ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	207/1224	423/7206	7.68903746193e-56
ko04724	Glutamatergic synapse	93/1224	152/7206	4.07375790186e-35
ko05033	Nicotine addiction	50/1224	56/7206	1.55659259292e-32
ko04713	Circadian entrainment	81/1224	136/7206	1.65848098039e-29
ko05032	Morphine addiction	71/1224	110/7206	4.00734884636e-29
ko04727	GABAergic synapse	70/1224	110/7206	3.68078242687e-28
ko04728	Dopaminergic synapse	88/1224	185/7206	1.49281269033e-22
ko04725	Cholinergic synapse	79/1224	160/7206	1.25849578804e-21
ko04721	Synaptic vesicle cycle	51/1224	80/7206	7.25248612934e-21
ko04723	Retrograde endocannabinoid signaling	81/1224	175/7206	6.72366855709e-20
ko04024	cAMP signaling pathway	109/1224	279/7206	2.71190946106e-19
ko04911	Insulin secretion	62/1224	117/7206	3.29189048655e-19
ko04020	Calcium signaling pathway	105/1224	265/7206	5.8322893459e-19
ko04726	Serotonergic synapse	67/1224	137/7206	3.18446436959e-18
ko04742	Taste transduction	40/1224	61/7206	2.83760483818e-17
ko04744	Phototransduction	29/1224	36/7206	8.71074765965e-17
ko04740	Olfactory transduction	46/1224	80/7206	2.10958849466e-16
ko04921	Oxytocin signaling pathway	83/1224	209/7206	2.30847978921e-15
ko04970	Salivary secretion	48/1224	95/7206	4.2511392691e-14
ko04261	Adrenergic signaling in cardiomyocytes	78/1224	205/7206	2.33673773771e-13
ko04720	Long-term potentiation	48/1224	99/7206	3.16945163948e-13
ko05031	Amphetamine addiction	44/1224	91/7206	3.52343224917e-12
ko03040	Spliceosome	1/1224	145/7206	7.11706050037e-11
ko04925	Aldosterone synthesis and secretion	46/1224	105/7206	8.36580152344e-11
ko04971	Gastric acid secretion	42/1224	98/7206	1.27677862295e-09
ko04540	Gap junction	49/1224	128/7206	6.53166245556e-09
ko05203	Viral carcinogenesis	15/1224	277/7206	6.54725058109e-09
ko04022	cGMP-PKG signaling pathway	70/1224	216/7206	1.82864718188e-08
ko05168	Herpes simplex infection	7/1224	182/7206	6.13666306293e-08
ko05030	Cocaine addiction	32/1224	73/7206	6.27408156137e-08
ko05322	Systemic lupus erythematosus	5/1224	151/7206	2.4922140689e-07
ko03013	RNA transport	7/1224	166/7206	5.70654164483e-07
ko04120	Ubiquitin mediated proteolysis	5/1224	138/7206	1.68378625961e-06
ko04730	Long-term depression	31/1224	78/7206	1.8467170932e-06
ko04972	Pancreatic secretion	39/1224	111/7206	2.82377095908e-06
ko04966	Collecting duct acid secretion	15/1224	26/7206	3.10242445093e-06
ko04964	Proximal tubule bicarbonate reclamation	16/1224	29/7206	3.23102812974e-06
ko04060	Cytokine-cytokine receptor interaction	11/1224	191/7206	5.14659063544e-06
ko04750	Inflammatory mediator regulation of TRP channels	41/1224	122/7206	7.3656257574e-06
ko04621	NOD-like receptor signaling pathway	8/1224	157/7206	8.26835563749e-06
ko05164	Influenza A	9/1224	167/7206	8.94458806191e-06
ko04141	Protein processing in endoplasmic reticulum	11/1224	184/7206	9.84518157648e-06
ko04360	Axon guidance	66/1224	233/7206	1.13605309699e-05
ko04745	Phototransduction - fly	18/1224	38/7206	1.33612561687e-05
ko04976	Bile secretion	30/1224	80/7206	1.37951820279e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1224	74/7206	1.45634858015e-05
ko04110	Cell cycle	7/1224	145/7206	1.55383836834e-05
ko04514	Cell adhesion molecules (CAMs)	42/1224	130/7206	1.55728716305e-05
ko04924	Renin secretion	31/1224	86/7206	1.69338587014e-05
ko05162	Measles	5/1224	120/7206	2.35384688255e-05
ko04010	MAPK signaling pathway	84/1224	321/7206	2.5156462656e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1224	79/7206	2.54299317142e-05
ko05414	Dilated cardiomyopathy	37/1224	112/7206	3.32417474566e-05
ko05110	Vibrio cholerae infection	24/1224	63/7206	5.64406375955e-05
ko04260	Cardiac muscle contraction	33/1224	98/7206	5.71721052995e-05
ko05169	Epstein-Barr virus infection	15/1224	206/7206	6.46681180076e-05
ko04070	Phosphatidylinositol signaling system	36/1224	112/7206	6.72247643914e-05
ko04072	Phospholipase D signaling pathway	55/1224	197/7206	0.00010228629684
ko03008	Ribosome biogenesis in eukaryotes	2/1224	79/7206	0.000110965105412
ko04371	Apelin signaling pathway	50/1224	177/7206	0.000152580322952
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1224	59/7206	0.000160808806089
ko04612	Antigen processing and presentation	2/1224	77/7206	0.000169531352686
ko04915	Estrogen signaling pathway	39/1224	131/7206	0.000235231248092
ko04923	Regulation of lipolysis in adipocytes	26/1224	77/7206	0.000325378720256
ko04146	Peroxisome	4/1224	89/7206	0.000550368765835
ko04912	GnRH signaling pathway	36/1224	122/7206	0.000561028607503
ko04014	Ras signaling pathway	69/1224	279/7206	0.000808075964389
ko00520	Amino sugar and nucleotide sugar metabolism	1/1224	55/7206	0.000845735482526
ko00480	Glutathione metabolism	1/1224	55/7206	0.000845735482526
ko04064	NF-kappa B signaling pathway	5/1224	96/7206	0.000873505577357
ko05140	Leishmaniasis	3/1224	75/7206	0.000990539073966
ko05205	Proteoglycans in cancer	27/1224	271/7206	0.00123251206779
ko04626	Plant-pathogen interaction	9/1224	18/7206	0.00128191954356
ko05166	HTLV-I infection	30/1224	292/7206	0.00139034537537
ko00310	Lysine degradation	3/1224	73/7206	0.0014486665674
ko04330	Notch signaling pathway	2/1224	62/7206	0.0017788214259
ko04610	Complement and coagulation cascades	4/1224	79/7206	0.00232220199842
ko04916	Melanogenesis	38/1224	142/7206	0.00310650537239
ko04657	IL-17 signaling pathway	5/1224	87/7206	0.00356670811717
ko04658	Th1 and Th2 cell differentiation	6/1224	96/7206	0.00360194678691
ko05321	Inflammatory bowel disease (IBD)	2/1224	56/7206	0.00375606035401
ko03022	Basal transcription factors	1/1224	44/7206	0.00427403964296
ko05144	Malaria	1/1224	45/7206	0.00434146473578
ko00071	Fatty acid degradation	1/1224	45/7206	0.00434146473578
ko04270	Vascular smooth muscle contraction	40/1224	154/7206	0.00451813156567
ko00240	Pyrimidine metabolism	8/1224	110/7206	0.00452264001631
ko03420	Nucleotide excision repair	1/1224	46/7206	0.00459211317432
ko04115	p53 signaling pathway	4/1224	74/7206	0.0046919522885
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1224	182/7206	0.00484611218314
ko03018	RNA degradation	5/1224	84/7206	0.00491356807166
ko05161	Hepatitis B	16/1224	173/7206	0.00536036092883
ko04922	Glucagon signaling pathway	34/1224	128/7206	0.00593073094565
ko04622	RIG-I-like receptor signaling pathway	3/1224	62/7206	0.00627065565022
ko04214	Apoptosis - fly	4/1224	72/7206	0.00667570744566
ko00590	Arachidonic acid metabolism	2/1224	52/7206	0.0082437427506
ko00330	Arginine and proline metabolism	3/1224	61/7206	0.00913940071508
ko05418	Fluid shear stress and atherosclerosis	17/1224	173/7206	0.0100596910862
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1224	100/7206	0.0104480822601
ko04217	Necroptosis	18/1224	178/7206	0.011350537201
ko05145	Toxoplasmosis	11/1224	126/7206	0.0114416153769
ko05016	Huntington's disease	23/1224	215/7206	0.0124409155722
ko04918	Thyroid hormone synthesis	24/1224	86/7206	0.0130051213634
ko01524	Platinum drug resistance	5/1224	76/7206	0.0130834187267
ko05231	Choline metabolism in cancer	34/1224	134/7206	0.0140857402762
ko04015	Rap1 signaling pathway	63/1224	278/7206	0.0142330344224
ko00630	Glyoxylate and dicarboxylate metabolism	1/1224	38/7206	0.0149133886616
ko05131	Shigellosis	6/1224	82/7206	0.0171104122741
ko04062	Chemokine signaling pathway	47/1224	201/7206	0.0171265688358
ko04659	Th17 cell differentiation	9/1224	106/7206	0.0182207215752
ko04640	Hematopoietic cell lineage	4/1224	64/7206	0.0183989102591
ko04140	Autophagy - animal	17/1224	164/7206	0.0204563100938
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1224	14/7206	0.0207432845431
ko05133	Pertussis	7/1224	87/7206	0.0215010579366
ko05215	Prostate cancer	10/1224	111/7206	0.0215608100187
ko00860	Porphyrin and chlorophyll metabolism	1/1224	34/7206	0.0217400747757
ko05222	Small cell lung cancer	7/1224	89/7206	0.0218795853419
ko04975	Fat digestion and absorption	1/1224	35/7206	0.0218963074206
ko04973	Carbohydrate digestion and absorption	13/1224	42/7206	0.0223230539669
ko04630	Jak-STAT signaling pathway	13/1224	132/7206	0.0259150535947
ko00280	Valine, leucine and isoleucine degradation	3/1224	54/7206	0.0268108760867
ko00910	Nitrogen metabolism	7/1224	19/7206	0.0306919957211
ko04620	Toll-like receptor signaling pathway	9/1224	100/7206	0.0313333227354
ko00562	Inositol phosphate metabolism	23/1224	89/7206	0.0322484740795
ko05214	Glioma	21/1224	79/7206	0.03327586216
ko05217	Basal cell carcinoma	5/1224	68/7206	0.0337167095844
ko04210	Apoptosis	20/1224	180/7206	0.034341192393
ko04978	Mineral absorption	12/1224	40/7206	0.0348084847147
ko04668	TNF signaling pathway	12/1224	120/7206	0.0373325139765
ko04974	Protein digestion and absorption	24/1224	96/7206	0.0401371529707
ko05132	Salmonella infection	9/1224	98/7206	0.0411436841824
ko04930	Type II diabetes mellitus	15/1224	54/7206	0.0438174495953
ko04350	TGF-beta signaling pathway	10/1224	103/7206	0.0472936312126
ko05320	Autoimmune thyroid disease	1/1224	29/7206	0.0483956431555
ko05340	Primary immunodeficiency	1/1224	30/7206	0.048651011129
ko05202	Transcriptional misregulation in cancer	22/1224	188/7206	0.0492816291091