ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 59/294 145/7206 3.6542516968e-45 ko03008 Ribosome biogenesis in eukaryotes 26/294 79/7206 1.87377665492e-17 ko03013 RNA transport 31/294 166/7206 5.27634392435e-13 ko04110 Cell cycle 27/294 145/7206 1.95555714011e-11 ko03030 DNA replication 14/294 38/7206 1.04211298159e-10 ko04111 Cell cycle - yeast 18/294 90/7206 1.54733061158e-08 ko00240 Pyrimidine metabolism 19/294 110/7206 7.48835121381e-08 ko03020 RNA polymerase 10/294 29/7206 1.10347403027e-07 ko03015 mRNA surveillance pathway 17/294 93/7206 1.57650767956e-07 ko03460 Fanconi anemia pathway 12/294 51/7206 6.46914402783e-07 ko03430 Mismatch repair 8/294 22/7206 1.354901555e-06 ko03410 Base excision repair 10/294 38/7206 1.87743958824e-06 ko03018 RNA degradation 13/294 84/7206 3.06884916119e-05 ko03022 Basal transcription factors 9/294 44/7206 5.57111185399e-05 ko03420 Nucleotide excision repair 9/294 46/7206 8.05780343253e-05 ko04113 Meiosis - yeast 11/294 70/7206 0.000108922240162 ko03440 Homologous recombination 8/294 41/7206 0.00020566204083 ko04810 Regulation of actin cytoskeleton 1/294 264/7206 0.000351576408055 ko05169 Epstein-Barr virus infection 19/294 206/7206 0.000875286760663 ko04114 Oocyte meiosis 14/294 139/7206 0.00153598190253 ko04015 Rap1 signaling pathway 2/294 278/7206 0.00158730917007 ko05168 Herpes simplex infection 17/294 182/7206 0.00163021424405 ko05166 HTLV-I infection 23/294 292/7206 0.00218860805475 ko05222 Small cell lung cancer 10/294 89/7206 0.0032096826686 ko05010 Alzheimer's disease 1/294 202/7206 0.00338355395641 ko04120 Ubiquitin mediated proteolysis 13/294 138/7206 0.00403089301975 ko04024 cAMP signaling pathway 3/294 279/7206 0.00503711383362 ko04014 Ras signaling pathway 3/294 279/7206 0.00503711383362 ko04530 Tight junction 2/294 228/7206 0.00930710468046 ko04921 Oxytocin signaling pathway 2/294 209/7206 0.0125660142284 ko04022 cGMP-PKG signaling pathway 2/294 216/7206 0.0128995200336 ko04010 MAPK signaling pathway 5/294 321/7206 0.0138222683344 ko04145 Phagosome 1/294 162/7206 0.0149939131512 ko00230 Purine metabolism 15/294 194/7206 0.0153694602213 ko04151 PI3K-Akt signaling pathway 7/294 390/7206 0.0169121499097 ko04062 Chemokine signaling pathway 2/294 201/7206 0.017742966623 ko04261 Adrenergic signaling in cardiomyocytes 2/294 205/7206 0.0180572424404 ko04510 Focal adhesion 3/294 240/7206 0.0189958951018 ko04724 Glutamatergic synapse 1/294 152/7206 0.0216493022295 ko04270 Vascular smooth muscle contraction 1/294 154/7206 0.0217475073133 ko04621 NOD-like receptor signaling pathway 1/294 157/7206 0.0221680588034 ko04725 Cholinergic synapse 1/294 160/7206 0.0229179945788 ko05203 Viral carcinogenesis 19/294 277/7206 0.0280626570523 ko04115 p53 signaling pathway 7/294 74/7206 0.0305854793228 ko05322 Systemic lupus erythematosus 12/294 151/7206 0.0333408705914 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/294 182/7206 0.0350892527002 ko04914 Progesterone-mediated oocyte maturation 9/294 104/7206 0.0384109291995 ko04380 Osteoclast differentiation 1/294 134/7206 0.0449973171848 ko05231 Choline metabolism in cancer 1/294 134/7206 0.0449973171848 ko04713 Circadian entrainment 1/294 136/7206 0.0454405781056 ko04726 Serotonergic synapse 1/294 137/7206 0.0457638073823 ko04723 Retrograde endocannabinoid signaling 2/294 175/7206 0.0497450437378