ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	201/1116	423/7206	1.3164472264e-58
ko04724	Glutamatergic synapse	87/1116	152/7206	5.83406797219e-33
ko05033	Nicotine addiction	47/1116	56/7206	6.74005901728e-30
ko05032	Morphine addiction	66/1116	110/7206	7.23361355077e-27
ko04713	Circadian entrainment	74/1116	136/7206	3.06203208442e-26
ko04727	GABAergic synapse	64/1116	110/7206	5.00654820424e-25
ko04728	Dopaminergic synapse	85/1116	185/7206	2.42908731617e-23
ko04721	Synaptic vesicle cycle	51/1116	80/7206	9.76376167003e-23
ko04725	Cholinergic synapse	76/1116	160/7206	4.51680137857e-22
ko04024	cAMP signaling pathway	104/1116	279/7206	8.99088082715e-20
ko04020	Calcium signaling pathway	99/1116	265/7206	6.22996577132e-19
ko04723	Retrograde endocannabinoid signaling	75/1116	175/7206	1.59810599474e-18
ko04742	Taste transduction	39/1116	61/7206	9.8381761336e-18
ko04726	Serotonergic synapse	61/1116	137/7206	3.11339302946e-16
ko04911	Insulin secretion	55/1116	117/7206	4.97056878415e-16
ko04921	Oxytocin signaling pathway	77/1116	209/7206	1.47535110054e-14
ko04720	Long-term potentiation	46/1116	99/7206	2.22126952227e-13
ko04744	Phototransduction	25/1116	36/7206	4.72676609375e-13
ko04261	Adrenergic signaling in cardiomyocytes	72/1116	205/7206	2.15376138969e-12
ko05031	Amphetamine addiction	42/1116	91/7206	3.3017296307e-12
ko04970	Salivary secretion	42/1116	95/7206	1.90409388955e-11
ko04740	Olfactory transduction	37/1116	80/7206	6.06176720486e-11
ko03040	Spliceosome	1/1116	145/7206	8.39672919055e-10
ko04925	Aldosterone synthesis and secretion	40/1116	105/7206	1.17874121844e-08
ko05030	Cocaine addiction	31/1116	73/7206	2.73320205896e-08
ko05168	Herpes simplex infection	5/1116	182/7206	3.11432239211e-08
ko04022	cGMP-PKG signaling pathway	65/1116	216/7206	4.7598040494e-08
ko04971	Gastric acid secretion	37/1116	98/7206	5.49961383082e-08
ko05203	Viral carcinogenesis	14/1116	277/7206	6.13190194411e-08
ko04060	Cytokine-cytokine receptor interaction	7/1116	191/7206	2.33519593583e-07
ko04360	Axon guidance	66/1116	233/7206	4.3621651616e-07
ko04010	MAPK signaling pathway	84/1116	321/7206	4.92851572691e-07
ko04966	Collecting duct acid secretion	15/1116	26/7206	9.22254739848e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1116	74/7206	2.16739589215e-06
ko04730	Long-term depression	29/1116	78/7206	2.17444036991e-06
ko04120	Ubiquitin mediated proteolysis	4/1116	138/7206	2.24841780713e-06
ko04924	Renin secretion	31/1116	86/7206	2.58302489079e-06
ko04540	Gap junction	41/1116	128/7206	2.76150733914e-06
ko03013	RNA transport	7/1116	166/7206	6.08831409195e-06
ko05164	Influenza A	7/1116	167/7206	6.25231566758e-06
ko04972	Pancreatic secretion	36/1116	111/7206	7.22080551916e-06
ko05322	Systemic lupus erythematosus	6/1116	151/7206	1.09177075056e-05
ko04514	Cell adhesion molecules (CAMs)	40/1116	130/7206	1.17005914545e-05
ko04745	Phototransduction - fly	17/1116	38/7206	1.692270931e-05
ko04621	NOD-like receptor signaling pathway	7/1116	157/7206	1.75515256434e-05
ko04260	Cardiac muscle contraction	32/1116	98/7206	2.71342657619e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1116	79/7206	3.05847374713e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1116	59/7206	3.45142109148e-05
ko05110	Vibrio cholerae infection	23/1116	63/7206	5.78290979517e-05
ko04014	Ras signaling pathway	68/1116	279/7206	9.07477709685e-05
ko04110	Cell cycle	7/1116	145/7206	0.000102022295157
ko04141	Protein processing in endoplasmic reticulum	11/1116	184/7206	0.00011146183743
ko04976	Bile secretion	26/1116	80/7206	0.000127512009523
ko05414	Dilated cardiomyopathy	33/1116	112/7206	0.000170603594801
ko05169	Epstein-Barr virus infection	14/1116	206/7206	0.000183711083793
ko04750	Inflammatory mediator regulation of TRP channels	35/1116	122/7206	0.00019561333162
ko04072	Phospholipase D signaling pathway	50/1116	197/7206	0.00028308861218
ko04612	Antigen processing and presentation	2/1116	77/7206	0.00040056008444
ko04610	Complement and coagulation cascades	2/1116	79/7206	0.000420792534017
ko03008	Ribosome biogenesis in eukaryotes	2/1116	79/7206	0.000420792534017
ko05162	Measles	6/1116	120/7206	0.00051365425186
ko05140	Leishmaniasis	2/1116	75/7206	0.000593316287649
ko04070	Phosphatidylinositol signaling system	31/1116	112/7206	0.000853817514111
ko04915	Estrogen signaling pathway	35/1116	131/7206	0.00086523968023
ko04064	NF-kappa B signaling pathway	4/1116	96/7206	0.000893380934442
ko04371	Apelin signaling pathway	44/1116	177/7206	0.00101522954576
ko04146	Peroxisome	4/1116	89/7206	0.00177588329358
ko00480	Glutathione metabolism	1/1116	55/7206	0.00211819576774
ko05205	Proteoglycans in cancer	25/1116	271/7206	0.00266169120349
ko04964	Proximal tubule bicarbonate reclamation	11/1116	29/7206	0.0027359114166
ko04640	Hematopoietic cell lineage	2/1116	64/7206	0.00277048514128
ko00590	Arachidonic acid metabolism	1/1116	52/7206	0.00313100901327
ko04626	Plant-pathogen interaction	8/1116	18/7206	0.0033017465426
ko05166	HTLV-I infection	28/1116	292/7206	0.00371477181007
ko00330	Arginine and proline metabolism	2/1116	61/7206	0.00405251198296
ko04330	Notch signaling pathway	2/1116	62/7206	0.00409757252035
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1116	182/7206	0.00484736320068
ko04912	GnRH signaling pathway	31/1116	122/7206	0.00501485696238
ko00240	Pyrimidine metabolism	7/1116	110/7206	0.00503566948974
ko05161	Hepatitis B	14/1116	173/7206	0.00537726817996
ko04923	Regulation of lipolysis in adipocytes	21/1116	77/7206	0.00672739330326
ko03420	Nucleotide excision repair	1/1116	46/7206	0.00690660192441
ko05321	Inflammatory bowel disease (IBD)	2/1116	56/7206	0.00862761954987
ko04015	Rap1 signaling pathway	59/1116	278/7206	0.00872128046353
ko01524	Platinum drug resistance	4/1116	76/7206	0.0100015977882
ko04630	Jak-STAT signaling pathway	10/1116	132/7206	0.0101853398067
ko04657	IL-17 signaling pathway	5/1116	87/7206	0.0102809090432
ko05418	Fluid shear stress and atherosclerosis	15/1116	173/7206	0.010374423017
ko03022	Basal transcription factors	1/1116	44/7206	0.0104745729921
ko05144	Malaria	1/1116	45/7206	0.0109834549675
ko00071	Fatty acid degradation	1/1116	45/7206	0.0109834549675
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1116	100/7206	0.0117661712899
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1116	14/7206	0.0133660441778
ko04916	Melanogenesis	33/1116	142/7206	0.0135069678344
ko05131	Shigellosis	5/1116	82/7206	0.0137378908912
ko00310	Lysine degradation	4/1116	73/7206	0.0139448164192
ko04214	Apoptosis - fly	4/1116	72/7206	0.0139484159183
ko03018	RNA degradation	5/1116	84/7206	0.01407462743
ko05145	Toxoplasmosis	10/1116	126/7206	0.0175084374855
ko00380	Tryptophan metabolism	2/1116	50/7206	0.0181261308804
ko04622	RIG-I-like receptor signaling pathway	3/1116	62/7206	0.019993650327
ko05034	Alcoholism	50/1116	238/7206	0.0222670157773
ko04658	Th1 and Th2 cell differentiation	7/1116	96/7206	0.0225852560131
ko03410	Base excision repair	1/1116	38/7206	0.0229122960675
ko05133	Pertussis	6/1116	87/7206	0.024383104445
ko00260	Glycine, serine and threonine metabolism	2/1116	48/7206	0.0262278938988
ko04217	Necroptosis	17/1116	178/7206	0.0270408995506
ko04350	TGF-beta signaling pathway	8/1116	103/7206	0.0275499371546
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1116	92/7206	0.0294785133278
ko05231	Choline metabolism in cancer	30/1116	134/7206	0.0299796163105
ko04270	Vascular smooth muscle contraction	34/1116	154/7206	0.0315110483355
ko04115	p53 signaling pathway	5/1116	74/7206	0.0351012749336
ko04620	Toll-like receptor signaling pathway	8/1116	100/7206	0.0362512239257
ko04071	Sphingolipid signaling pathway	35/1116	162/7206	0.0362603419071
ko04062	Chemokine signaling pathway	42/1116	201/7206	0.0374080323763
ko00280	Valine, leucine and isoleucine degradation	3/1116	54/7206	0.0382247136413
ko00620	Pyruvate metabolism	2/1116	46/7206	0.038243122627
ko05214	Glioma	19/1116	79/7206	0.0414260522377
ko04722	Neurotrophin signaling pathway	34/1116	160/7206	0.0465082229253
ko04922	Glucagon signaling pathway	28/1116	128/7206	0.0485482116309