ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	200/1197	423/7206	1.77676062414e-52
ko04724	Glutamatergic synapse	88/1197	152/7206	1.90837431014e-31
ko05033	Nicotine addiction	46/1197	56/7206	4.25055557774e-27
ko04713	Circadian entrainment	75/1197	136/7206	4.4399209553e-25
ko05032	Morphine addiction	66/1197	110/7206	4.72903433132e-25
ko04727	GABAergic synapse	63/1197	110/7206	1.98044009002e-22
ko04728	Dopaminergic synapse	85/1197	185/7206	3.12354148986e-21
ko04721	Synaptic vesicle cycle	50/1197	80/7206	2.30040926347e-20
ko04020	Calcium signaling pathway	105/1197	265/7206	8.9352139729e-20
ko04725	Cholinergic synapse	74/1197	160/7206	8.05981459802e-19
ko04024	cAMP signaling pathway	103/1197	279/7206	7.20687520995e-17
ko04723	Retrograde endocannabinoid signaling	75/1197	175/7206	9.72229072078e-17
ko04726	Serotonergic synapse	63/1197	137/7206	4.8489954722e-16
ko04911	Insulin secretion	56/1197	117/7206	2.40497222641e-15
ko04921	Oxytocin signaling pathway	79/1197	209/7206	8.36587109136e-14
ko05031	Amphetamine addiction	44/1197	91/7206	1.59305547863e-12
ko04744	Phototransduction	25/1197	36/7206	2.41220654733e-12
ko04742	Taste transduction	34/1197	61/7206	3.24570583425e-12
ko04970	Salivary secretion	42/1197	95/7206	1.91528075309e-10
ko04720	Long-term potentiation	43/1197	99/7206	2.33306967246e-10
ko04261	Adrenergic signaling in cardiomyocytes	69/1197	205/7206	1.44007212798e-09
ko03010	Ribosome	1/1197	129/7206	2.50509732119e-09
ko03040	Spliceosome	2/1197	145/7206	2.54148608213e-09
ko04925	Aldosterone synthesis and secretion	42/1197	105/7206	1.22571439345e-08
ko04740	Olfactory transduction	33/1197	80/7206	1.32415729518e-07
ko04022	cGMP-PKG signaling pathway	66/1197	216/7206	2.26045942625e-07
ko04971	Gastric acid secretion	37/1197	98/7206	3.65324470785e-07
ko05322	Systemic lupus erythematosus	5/1197	151/7206	3.81040921836e-07
ko05030	Cocaine addiction	30/1197	73/7206	5.41868224394e-07
ko05203	Viral carcinogenesis	19/1197	277/7206	1.42595912452e-06
ko05168	Herpes simplex infection	9/1197	182/7206	2.36978170037e-06
ko04621	NOD-like receptor signaling pathway	7/1197	157/7206	3.73473422565e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1197	74/7206	4.01997620205e-06
ko03013	RNA transport	8/1197	166/7206	4.23202631809e-06
ko04060	Cytokine-cytokine receptor interaction	11/1197	191/7206	7.31749866355e-06
ko04730	Long-term depression	29/1197	78/7206	9.76714481103e-06
ko04120	Ubiquitin mediated proteolysis	6/1197	138/7206	1.38386243727e-05
ko04966	Collecting duct acid secretion	14/1197	26/7206	1.50675943336e-05
ko04070	Phosphatidylinositol signaling system	37/1197	112/7206	1.63683439111e-05
ko05164	Influenza A	9/1197	167/7206	1.92303647188e-05
ko04110	Cell cycle	7/1197	145/7206	2.25538898722e-05
ko04972	Pancreatic secretion	36/1197	111/7206	4.6121790461e-05
ko04010	MAPK signaling pathway	81/1197	321/7206	5.92684076535e-05
ko04514	Cell adhesion molecules (CAMs)	40/1197	130/7206	6.43940758997e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1197	79/7206	0.00011109304804
ko04360	Axon guidance	61/1197	233/7206	0.000156284385222
ko04745	Phototransduction - fly	16/1197	38/7206	0.000175130065784
ko04141	Protein processing in endoplasmic reticulum	13/1197	184/7206	0.000177855672705
ko04540	Gap junction	38/1197	128/7206	0.000177927811096
ko03008	Ribosome biogenesis in eukaryotes	2/1197	79/7206	0.000178457153136
ko04750	Inflammatory mediator regulation of TRP channels	37/1197	122/7206	0.000181140501139
ko04976	Bile secretion	27/1197	80/7206	0.000195189317074
ko04072	Phospholipase D signaling pathway	53/1197	197/7206	0.000203262910643
ko04710	Circadian rhythm	17/1197	43/7206	0.000276447967552
ko05110	Vibrio cholerae infection	22/1197	63/7206	0.000448495974401
ko05169	Epstein-Barr virus infection	17/1197	206/7206	0.000581642035851
ko04924	Renin secretion	27/1197	86/7206	0.000642665632183
ko04610	Complement and coagulation cascades	3/1197	79/7206	0.000697288415069
ko05162	Measles	7/1197	120/7206	0.000710527726427
ko04014	Ras signaling pathway	68/1197	279/7206	0.000722359214291
ko05414	Dilated cardiomyopathy	33/1197	112/7206	0.000729497052706
ko04930	Type II diabetes mellitus	19/1197	54/7206	0.000756298461881
ko00520	Amino sugar and nucleotide sugar metabolism	1/1197	55/7206	0.000841470908275
ko04922	Glucagon signaling pathway	36/1197	128/7206	0.00105663839783
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1197	59/7206	0.00115711251272
ko05166	HTLV-I infection	29/1197	292/7206	0.00126116381905
ko04964	Proximal tubule bicarbonate reclamation	12/1197	29/7206	0.00135993223743
ko04371	Apelin signaling pathway	46/1197	177/7206	0.00140002402359
ko04260	Cardiac muscle contraction	29/1197	98/7206	0.00140833171261
ko04330	Notch signaling pathway	2/1197	62/7206	0.00176856082585
ko05205	Proteoglycans in cancer	27/1197	271/7206	0.00200352139078
ko04973	Carbohydrate digestion and absorption	15/1197	42/7206	0.00259213012952
ko04915	Estrogen signaling pathway	35/1197	131/7206	0.00289991037925
ko04630	Jak-STAT signaling pathway	10/1197	132/7206	0.0030385221321
ko05161	Hepatitis B	15/1197	173/7206	0.00356341593793
ko03420	Nucleotide excision repair	1/1197	46/7206	0.00442563733313
ko05140	Leishmaniasis	4/1197	75/7206	0.0047881860982
ko04612	Antigen processing and presentation	4/1197	77/7206	0.00491283270035
ko04626	Plant-pathogen interaction	8/1197	18/7206	0.00516994445578
ko04960	Aldosterone-regulated sodium reabsorption	14/1197	41/7206	0.00528832268966
ko00240	Pyrimidine metabolism	8/1197	110/7206	0.00625048008845
ko03022	Basal transcription factors	1/1197	44/7206	0.00679415595844
ko04622	RIG-I-like receptor signaling pathway	3/1197	62/7206	0.00920360338108
ko04146	Peroxisome	6/1197	89/7206	0.00930078241026
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1197	100/7206	0.00936790507784
ko04270	Vascular smooth muscle contraction	38/1197	154/7206	0.0112980755058
ko04064	NF-kappa B signaling pathway	7/1197	96/7206	0.0121633398767
ko04657	IL-17 signaling pathway	6/1197	87/7206	0.0128503900546
ko05133	Pertussis	6/1197	87/7206	0.0128503900546
ko00562	Inositol phosphate metabolism	24/1197	89/7206	0.0138254232111
ko05145	Toxoplasmosis	11/1197	126/7206	0.015169441095
ko05219	Bladder cancer	2/1197	48/7206	0.0177071448564
ko05321	Inflammatory bowel disease (IBD)	3/1197	56/7206	0.0185046370001
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1197	14/7206	0.0186754703149
ko04510	Focal adhesion	27/1197	240/7206	0.0217034600749
ko05131	Shigellosis	6/1197	82/7206	0.023856606239
ko04214	Apoptosis - fly	5/1197	72/7206	0.0249307874249
ko05144	Malaria	2/1197	45/7206	0.0253688772482
ko00071	Fatty acid degradation	2/1197	45/7206	0.0253688772482
ko00310	Lysine degradation	5/1197	73/7206	0.0253708516646
ko04210	Apoptosis	19/1197	180/7206	0.0254803474959
ko04912	GnRH signaling pathway	30/1197	122/7206	0.0262176007311
ko00010	Glycolysis / Gluconeogenesis	20/1197	74/7206	0.0262189286725
ko00280	Valine, leucine and isoleucine degradation	3/1197	54/7206	0.0263095704731
ko04658	Th1 and Th2 cell differentiation	8/1197	96/7206	0.0265963719021
ko04918	Thyroid hormone synthesis	22/1197	86/7206	0.0289274557139
ko04923	Regulation of lipolysis in adipocytes	20/1197	77/7206	0.0312674072121
ko04217	Necroptosis	19/1197	178/7206	0.0317705948803
ko05016	Huntington's disease	24/1197	215/7206	0.0318372492525
ko04350	TGF-beta signaling pathway	9/1197	103/7206	0.0318871187165
ko00860	Porphyrin and chlorophyll metabolism	1/1197	34/7206	0.0339412356679
ko05230	Central carbon metabolism in cancer	21/1197	81/7206	0.0339574584714
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1197	92/7206	0.0344234993645
ko00590	Arachidonic acid metabolism	3/1197	52/7206	0.037500973505
ko05200	Pathways in cancer	65/1197	492/7206	0.0381628381263
ko03018	RNA degradation	7/1197	84/7206	0.0387085129373
ko00230	Purine metabolism	43/1197	194/7206	0.0397994100177
ko04620	Toll-like receptor signaling pathway	9/1197	100/7206	0.0414855089526
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1197	182/7206	0.0429689412476
ko05130	Pathogenic Escherichia coli infection	6/1197	77/7206	0.0434909893717
ko05231	Choline metabolism in cancer	31/1197	134/7206	0.0461078021552
ko05214	Glioma	20/1197	79/7206	0.0467405657075
ko05217	Basal cell carcinoma	5/1197	68/7206	0.0473028947409
ko05340	Primary immunodeficiency	1/1197	30/7206	0.0488011239818
ko04114	Oocyte meiosis	32/1197	139/7206	0.0495487350773