ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	174/1152	423/7206	1.0528812994e-37
ko05033	Nicotine addiction	46/1152	56/7206	7.57619123454e-28
ko04724	Glutamatergic synapse	82/1152	152/7206	1.21748813601e-27
ko05032	Morphine addiction	62/1152	110/7206	1.70270794926e-22
ko04727	GABAergic synapse	60/1152	110/7206	8.05662364406e-21
ko04713	Circadian entrainment	67/1152	136/7206	6.68876274384e-20
ko04024	cAMP signaling pathway	105/1152	279/7206	3.10484698966e-19
ko04728	Dopaminergic synapse	80/1152	185/7206	4.16184555031e-19
ko04721	Synaptic vesicle cycle	47/1152	80/7206	2.40821238429e-18
ko04725	Cholinergic synapse	67/1152	160/7206	2.51971867537e-15
ko04723	Retrograde endocannabinoid signaling	70/1152	175/7206	9.87764915964e-15
ko04020	Calcium signaling pathway	91/1152	265/7206	6.99853716237e-14
ko04921	Oxytocin signaling pathway	75/1152	209/7206	9.23468394755e-13
ko05031	Amphetamine addiction	43/1152	91/7206	2.01728330149e-12
ko04911	Insulin secretion	50/1152	117/7206	3.7596888512e-12
ko04726	Serotonergic synapse	54/1152	137/7206	2.37432565132e-11
ko04261	Adrenergic signaling in cardiomyocytes	68/1152	205/7206	7.28086210449e-10
ko04742	Taste transduction	30/1152	61/7206	1.36230623093e-09
ko04720	Long-term potentiation	40/1152	99/7206	4.06320345865e-09
ko03040	Spliceosome	2/1152	145/7206	6.47148371212e-09
ko03010	Ribosome	1/1152	129/7206	6.68764142684e-09
ko04970	Salivary secretion	37/1152	95/7206	4.9564483784e-08
ko04022	cGMP-PKG signaling pathway	65/1152	216/7206	1.31646539758e-07
ko05030	Cocaine addiction	30/1152	73/7206	2.29723327109e-07
ko04925	Aldosterone synthesis and secretion	38/1152	105/7206	5.22486745643e-07
ko04966	Collecting duct acid secretion	15/1152	26/7206	1.4025417567e-06
ko05168	Herpes simplex infection	8/1152	182/7206	1.60436104198e-06
ko04744	Phototransduction	18/1152	36/7206	2.07002009902e-06
ko04070	Phosphatidylinositol signaling system	38/1152	112/7206	2.72849403364e-06
ko04971	Gastric acid secretion	34/1152	98/7206	4.59056936587e-06
ko05322	Systemic lupus erythematosus	6/1152	151/7206	4.93893560709e-06
ko03013	RNA transport	8/1152	166/7206	1.32713846428e-05
ko04072	Phospholipase D signaling pathway	55/1152	197/7206	1.75221991134e-05
ko04745	Phototransduction - fly	17/1152	38/7206	2.59809938601e-05
ko04514	Cell adhesion molecules (CAMs)	40/1152	130/7206	2.77597581048e-05
ko05203	Viral carcinogenesis	21/1152	277/7206	3.62788265111e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1152	74/7206	4.36260528156e-05
ko04710	Circadian rhythm	18/1152	43/7206	4.52059295284e-05
ko04141	Protein processing in endoplasmic reticulum	11/1152	184/7206	5.70790979335e-05
ko04730	Long-term depression	27/1152	78/7206	5.857449469e-05
ko05110	Vibrio cholerae infection	23/1152	63/7206	7.34339151347e-05
ko05164	Influenza A	10/1152	167/7206	0.000105584368728
ko04621	NOD-like receptor signaling pathway	9/1152	157/7206	0.0001485151544
ko04110	Cell cycle	8/1152	145/7206	0.000203327474312
ko04010	MAPK signaling pathway	76/1152	321/7206	0.00023678455522
ko04612	Antigen processing and presentation	2/1152	77/7206	0.000261302812349
ko03008	Ribosome biogenesis in eukaryotes	2/1152	79/7206	0.000271346156418
ko04360	Axon guidance	58/1152	233/7206	0.000360771263018
ko04120	Ubiquitin mediated proteolysis	8/1152	138/7206	0.000379308000482
ko05140	Leishmaniasis	2/1152	75/7206	0.000386160785276
ko04060	Cytokine-cytokine receptor interaction	14/1152	191/7206	0.000427875004918
ko04014	Ras signaling pathway	67/1152	279/7206	0.000429012026227
ko04922	Glucagon signaling pathway	36/1152	128/7206	0.000547130632264
ko04915	Estrogen signaling pathway	36/1152	131/7206	0.000678212478742
ko04923	Regulation of lipolysis in adipocytes	24/1152	77/7206	0.000807870242051
ko04924	Renin secretion	26/1152	86/7206	0.000899582999067
ko04964	Proximal tubule bicarbonate reclamation	12/1152	29/7206	0.000959131120814
ko05162	Measles	7/1152	120/7206	0.000998104204743
ko00520	Amino sugar and nucleotide sugar metabolism	1/1152	55/7206	0.00132693197139
ko04930	Type II diabetes mellitus	18/1152	54/7206	0.00132872683467
ko05169	Epstein-Barr virus infection	17/1152	206/7206	0.00136489661022
ko04972	Pancreatic secretion	31/1152	111/7206	0.00148531645
ko04740	Olfactory transduction	24/1152	80/7206	0.00175149266774
ko04064	NF-kappa B signaling pathway	5/1152	96/7206	0.00184478659357
ko00562	Inositol phosphate metabolism	26/1152	89/7206	0.00186921576394
ko04260	Cardiac muscle contraction	28/1152	98/7206	0.00193298183901
ko04371	Apelin signaling pathway	44/1152	177/7206	0.00240117152943
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/1152	79/7206	0.00294120520127
ko04214	Apoptosis - fly	3/1152	72/7206	0.00319401438213
ko04217	Necroptosis	15/1152	178/7206	0.00363594651193
ko04750	Inflammatory mediator regulation of TRP channels	32/1152	122/7206	0.00377810502603
ko05414	Dilated cardiomyopathy	30/1152	112/7206	0.00381415751904
ko04626	Plant-pathogen interaction	8/1152	18/7206	0.00405019079059
ko04540	Gap junction	33/1152	128/7206	0.00470228252453
ko04610	Complement and coagulation cascades	4/1152	79/7206	0.00494645827007
ko05161	Hepatitis B	15/1152	173/7206	0.0061221754825
ko03022	Basal transcription factors	1/1152	44/7206	0.00674166147929
ko03420	Nucleotide excision repair	1/1152	46/7206	0.00711233801168
ko04657	IL-17 signaling pathway	5/1152	87/7206	0.00727559014513
ko04976	Bile secretion	22/1152	80/7206	0.00832035590971
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1152	100/7206	0.00874579084306
ko05321	Inflammatory bowel disease (IBD)	2/1152	56/7206	0.00891896737933
ko05131	Shigellosis	5/1152	82/7206	0.00977166099635
ko05145	Toxoplasmosis	10/1152	126/7206	0.00984154334202
ko04960	Aldosterone-regulated sodium reabsorption	13/1152	41/7206	0.0099497204057
ko04270	Vascular smooth muscle contraction	37/1152	154/7206	0.0100510404202
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1152	59/7206	0.011509530548
ko04210	Apoptosis	17/1152	180/7206	0.0132272292022
ko04330	Notch signaling pathway	3/1152	62/7206	0.0135355821298
ko04622	RIG-I-like receptor signaling pathway	3/1152	62/7206	0.0135355821298
ko00010	Glycolysis / Gluconeogenesis	20/1152	74/7206	0.0154582335226
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1152	14/7206	0.0155666456191
ko05133	Pertussis	6/1152	87/7206	0.0177185090009
ko05166	HTLV-I infection	32/1152	292/7206	0.0177360350632
ko04015	Rap1 signaling pathway	59/1152	278/7206	0.0191389291445
ko05230	Central carbon metabolism in cancer	21/1152	81/7206	0.0209795555272
ko05205	Proteoglycans in cancer	30/1152	271/7206	0.0225050567159
ko00630	Glyoxylate and dicarboxylate metabolism	1/1152	38/7206	0.0233511763706
ko03410	Base excision repair	1/1152	38/7206	0.0233511763706
ko00240	Pyrimidine metabolism	9/1152	110/7206	0.0248722252667
ko05200	Pathways in cancer	61/1152	492/7206	0.0255187203868
ko05219	Bladder cancer	2/1152	48/7206	0.0269508834023
ko05231	Choline metabolism in cancer	31/1152	134/7206	0.0312508368041
ko00860	Porphyrin and chlorophyll metabolism	1/1152	34/7206	0.0334536243071
ko04973	Carbohydrate digestion and absorption	12/1152	42/7206	0.0336759742992
ko04658	Th1 and Th2 cell differentiation	8/1152	96/7206	0.0357718015337
ko04916	Melanogenesis	32/1152	142/7206	0.0369935744062
ko04213	Longevity regulating pathway - multiple species	21/1152	86/7206	0.0378654249581
ko04510	Focal adhesion	27/1152	240/7206	0.0395801532037
ko05222	Small cell lung cancer	7/1152	89/7206	0.0400510359134
ko05010	Alzheimer's disease	43/1152	202/7206	0.040834156556
ko04350	TGF-beta signaling pathway	9/1152	103/7206	0.0420317501812
ko04711	Circadian rhythm - fly	5/1152	13/7206	0.0435327755526
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1152	92/7206	0.0442645567542
ko04962	Vasopressin-regulated water reabsorption	15/1152	58/7206	0.0471464070825