ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 65/376 145/7206 6.50815653683e-46 ko03008 Ribosome biogenesis in eukaryotes 33/376 79/7206 2.5229443711e-22 ko03013 RNA transport 39/376 166/7206 5.01796489413e-16 ko05322 Systemic lupus erythematosus 35/376 151/7206 2.70449757309e-14 ko04110 Cell cycle 33/376 145/7206 2.68693111426e-13 ko03030 DNA replication 15/376 38/7206 2.26071516288e-10 ko05034 Alcoholism 38/376 238/7206 3.76468962683e-10 ko05203 Viral carcinogenesis 38/376 277/7206 2.9316711751e-08 ko00240 Pyrimidine metabolism 22/376 110/7206 3.64100260101e-08 ko04111 Cell cycle - yeast 19/376 90/7206 1.28496116371e-07 ko03015 mRNA surveillance pathway 19/376 93/7206 2.22541880417e-07 ko04144 Endocytosis 2/376 342/7206 2.48570363523e-06 ko03018 RNA degradation 15/376 84/7206 2.37917910997e-05 ko03020 RNA polymerase 8/376 29/7206 8.31301573366e-05 ko05010 Alzheimer's disease 1/376 202/7206 0.000335399863251 ko03022 Basal transcription factors 9/376 44/7206 0.000362431250606 ko04115 p53 signaling pathway 12/376 74/7206 0.000396811085178 ko03410 Base excision repair 8/376 38/7206 0.000626783383732 ko03430 Mismatch repair 6/376 22/7206 0.000708541418802 ko05152 Tuberculosis 1/376 187/7206 0.000722041461854 ko03440 Homologous recombination 8/376 41/7206 0.00106772980342 ko04024 cAMP signaling pathway 4/376 279/7206 0.00143074827447 ko00230 Purine metabolism 21/376 194/7206 0.0014446228314 ko04022 cGMP-PKG signaling pathway 2/376 216/7206 0.00152536953605 ko04261 Adrenergic signaling in cardiomyocytes 2/376 205/7206 0.0021195912992 ko03420 Nucleotide excision repair 8/376 46/7206 0.00232169823359 ko04113 Meiosis - yeast 10/376 70/7206 0.00318304730955 ko04145 Phagosome 1/376 162/7206 0.00342310484882 ko05168 Herpes simplex infection 19/376 182/7206 0.00348339982476 ko03460 Fanconi anemia pathway 8/376 51/7206 0.00451487134666 ko04270 Vascular smooth muscle contraction 1/376 154/7206 0.00495507326918 ko04218 Cellular senescence 18/376 177/7206 0.0056409295221 ko03060 Protein export 5/376 23/7206 0.00580854953213 ko04510 Focal adhesion 4/376 240/7206 0.00736737614855 ko04723 Retrograde endocannabinoid signaling 2/376 175/7206 0.00880454574164 ko04380 Osteoclast differentiation 1/376 134/7206 0.0101169405678 ko04360 Axon guidance 4/376 233/7206 0.0101615479971 ko04810 Regulation of actin cytoskeleton 5/376 264/7206 0.0103036653213 ko05202 Transcriptional misregulation in cancer 18/376 188/7206 0.0115613582234 ko05145 Toxoplasmosis 1/376 126/7206 0.0146576637136 ko05142 Chagas disease (American trypanosomiasis) 1/376 130/7206 0.0149405493981 ko04514 Cell adhesion molecules (CAMs) 1/376 130/7206 0.0149405493981 ko05169 Epstein-Barr virus infection 19/376 206/7206 0.0155753927482 ko04014 Ras signaling pathway 6/376 279/7206 0.0183352991571 ko04728 Dopaminergic synapse 3/376 185/7206 0.0186534168776 ko04750 Inflammatory mediator regulation of TRP channels 1/376 122/7206 0.0215309993496 ko04724 Glutamatergic synapse 2/376 152/7206 0.0248733082443 ko05222 Small cell lung cancer 10/376 89/7206 0.0252577299238 ko05012 Parkinson's disease 2/376 155/7206 0.0257046615643 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/376 182/7206 0.0262236835413 ko04070 Phosphatidylinositol signaling system 1/376 112/7206 0.0306255230877 ko04120 Ubiquitin mediated proteolysis 13/376 138/7206 0.0325771799458 ko04530 Tight junction 5/376 228/7206 0.0333073498804 ko05219 Bladder cancer 6/376 48/7206 0.0373507197935 ko04015 Rap1 signaling pathway 7/376 278/7206 0.0380769335842 ko04520 Adherens junction 1/376 103/7206 0.0440031627714 ko04925 Aldosterone synthesis and secretion 1/376 105/7206 0.0442234456507 ko04630 Jak-STAT signaling pathway 2/376 132/7206 0.048077988524 ko04072 Phospholipase D signaling pathway 4/376 197/7206 0.0484966869853 ko04713 Circadian entrainment 2/376 136/7206 0.0486961882937