ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	183/964	423/7206	8.59859170808e-56
ko04724	Glutamatergic synapse	79/964	152/7206	1.23956995968e-30
ko05033	Nicotine addiction	44/964	56/7206	1.70770137499e-28
ko04713	Circadian entrainment	67/964	136/7206	2.367026976e-24
ko05032	Morphine addiction	57/964	110/7206	2.8576051256e-22
ko04728	Dopaminergic synapse	76/964	185/7206	2.45312280235e-21
ko04020	Calcium signaling pathway	93/964	265/7206	3.60823063303e-20
ko04727	GABAergic synapse	54/964	110/7206	9.69084794744e-20
ko04024	cAMP signaling pathway	94/964	279/7206	5.55296950708e-19
ko04725	Cholinergic synapse	64/964	160/7206	2.01434996034e-17
ko04921	Oxytocin signaling pathway	75/964	209/7206	4.69536210413e-17
ko04723	Retrograde endocannabinoid signaling	67/964	175/7206	5.16724726506e-17
ko04911	Insulin secretion	52/964	117/7206	1.08973127321e-16
ko04721	Synaptic vesicle cycle	41/964	80/7206	3.96983193816e-16
ko04726	Serotonergic synapse	53/964	137/7206	6.44694692724e-14
ko05031	Amphetamine addiction	39/964	91/7206	3.23653382643e-12
ko04742	Taste transduction	30/964	61/7206	1.49602902126e-11
ko04261	Adrenergic signaling in cardiomyocytes	64/964	205/7206	1.80710161365e-11
ko04720	Long-term potentiation	39/964	99/7206	7.37305080971e-11
ko04970	Salivary secretion	37/964	95/7206	3.35044938371e-10
ko04925	Aldosterone synthesis and secretion	37/964	105/7206	8.65063219296e-09
ko05203	Viral carcinogenesis	10/964	277/7206	3.96594753057e-08
ko03010	Ribosome	1/964	129/7206	2.89394342168e-07
ko03040	Spliceosome	2/964	145/7206	3.85403621357e-07
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/964	79/7206	4.91505257481e-07
ko04971	Gastric acid secretion	32/964	98/7206	6.46807303611e-07
ko05030	Cocaine addiction	26/964	73/7206	1.12784677013e-06
ko05168	Herpes simplex infection	5/964	182/7206	1.26063825737e-06
ko04010	MAPK signaling pathway	74/964	321/7206	1.33325052063e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	26/964	74/7206	1.52127664055e-06
ko04740	Olfactory transduction	27/964	80/7206	2.35544542522e-06
ko04022	cGMP-PKG signaling pathway	54/964	216/7206	3.39771737701e-06
ko04060	Cytokine-cytokine receptor interaction	7/964	191/7206	7.51721136477e-06
ko05322	Systemic lupus erythematosus	4/964	151/7206	8.95404836561e-06
ko04972	Pancreatic secretion	32/964	111/7206	1.4805472564e-05
ko04730	Long-term depression	25/964	78/7206	1.5551209085e-05
ko04260	Cardiac muscle contraction	29/964	98/7206	3.02824748008e-05
ko04514	Cell adhesion molecules (CAMs)	35/964	130/7206	3.68664925695e-05
ko04745	Phototransduction - fly	15/964	38/7206	5.40011030122e-05
ko05414	Dilated cardiomyopathy	31/964	112/7206	5.77131009711e-05
ko04070	Phosphatidylinositol signaling system	31/964	112/7206	5.77131009711e-05
ko04360	Axon guidance	53/964	233/7206	7.5861557461e-05
ko04744	Phototransduction	14/964	36/7206	0.000115869451885
ko03013	RNA transport	7/964	166/7206	0.000117483749182
ko04750	Inflammatory mediator regulation of TRP channels	32/964	122/7206	0.000127958421329
ko04540	Gap junction	33/964	128/7206	0.000182576273625
ko05169	Epstein-Barr virus infection	11/964	206/7206	0.000240213680109
ko05410	Hypertrophic cardiomyopathy (HCM)	27/964	100/7206	0.00027599022253
ko04621	NOD-like receptor signaling pathway	7/964	157/7206	0.000319980747411
ko04924	Renin secretion	24/964	86/7206	0.000321861013171
ko05164	Influenza A	8/964	167/7206	0.000328387365357
ko04120	Ubiquitin mediated proteolysis	6/964	138/7206	0.000590049387806
ko04141	Protein processing in endoplasmic reticulum	10/964	184/7206	0.000606034542529
ko04915	Estrogen signaling pathway	32/964	131/7206	0.000619705773344
ko04072	Phospholipase D signaling pathway	43/964	197/7206	0.000913263754794
ko04110	Cell cycle	7/964	145/7206	0.00118468284957
ko04626	Plant-pathogen interaction	8/964	18/7206	0.00125857182238
ko04550	Signaling pathways regulating pluripotency of stem cells	9/964	165/7206	0.00159231416488
ko05161	Hepatitis B	10/964	173/7206	0.00205337857032
ko04610	Complement and coagulation cascades	2/964	79/7206	0.00223200610956
ko03008	Ribosome biogenesis in eukaryotes	2/964	79/7206	0.00223200610956
ko04330	Notch signaling pathway	1/964	62/7206	0.00229879776501
ko04922	Glucagon signaling pathway	29/964	128/7206	0.00361088973626
ko00562	Inositol phosphate metabolism	22/964	89/7206	0.00407973437963
ko04630	Jak-STAT signaling pathway	7/964	132/7206	0.00413182088419
ko05162	Measles	6/964	120/7206	0.00416020999426
ko04214	Apoptosis - fly	2/964	72/7206	0.0045779776582
ko00310	Lysine degradation	2/964	73/7206	0.00474980737481
ko04966	Collecting duct acid secretion	9/964	26/7206	0.00490170283778
ko04064	NF-kappa B signaling pathway	4/964	96/7206	0.00581209422842
ko05202	Transcriptional misregulation in cancer	13/964	188/7206	0.00639239698978
ko05166	HTLV-I infection	24/964	292/7206	0.00642891041443
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/964	14/7206	0.00650852151724
ko04912	GnRH signaling pathway	27/964	122/7206	0.0068846606775
ko00480	Glutathione metabolism	1/964	55/7206	0.00803360366646
ko05205	Proteoglycans in cancer	22/964	271/7206	0.00812953108715
ko05110	Vibrio cholerae infection	16/964	63/7206	0.00859028784835
ko05200	Pathways in cancer	47/964	492/7206	0.00901227779006
ko01524	Platinum drug resistance	3/964	76/7206	0.0104190334936
ko04612	Antigen processing and presentation	3/964	77/7206	0.0105363526792
ko00240	Pyrimidine metabolism	6/964	110/7206	0.0105578658626
ko05215	Prostate cancer	6/964	111/7206	0.0106671665631
ko04964	Proximal tubule bicarbonate reclamation	9/964	29/7206	0.0108472675771
ko04146	Peroxisome	4/964	89/7206	0.0110895960046
ko04014	Ras signaling pathway	52/964	279/7206	0.0117169541485
ko04976	Bile secretion	19/964	80/7206	0.0118526753652
ko05140	Leishmaniasis	3/964	75/7206	0.015326303247
ko05010	Alzheimer's disease	39/964	202/7206	0.0156050036264
ko04270	Vascular smooth muscle contraction	31/964	154/7206	0.0164820512845
ko03420	Nucleotide excision repair	1/964	46/7206	0.0166217358711
ko05219	Bladder cancer	1/964	48/7206	0.0169698118724
ko04371	Apelin signaling pathway	35/964	177/7206	0.0181558006006
ko04015	Rap1 signaling pathway	51/964	278/7206	0.019025092293
ko04350	TGF-beta signaling pathway	6/964	103/7206	0.019288063162
ko04510	Focal adhesion	20/964	240/7206	0.0201177937058
ko04973	Carbohydrate digestion and absorption	11/964	42/7206	0.0216973353826
ko04114	Oocyte meiosis	28/964	139/7206	0.0230371905345
ko00071	Fatty acid degradation	1/964	45/7206	0.0251122022326
ko04930	Type II diabetes mellitus	13/964	54/7206	0.0270060378973
ko05222	Small cell lung cancer	5/964	89/7206	0.0275306696967
ko05321	Inflammatory bowel disease (IBD)	2/964	56/7206	0.0282010026606
ko04668	TNF signaling pathway	8/964	120/7206	0.0294791639191
ko04961	Endocrine and other factor-regulated calcium reabsorption	14/964	59/7206	0.0316513992656
ko05206	MicroRNAs in cancer	14/964	177/7206	0.032808044947
ko04916	Melanogenesis	28/964	142/7206	0.0332673583587
ko00980	Metabolism of xenobiotics by cytochrome P450	1/964	40/7206	0.036114831919
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/964	182/7206	0.0362917846807
ko04140	Autophagy - animal	13/964	164/7206	0.0365048943369
ko05220	Chronic myeloid leukemia	5/964	85/7206	0.0372292999507
ko04657	IL-17 signaling pathway	5/964	87/7206	0.0377073973111
ko00680	Methane metabolism	9/964	34/7206	0.0382833327607
ko04115	p53 signaling pathway	4/964	74/7206	0.0392950555007
ko04640	Hematopoietic cell lineage	3/964	64/7206	0.040709949448
ko04923	Regulation of lipolysis in adipocytes	17/964	77/7206	0.0409404890492
ko00280	Valine, leucine and isoleucine degradation	2/964	54/7206	0.0414150558818
ko04210	Apoptosis	15/964	180/7206	0.0454101076211