ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	176/1124	423/7206	1.70868703432e-40
ko04724	Glutamatergic synapse	90/1124	152/7206	1.91791351737e-35
ko05032	Morphine addiction	72/1124	110/7206	1.38886957399e-32
ko05033	Nicotine addiction	48/1124	56/7206	3.10702112307e-31
ko04727	GABAergic synapse	68/1124	110/7206	1.40048367554e-28
ko04713	Circadian entrainment	76/1124	136/7206	9.74050840403e-28
ko04728	Dopaminergic synapse	84/1124	185/7206	1.95151253513e-22
ko04723	Retrograde endocannabinoid signaling	80/1124	175/7206	1.21279738379e-21
ko04725	Cholinergic synapse	75/1124	160/7206	3.65399098168e-21
ko04024	cAMP signaling pathway	103/1124	279/7206	5.83207467167e-19
ko04721	Synaptic vesicle cycle	45/1124	80/7206	4.9773541751e-17
ko04911	Insulin secretion	53/1124	117/7206	1.62720512678e-14
ko04726	Serotonergic synapse	58/1124	137/7206	3.69959831652e-14
ko04020	Calcium signaling pathway	90/1124	265/7206	4.08892608374e-14
ko04742	Taste transduction	35/1124	61/7206	6.96942416613e-14
ko04921	Oxytocin signaling pathway	75/1124	209/7206	2.41046367331e-13
ko04744	Phototransduction	25/1124	36/7206	5.58441802783e-13
ko04261	Adrenergic signaling in cardiomyocytes	73/1124	205/7206	1.13512998913e-12
ko05031	Amphetamine addiction	40/1124	91/7206	9.02539085509e-11
ko05030	Cocaine addiction	34/1124	73/7206	3.51333921181e-10
ko03040	Spliceosome	1/1124	145/7206	8.38362935935e-10
ko04720	Long-term potentiation	40/1124	99/7206	1.94189565692e-09
ko04925	Aldosterone synthesis and secretion	40/1124	105/7206	1.45164116721e-08
ko04010	MAPK signaling pathway	88/1124	321/7206	3.69593474455e-08
ko04970	Salivary secretion	36/1124	95/7206	8.97856456605e-08
ko03013	RNA transport	5/1124	166/7206	2.03044881691e-07
ko04971	Gastric acid secretion	36/1124	98/7206	2.77440824439e-07
ko04022	cGMP-PKG signaling pathway	63/1124	216/7206	2.8815026164e-07
ko04360	Axon guidance	66/1124	233/7206	4.93802442652e-07
ko04070	Phosphatidylinositol signaling system	38/1124	112/7206	1.17885771725e-06
ko04072	Phospholipase D signaling pathway	57/1124	197/7206	1.93191339791e-06
ko05322	Systemic lupus erythematosus	5/1124	151/7206	2.04152489707e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1124	74/7206	2.50571615982e-06
ko04972	Pancreatic secretion	37/1124	111/7206	3.76536957054e-06
ko05203	Viral carcinogenesis	18/1124	277/7206	4.15012648715e-06
ko04014	Ras signaling pathway	72/1124	279/7206	6.84925244325e-06
ko04610	Complement and coagulation cascades	1/1124	79/7206	3.30556442919e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1124	79/7206	3.30556442919e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1124	59/7206	3.86495670246e-05
ko04060	Cytokine-cytokine receptor interaction	11/1124	191/7206	4.24604233102e-05
ko04740	Olfactory transduction	27/1124	80/7206	6.15260017126e-05
ko04915	Estrogen signaling pathway	38/1124	131/7206	7.99033252189e-05
ko04730	Long-term depression	26/1124	78/7206	0.000100701346375
ko04540	Gap junction	37/1124	128/7206	0.000110156557277
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1124	79/7206	0.000117291847798
ko05414	Dilated cardiomyopathy	33/1124	112/7206	0.000182951461822
ko05164	Influenza A	10/1124	167/7206	0.000207609221743
ko04711	Circadian rhythm - fly	8/1124	13/7206	0.000211026542153
ko04141	Protein processing in endoplasmic reticulum	12/1124	184/7206	0.00027280510273
ko04371	Apelin signaling pathway	46/1124	177/7206	0.00031510012214
ko04514	Cell adhesion molecules (CAMs)	36/1124	130/7206	0.000349757404381
ko04640	Hematopoietic cell lineage	1/1124	64/7206	0.0003961082181
ko04110	Cell cycle	9/1124	145/7206	0.000734784293956
ko05168	Herpes simplex infection	13/1124	182/7206	0.000840272853453
ko04064	NF-kappa B signaling pathway	4/1124	96/7206	0.00091152981689
ko04930	Type II diabetes mellitus	18/1124	54/7206	0.00103282377671
ko04260	Cardiac muscle contraction	28/1124	98/7206	0.00104558025428
ko05110	Vibrio cholerae infection	20/1124	63/7206	0.00127497157052
ko04923	Regulation of lipolysis in adipocytes	23/1124	77/7206	0.00134252290618
ko04924	Renin secretion	25/1124	86/7206	0.00140976516414
ko05162	Measles	7/1124	120/7206	0.00141469247375
ko04621	NOD-like receptor signaling pathway	11/1124	157/7206	0.00169106596019
ko00240	Pyrimidine metabolism	6/1124	110/7206	0.00201838907586
ko04710	Circadian rhythm	15/1124	43/7206	0.0021150920926
ko04750	Inflammatory mediator regulation of TRP channels	32/1124	122/7206	0.00227561592558
ko04612	Antigen processing and presentation	3/1124	77/7206	0.00228800293821
ko05169	Epstein-Barr virus infection	17/1124	206/7206	0.00237228509969
ko05205	Proteoglycans in cancer	25/1124	271/7206	0.00268480226853
ko04976	Bile secretion	23/1124	80/7206	0.00273728336083
ko03018	RNA degradation	4/1124	84/7206	0.00358710377954
ko04918	Thyroid hormone synthesis	24/1124	86/7206	0.00388733519093
ko04966	Collecting duct acid secretion	10/1124	26/7206	0.00397372768566
ko00330	Arginine and proline metabolism	2/1124	61/7206	0.00403585199235
ko00260	Glycine, serine and threonine metabolism	1/1124	48/7206	0.00457971360738
ko00562	Inositol phosphate metabolism	24/1124	89/7206	0.00496595631284
ko04745	Phototransduction - fly	13/1124	38/7206	0.00516157482115
ko04015	Rap1 signaling pathway	60/1124	278/7206	0.00683881243963
ko00620	Pyruvate metabolism	1/1124	46/7206	0.00691126300362
ko03420	Nucleotide excision repair	1/1124	46/7206	0.00691126300362
ko04146	Peroxisome	5/1124	89/7206	0.00736541816278
ko04912	GnRH signaling pathway	30/1124	122/7206	0.00810316945483
ko00480	Glutathione metabolism	2/1124	55/7206	0.00858305143055
ko04964	Proximal tubule bicarbonate reclamation	10/1124	29/7206	0.00962837069154
ko05140	Leishmaniasis	4/1124	75/7206	0.00991699296928
ko03022	Basal transcription factors	1/1124	44/7206	0.0105488463491
ko04217	Necroptosis	16/1124	178/7206	0.011821555542
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1124	14/7206	0.0138339714772
ko04115	p53 signaling pathway	4/1124	74/7206	0.0143473441139
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1124	40/7206	0.0152887748573
ko04071	Sphingolipid signaling pathway	37/1124	162/7206	0.0153667880173
ko04213	Longevity regulating pathway - multiple species	22/1124	86/7206	0.0157601450027
ko00380	Tryptophan metabolism	2/1124	50/7206	0.0180496182815
ko00590	Arachidonic acid metabolism	2/1124	52/7206	0.0190273531938
ko00982	Drug metabolism - cytochrome P450	1/1124	37/7206	0.0227960991
ko03410	Base excision repair	1/1124	38/7206	0.0229269766334
ko04120	Ubiquitin mediated proteolysis	12/1124	138/7206	0.0237338051541
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1124	100/7206	0.0256724958135
ko01200	Carbon metabolism	11/1124	128/7206	0.0263955341201
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1124	182/7206	0.029686579369
ko04270	Vascular smooth muscle contraction	34/1124	154/7206	0.0321876599505
ko05161	Hepatitis B	17/1124	173/7206	0.0335871043515
ko04975	Fat digestion and absorption	1/1124	35/7206	0.0338930709148
ko04722	Neurotrophin signaling pathway	35/1124	160/7206	0.0354582593309
ko05034	Alcoholism	49/1124	238/7206	0.0363063179655
ko04210	Apoptosis	18/1124	180/7206	0.0369828396839
ko00071	Fatty acid degradation	2/1124	45/7206	0.0376208725256
ko00280	Valine, leucine and isoleucine degradation	3/1124	54/7206	0.0380440843715
ko04062	Chemokine signaling pathway	42/1124	201/7206	0.0386115953251
ko05321	Inflammatory bowel disease (IBD)	3/1124	56/7206	0.0392923760001
ko05231	Choline metabolism in cancer	30/1124	134/7206	0.0399154059891
ko04914	Progesterone-mediated oocyte maturation	24/1124	104/7206	0.0406358008245
ko04962	Vasopressin-regulated water reabsorption	15/1124	58/7206	0.0431680270056
ko05016	Huntington's disease	23/1124	215/7206	0.0448658234176
ko00515	Mannose type O-glycan biosynthesis	8/1124	25/7206	0.0455637475327
ko04916	Melanogenesis	31/1124	142/7206	0.0463378249544