206 0.0309446360512 ko04540 Gap junction 2/426 128/7206 0.0347148579797 ko04724 Glutamatergic synapse 3/426 152/7206 0.0352295125029 ko00051 Fructose and mannose metabolism 6/426 42/7206 0.035459163605 ko00565 Ether lipid metabolism 6/426 42/7206 0.035459163605 ko00480 Glutathione metabolism 7/426 55/7206 0.0419150092779 ko05416 Viral myocarditis 7/426 55/7206 0.0419150092779 ko00350 Tyrosine metabolism 5/426 33/7206 0.04260416419 ko04664 Fc epsilon RI signaling pathway 9/426 77/7206 0.0458324364897