ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 52/517 191/7206 6.26191618841e-18 ko04621 NOD-like receptor signaling pathway 39/517 157/7206 2.55672253577e-12 ko04380 Osteoclast differentiation 35/517 134/7206 7.51960356746e-12 ko05340 Primary immunodeficiency 16/517 30/7206 2.23202709955e-11 ko04064 NF-kappa B signaling pathway 26/517 96/7206 1.70748876483e-09 ko05164 Influenza A 35/517 167/7206 5.0014977371e-09 ko00120 Primary bile acid biosynthesis 11/517 20/7206 2.16617380754e-08 ko04217 Necroptosis 35/517 178/7206 2.84234935194e-08 ko04650 Natural killer cell mediated cytotoxicity 24/517 97/7206 4.99962730336e-08 ko05140 Leishmaniasis 20/517 75/7206 1.75859708941e-07 ko05145 Toxoplasmosis 27/517 126/7206 1.8390539994e-07 ko05321 Inflammatory bowel disease (IBD) 17/517 56/7206 1.92360524278e-07 ko04640 Hematopoietic cell lineage 18/517 64/7206 3.04588118509e-07 ko04620 Toll-like receptor signaling pathway 23/517 100/7206 3.9754178887e-07 ko04610 Complement and coagulation cascades 20/517 79/7206 4.42492054978e-07 ko05150 Staphylococcus aureus infection 13/517 36/7206 5.72356100954e-07 ko05162 Measles 25/517 120/7206 9.21926409768e-07 ko04612 Antigen processing and presentation 19/517 77/7206 1.31521101527e-06 ko05330 Allograft rejection 10/517 24/7206 2.59401188836e-06 ko05168 Herpes simplex infection 30/517 182/7206 1.39302716654e-05 ko05332 Graft-versus-host disease 8/517 18/7206 1.52935829896e-05 ko04659 Th17 cell differentiation 21/517 106/7206 1.56714799888e-05 ko04630 Jak-STAT signaling pathway 24/517 132/7206 1.81075409822e-05 ko05320 Autoimmune thyroid disease 10/517 29/7206 1.90785097541e-05 ko04310 Wnt signaling pathway 1/517 181/7206 2.95672777942e-05 ko05133 Pertussis 18/517 87/7206 3.43755048109e-05 ko04672 Intestinal immune network for IgA production 11/517 37/7206 3.58011663982e-05 ko05323 Rheumatoid arthritis 18/517 89/7206 4.73360251821e-05 ko04660 T cell receptor signaling pathway 22/517 124/7206 5.94135074188e-05 ko05152 Tuberculosis 29/517 187/7206 6.93625470316e-05 ko04622 RIG-I-like receptor signaling pathway 14/517 62/7206 9.41117425705e-05 ko03013 RNA transport 1/517 166/7206 9.66973271334e-05 ko04658 Th1 and Th2 cell differentiation 18/517 96/7206 0.000133262451433 ko05144 Malaria 11/517 45/7206 0.000251144828393 ko05167 Kaposi's sarcoma-associated herpesvirus infection 28/517 191/7206 0.000279394681037 ko04916 Melanogenesis 1/517 142/7206 0.000453047378817 ko03040 Spliceosome 1/517 145/7206 0.000464960808226 ko05224 Breast cancer 2/517 174/7206 0.000475085903657 ko04623 Cytosolic DNA-sensing pathway 10/517 41/7206 0.000487608771347 ko04146 Peroxisome 16/517 89/7206 0.000510088875937 ko04062 Chemokine signaling pathway 28/517 201/7206 0.000697075831815 ko05310 Asthma 6/517 17/7206 0.000827499072603 ko00360 Phenylalanine metabolism 6/517 17/7206 0.000827499072603 ko04390 Hippo signaling pathway 3/517 188/7206 0.000839031205212 ko03320 PPAR signaling pathway 13/517 69/7206 0.00106796447813 ko04210 Apoptosis 25/517 180/7206 0.00115990455664 ko04728 Dopaminergic synapse 3/517 185/7206 0.00122911456217 ko04662 B cell receptor signaling pathway 15/517 88/7206 0.00133748593016 ko03010 Ribosome 1/517 129/7206 0.00149166280065 ko04940 Type I diabetes mellitus 8/517 32/7206 0.00149983209012 ko04723 Retrograde endocannabinoid signaling 3/517 175/7206 0.00168291041985 ko04137 Mitophagy - animal 14/517 82/7206 0.0018853002643 ko00983 Drug metabolism - other enzymes 9/517 42/7206 0.00246886126131 ko05142 Chagas disease (American trypanosomiasis) 19/517 130/7206 0.002833204704 ko04360 Axon guidance 6/517 233/7206 0.0028493614411 ko04110 Cell cycle 2/517 145/7206 0.00289151014092 ko05034 Alcoholism 6/517 238/7206 0.00294053915947 ko04911 Insulin secretion 1/517 117/7206 0.00314265288375 ko00590 Arachidonic acid metabolism 10/517 52/7206 0.00337285276551 ko04668 TNF signaling pathway 18/517 120/7206 0.00338874434784 ko00950 Isoquinoline alkaloid biosynthesis 4/517 10/7206 0.00387964541726 ko05161 Hepatitis B 23/517 173/7206 0.00397855155268 ko00982 Drug metabolism - cytochrome P450 8/517 37/7206 0.00400866894323 ko00071 Fatty acid degradation 9/517 45/7206 0.00404910981747 ko04713 Circadian entrainment 2/517 136/7206 0.00406143478921 ko04012 ErbB signaling pathway 1/517 109/7206 0.00449764468247 ko04020 Calcium signaling pathway 8/517 265/7206 0.00496645083089 ko00362 Benzoate degradation 3/517 6/7206 0.00623277631285 ko05204 Chemical carcinogenesis 9/517 48/7206 0.00632726844572 ko00980 Metabolism of xenobiotics by cytochrome P450 8/517 40/7206 0.0066064088966 ko04666 Fc gamma R-mediated phagocytosis 17/517 122/7206 0.00711708401071 ko00140 Steroid hormone biosynthesis 8/517 41/7206 0.00770655098321 ko00350 Tyrosine metabolism 7/517 33/7206 0.00779496146112 ko04080 Neuroactive ligand-receptor interaction 17/517 423/7206 0.00839511597193 ko04540 Gap junction 2/517 128/7206 0.00841126445773 ko00592 alpha-Linolenic acid metabolism 5/517 19/7206 0.00932654817683 ko04910 Insulin signaling pathway 4/517 172/7206 0.00997945109704 ko05160 Hepatitis C 20/517 153/7206 0.00999492902324 ko03050 Proteasome 9/517 54/7206 0.013700805983 ko04114 Oocyte meiosis 3/517 139/7206 0.0184119102829 ko05134 Legionellosis 11/517 74/7206 0.0196254310033 ko05032 Morphine addiction 2/517 110/7206 0.0236813934703 ko00380 Tryptophan metabolism 8/517 50/7206 0.0246372811219 ko04915 Estrogen signaling pathway 3/517 131/7206 0.0248964580168 ko04724 Glutamatergic synapse 4/517 152/7206 0.0249122528005 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/517 4/7206 0.0279693394459 ko00051 Fructose and mannose metabolism 7/517 42/7206 0.0282368448131 ko01040 Biosynthesis of unsaturated fatty acids 5/517 25/7206 0.0298861177062 ko04145 Phagosome 19/517 162/7206 0.0301330744857 ko04611 Platelet activation 19/517 163/7206 0.0310784789647 ko04550 Signaling pathways regulating pluripotency of stem cells 5/517 165/7206 0.0322377672011 ko01522 Endocrine resistance 3/517 124/7206 0.0341498012663 ko05418 Fluid shear stress and atherosclerosis 20/517 173/7206 0.0348864899094 ko04514 Cell adhesion molecules (CAMs) 16/517 130/7206 0.0367239950764 ko01212 Fatty acid metabolism 9/517 60/7206 0.0373352719318 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/517 5/7206 0.0444214091458 ko00281 Geraniol degradation 2/517 5/7206 0.0444214091458 ko04721 Synaptic vesicle cycle 1/517 80/7206 0.0449327304691 ko04971 Gastric acid secretion 2/517 98/7206 0.0466208515602 ko04720 Long-term potentiation 2/517 99/7206 0.0470120790059 ko04912 GnRH signaling pathway 3/517 122/7206 0.0484733384999