ko pathway ratio_in_study ratio_in_pop p_value ko04745 Phototransduction - fly 10/224 38/7206 1.51914222537e-07 ko04911 Insulin secretion 16/224 117/7206 5.51416166757e-07 ko04713 Circadian entrainment 16/224 136/7206 4.23500929481e-06 ko04724 Glutamatergic synapse 17/224 152/7206 4.24697799766e-06 ko04070 Phosphatidylinositol signaling system 14/224 112/7206 8.44256799297e-06 ko04720 Long-term potentiation 13/224 99/7206 1.03539751459e-05 ko04626 Plant-pathogen interaction 6/224 18/7206 1.14518811673e-05 ko04728 Dopaminergic synapse 18/224 185/7206 1.58171248081e-05 ko04261 Adrenergic signaling in cardiomyocytes 19/224 205/7206 1.83288909047e-05 ko05031 Amphetamine addiction 12/224 91/7206 2.18427375939e-05 ko04721 Synaptic vesicle cycle 11/224 80/7206 3.24616224668e-05 ko04971 Gastric acid secretion 12/224 98/7206 4.64160488951e-05 ko04925 Aldosterone synthesis and secretion 12/224 105/7206 9.20524258777e-05 ko04966 Collecting duct acid secretion 6/224 26/7206 0.000115256345887 ko04020 Calcium signaling pathway 20/224 265/7206 0.000202850813356 ko05010 Alzheimer's disease 16/224 202/7206 0.000522347362193 ko04024 cAMP signaling pathway 20/224 279/7206 0.000525252420107 ko04922 Glucagon signaling pathway 12/224 128/7206 0.000596557718023 ko04970 Salivary secretion 10/224 95/7206 0.000689277436594 ko04921 Oxytocin signaling pathway 16/224 209/7206 0.000758481449269 ko04740 Olfactory transduction 9/224 80/7206 0.000785095448843 ko04924 Renin secretion 9/224 86/7206 0.00132531860192 ko04360 Axon guidance 17/224 233/7206 0.00146157424203 ko00562 Inositol phosphate metabolism 9/224 89/7206 0.00169037523629 ko04964 Proximal tubule bicarbonate reclamation 5/224 29/7206 0.00179055037845 ko04727 GABAergic synapse 10/224 110/7206 0.00213364043199 ko05214 Glioma 8/224 79/7206 0.00300411879974 ko05110 Vibrio cholerae infection 7/224 63/7206 0.0032154769899 ko04114 Oocyte meiosis 11/224 139/7206 0.00388985208604 ko04725 Cholinergic synapse 12/224 160/7206 0.00404896200032 ko04145 Phagosome 12/224 162/7206 0.00447521605447 ko04744 Phototransduction 5/224 36/7206 0.00476523186267 ko04919 Thyroid hormone signaling pathway 11/224 143/7206 0.00482576183582 ko04514 Cell adhesion molecules (CAMs) 10/224 130/7206 0.00707939040075 ko04014 Ras signaling pathway 17/224 279/7206 0.00726507048423 ko04138 Autophagy - yeast 7/224 81/7206 0.0126438795148 ko04912 GnRH signaling pathway 9/224 122/7206 0.0134607801159 ko04750 Inflammatory mediator regulation of TRP channels 9/224 122/7206 0.0134607801159 ko05152 Tuberculosis 12/224 187/7206 0.0159885580214 ko00190 Oxidative phosphorylation 9/224 127/7206 0.0171339419338 ko04152 AMPK signaling pathway 11/224 161/7206 0.017292495169 ko04015 Rap1 signaling pathway 16/224 278/7206 0.019530435992 ko05323 Rheumatoid arthritis 7/224 89/7206 0.020369247768 ko04972 Pancreatic secretion 8/224 111/7206 0.021902246391 ko04016 MAPK signaling pathway - plant 3/224 20/7206 0.0228625434241 ko05120 Epithelial cell signaling in Helicobacter pylori infection 7/224 92/7206 0.0239693545337 ko04022 cGMP-PKG signaling pathway 13/224 216/7206 0.0248980115903 ko04218 Cellular senescence 11/224 177/7206 0.0253010998386 ko05014 Amyotrophic lateral sclerosis (ALS) 6/224 74/7206 0.0270074859797 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/224 1/7206 0.0310852067722 ko04260 Cardiac muscle contraction 7/224 98/7206 0.0324362321999 ko04722 Neurotrophin signaling pathway 10/224 160/7206 0.0331694119282 ko04961 Endocrine and other factor-regulated calcium reabsorption 5/224 59/7206 0.0357040021425 ko04960 Aldosterone-regulated sodium reabsorption 4/224 41/7206 0.0375026514898 ko04726 Serotonergic synapse 9/224 137/7206 0.0392703253583 ko00051 Fructose and mannose metabolism 4/224 42/7206 0.0404764745421 ko04973 Carbohydrate digestion and absorption 4/224 42/7206 0.0404764745421 ko04137 Mitophagy - animal 6/224 82/7206 0.0417166871504 ko05168 Herpes simplex infection 1/224 182/7206 0.0468766916595 ko04151 PI3K-Akt signaling pathway 19/224 390/7206 0.0493735376336