ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	187/1096	423/7206	1.26571518701e-49
ko04724	Glutamatergic synapse	90/1096	152/7206	2.38514752446e-36
ko05033	Nicotine addiction	50/1096	56/7206	6.24116206352e-35
ko05032	Morphine addiction	70/1096	110/7206	2.92344387033e-31
ko04713	Circadian entrainment	78/1096	136/7206	2.91219773522e-30
ko04727	GABAergic synapse	69/1096	110/7206	2.9626603086e-30
ko04728	Dopaminergic synapse	83/1096	185/7206	1.67823142536e-22
ko04725	Cholinergic synapse	75/1096	160/7206	7.58407436618e-22
ko04723	Retrograde endocannabinoid signaling	78/1096	175/7206	5.52525949564e-21
ko04024	cAMP signaling pathway	99/1096	279/7206	1.58574404492e-17
ko04911	Insulin secretion	56/1096	117/7206	4.13555530375e-17
ko04721	Synaptic vesicle cycle	44/1096	80/7206	1.3297951114e-16
ko04020	Calcium signaling pathway	93/1096	265/7206	3.02754844453e-16
ko04726	Serotonergic synapse	58/1096	137/7206	1.17589042383e-14
ko04921	Oxytocin signaling pathway	74/1096	209/7206	2.21263003677e-13
ko04742	Taste transduction	34/1096	61/7206	2.39247678479e-13
ko04744	Phototransduction	25/1096	36/7206	3.09730983009e-13
ko04261	Adrenergic signaling in cardiomyocytes	72/1096	205/7206	7.17222588407e-13
ko05031	Amphetamine addiction	40/1096	91/7206	4.05357563791e-11
ko04720	Long-term potentiation	42/1096	99/7206	5.32118097293e-11
ko03040	Spliceosome	1/1096	145/7206	1.35679398824e-09
ko04970	Salivary secretion	38/1096	95/7206	3.3474949822e-09
ko05030	Cocaine addiction	32/1096	73/7206	4.00553284537e-09
ko05203	Viral carcinogenesis	12/1096	277/7206	6.6059949181e-09
ko04925	Aldosterone synthesis and secretion	39/1096	105/7206	2.44131871202e-08
ko04971	Gastric acid secretion	37/1096	98/7206	3.37727222812e-08
ko04010	MAPK signaling pathway	85/1096	321/7206	1.05790645601e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1096	74/7206	1.06216424522e-07
ko04060	Cytokine-cytokine receptor interaction	7/1096	191/7206	3.45694821124e-07
ko04360	Axon guidance	65/1096	233/7206	3.95278208219e-07
ko04972	Pancreatic secretion	37/1096	111/7206	1.49532712885e-06
ko04022	cGMP-PKG signaling pathway	60/1096	216/7206	1.66587414326e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	24/1096	59/7206	1.85866676684e-06
ko05322	Systemic lupus erythematosus	5/1096	151/7206	3.03855313238e-06
ko03013	RNA transport	7/1096	166/7206	8.92354560691e-06
ko04740	Olfactory transduction	28/1096	80/7206	1.0487978237e-05
ko04730	Long-term depression	27/1096	78/7206	1.83589136971e-05
ko04072	Phospholipase D signaling pathway	53/1096	197/7206	1.84496219187e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1096	79/7206	2.28282167569e-05
ko04070	Phosphatidylinositol signaling system	34/1096	112/7206	4.6257953421e-05
ko04260	Cardiac muscle contraction	30/1096	98/7206	9.50656377755e-05
ko04514	Cell adhesion molecules (CAMs)	37/1096	130/7206	0.000100624279051
ko05164	Influenza A	9/1096	167/7206	0.000111877714157
ko04110	Cell cycle	7/1096	145/7206	0.000147520266008
ko04141	Protein processing in endoplasmic reticulum	11/1096	184/7206	0.000154323754611
ko04540	Gap junction	36/1096	128/7206	0.000154367358776
ko04711	Circadian rhythm - fly	8/1096	13/7206	0.000175802408364
ko05168	Herpes simplex infection	11/1096	182/7206	0.000214671695673
ko04745	Phototransduction - fly	15/1096	38/7206	0.00023950022202
ko04976	Bile secretion	25/1096	80/7206	0.000242289961004
ko05414	Dilated cardiomyopathy	32/1096	112/7206	0.000268927478319
ko04621	NOD-like receptor signaling pathway	9/1096	157/7206	0.000292433470901
ko04610	Complement and coagulation cascades	2/1096	79/7206	0.000409294468349
ko03008	Ribosome biogenesis in eukaryotes	2/1096	79/7206	0.000409294468349
ko05205	Proteoglycans in cancer	22/1096	271/7206	0.000525348013061
ko04915	Estrogen signaling pathway	35/1096	131/7206	0.000528918282324
ko04612	Antigen processing and presentation	2/1096	77/7206	0.000614132181121
ko05162	Measles	6/1096	120/7206	0.000738194420415
ko05169	Epstein-Barr virus infection	15/1096	206/7206	0.000746718646993
ko04750	Inflammatory mediator regulation of TRP channels	33/1096	122/7206	0.000790617456039
ko04014	Ras signaling pathway	63/1096	279/7206	0.000863465617937
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1096	182/7206	0.00113474622795
ko04630	Jak-STAT signaling pathway	8/1096	132/7206	0.00199193696674
ko04120	Ubiquitin mediated proteolysis	9/1096	138/7206	0.00256698331677
ko04015	Rap1 signaling pathway	60/1096	278/7206	0.00368541254687
ko04064	NF-kappa B signaling pathway	5/1096	96/7206	0.0037997608229
ko04710	Circadian rhythm	14/1096	43/7206	0.00419028816403
ko03018	RNA degradation	4/1096	84/7206	0.005249766139
ko04350	TGF-beta signaling pathway	6/1096	103/7206	0.0052626337867
ko00240	Pyrimidine metabolism	7/1096	110/7206	0.00697101388879
ko04912	GnRH signaling pathway	30/1096	122/7206	0.006992983256
ko03420	Nucleotide excision repair	1/1096	46/7206	0.00699665598857
ko05161	Hepatitis B	14/1096	173/7206	0.00704251441952
ko04146	Peroxisome	5/1096	89/7206	0.00729534373415
ko04964	Proximal tubule bicarbonate reclamation	10/1096	29/7206	0.00805998834111
ko04973	Carbohydrate digestion and absorption	13/1096	42/7206	0.00847979211292
ko03022	Basal transcription factors	1/1096	44/7206	0.0104251386882
ko05144	Malaria	1/1096	45/7206	0.0106720036799
ko00071	Fatty acid degradation	1/1096	45/7206	0.0106720036799
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1096	14/7206	0.0122472047838
ko00480	Glutathione metabolism	2/1096	55/7206	0.0128281898372
ko05321	Inflammatory bowel disease (IBD)	2/1096	56/7206	0.0133048016248
ko04640	Hematopoietic cell lineage	3/1096	64/7206	0.0137431346908
ko04115	p53 signaling pathway	4/1096	74/7206	0.014066153373
ko05140	Leishmaniasis	4/1096	75/7206	0.01422360924
ko04371	Apelin signaling pathway	39/1096	177/7206	0.0143700994673
ko04924	Renin secretion	22/1096	86/7206	0.0144240922516
ko04918	Thyroid hormone synthesis	22/1096	86/7206	0.0144240922516
ko04140	Autophagy - animal	14/1096	164/7206	0.0150332521047
ko04210	Apoptosis	16/1096	180/7206	0.0152664128883
ko05166	HTLV-I infection	30/1096	292/7206	0.0156170290405
ko00562	Inositol phosphate metabolism	22/1096	89/7206	0.0168247338674
ko00330	Arginine and proline metabolism	3/1096	61/7206	0.0194462417393
ko04217	Necroptosis	16/1096	178/7206	0.0194861179315
ko04622	RIG-I-like receptor signaling pathway	3/1096	62/7206	0.0195925718674
ko04930	Type II diabetes mellitus	15/1096	54/7206	0.0200021709213
ko00310	Lysine degradation	4/1096	73/7206	0.0201902746992
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1096	100/7206	0.0235502281466
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1096	40/7206	0.0240479427657
ko05418	Fluid shear stress and atherosclerosis	16/1096	173/7206	0.0243844706664
ko04923	Regulation of lipolysis in adipocytes	19/1096	77/7206	0.0252738714711
ko04960	Aldosterone-regulated sodium reabsorption	12/1096	41/7206	0.0254977122887
ko05016	Huntington's disease	21/1096	215/7206	0.0260068721148
ko00260	Glycine, serine and threonine metabolism	2/1096	48/7206	0.0264087031581
ko04071	Sphingolipid signaling pathway	35/1096	162/7206	0.0265488254015
ko03320	PPAR signaling pathway	4/1096	69/7206	0.0272468035617
ko04062	Chemokine signaling pathway	42/1096	201/7206	0.0279832970472
ko05202	Transcriptional misregulation in cancer	18/1096	188/7206	0.0301274922245
ko05110	Vibrio cholerae infection	16/1096	63/7206	0.0327839541083
ko04916	Melanogenesis	31/1096	142/7206	0.0329756846497
ko04657	IL-17 signaling pathway	6/1096	87/7206	0.033799446605
ko05133	Pertussis	6/1096	87/7206	0.033799446605
ko04218	Cellular senescence	17/1096	177/7206	0.0339275218032
ko04975	Fat digestion and absorption	1/1096	35/7206	0.034328244209
ko00982	Drug metabolism - cytochrome P450	1/1096	37/7206	0.0352353211361
ko04142	Lysosome	14/1096	151/7206	0.0390517138701
ko04270	Vascular smooth muscle contraction	33/1096	154/7206	0.0401863436477
ko05131	Shigellosis	6/1096	82/7206	0.0440771365146
ko04137	Mitophagy - animal	6/1096	82/7206	0.0440771365146
ko05145	Toxoplasmosis	11/1096	126/7206	0.0442781660738
ko04214	Apoptosis - fly	5/1096	72/7206	0.047861100202