ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	90/892	145/7206	2.29757309648e-46
ko03013	RNA transport	72/892	166/7206	5.48966383631e-24
ko04110	Cell cycle	65/892	145/7206	1.04678428056e-22
ko03008	Ribosome biogenesis in eukaryotes	46/892	79/7206	2.09672373431e-22
ko04080	Neuroactive ligand-receptor interaction	3/892	423/7206	5.60365089662e-21
ko03030	DNA replication	30/892	38/7206	7.11536040478e-21
ko04111	Cell cycle - yeast	46/892	90/7206	2.93197364177e-19
ko03410	Base excision repair	24/892	38/7206	2.193790191e-13
ko04113	Meiosis - yeast	33/892	70/7206	6.99617463938e-13
ko04020	Calcium signaling pathway	3/892	265/7206	6.34615902354e-12
ko03460	Fanconi anemia pathway	26/892	51/7206	2.10968751585e-11
ko05217	Basal cell carcinoma	30/892	68/7206	6.39371947127e-11
ko03420	Nucleotide excision repair	24/892	46/7206	6.68619124042e-11
ko03015	mRNA surveillance pathway	36/892	93/7206	7.74983089492e-11
ko03430	Mismatch repair	16/892	22/7206	9.70342361993e-11
ko04144	Endocytosis	9/892	342/7206	1.13431483312e-10
ko00240	Pyrimidine metabolism	38/892	110/7206	1.11909360836e-09
ko03440	Homologous recombination	20/892	41/7206	1.2129215962e-08
ko04932	Non-alcoholic fatty liver disease (NAFLD)	2/892	182/7206	1.70782488225e-08
ko05012	Parkinson's disease	1/892	155/7206	4.11788356586e-08
ko04921	Oxytocin signaling pathway	4/892	209/7206	4.78748214177e-08
ko04724	Glutamatergic synapse	1/892	152/7206	6.27012207976e-08
ko04022	cGMP-PKG signaling pathway	5/892	216/7206	1.47500567774e-07
ko04723	Retrograde endocannabinoid signaling	3/892	175/7206	3.22906419762e-07
ko04621	NOD-like receptor signaling pathway	2/892	157/7206	4.44950466936e-07
ko03018	RNA degradation	27/892	84/7206	1.49625383329e-06
ko04725	Cholinergic synapse	3/892	160/7206	2.29205777774e-06
ko04726	Serotonergic synapse	2/892	137/7206	4.77073938422e-06
ko04072	Phospholipase D signaling pathway	6/892	197/7206	5.00356994859e-06
ko04060	Cytokine-cytokine receptor interaction	6/892	191/7206	1.02279027962e-05
ko04915	Estrogen signaling pathway	2/892	131/7206	1.07015898258e-05
ko04550	Signaling pathways regulating pluripotency of stem cells	41/892	165/7206	1.0710146414e-05
ko04261	Adrenergic signaling in cardiomyocytes	7/892	205/7206	1.20844808943e-05
ko04727	GABAergic synapse	1/892	110/7206	1.31656135873e-05
ko03020	RNA polymerase	13/892	29/7206	1.4785191912e-05
ko04024	cAMP signaling pathway	13/892	279/7206	1.59107901254e-05
ko04062	Chemokine signaling pathway	7/892	201/7206	1.67982800138e-05
ko04330	Notch signaling pathway	20/892	62/7206	3.20857526479e-05
ko04713	Circadian entrainment	3/892	136/7206	3.26911454237e-05
ko04911	Insulin secretion	2/892	117/7206	4.97058039071e-05
ko05166	HTLV-I infection	60/892	292/7206	5.59417617015e-05
ko04650	Natural killer cell mediated cytotoxicity	1/892	97/7206	6.66863764948e-05
ko04310	Wnt signaling pathway	41/892	181/7206	8.52260045751e-05
ko04270	Vascular smooth muscle contraction	5/892	154/7206	0.00010373252452
ko05032	Morphine addiction	2/892	110/7206	0.000107127102692
ko04972	Pancreatic secretion	2/892	111/7206	0.000109581329902
ko04371	Apelin signaling pathway	7/892	177/7206	0.000178484635406
ko00230	Purine metabolism	42/892	194/7206	0.000226892910858
ko04662	B cell receptor signaling pathway	1/892	88/7206	0.000228390863365
ko04920	Adipocytokine signaling pathway	1/892	89/7206	0.000239970718691
ko04925	Aldosterone synthesis and secretion	2/892	105/7206	0.000241807754711
ko04728	Dopaminergic synapse	8/892	185/7206	0.000254521093251
ko05202	Transcriptional misregulation in cancer	41/892	188/7206	0.000273397099791
ko00564	Glycerophospholipid metabolism	2/892	99/7206	0.000338704270932
ko03010	Ribosome	4/892	129/7206	0.000369648358339
ko05224	Breast cancer	38/892	174/7206	0.000399593784276
ko05414	Dilated cardiomyopathy	3/892	112/7206	0.000440789042826
ko04340	Hedgehog signaling pathway	17/892	58/7206	0.000451336143848
ko04740	Olfactory transduction	1/892	80/7206	0.000493598070989
ko04138	Autophagy - yeast	1/892	81/7206	0.000500984000376
ko04014	Ras signaling pathway	17/892	279/7206	0.000567133976498
ko04931	Insulin resistance	5/892	137/7206	0.000585069173871
ko04071	Sphingolipid signaling pathway	7/892	162/7206	0.000650193947472
ko04923	Regulation of lipolysis in adipocytes	1/892	77/7206	0.000737123175952
ko04912	GnRH signaling pathway	4/892	122/7206	0.000745561674135
ko04610	Complement and coagulation cascades	1/892	79/7206	0.000784996831678
ko04722	Neurotrophin signaling pathway	7/892	160/7206	0.00090973673833
ko04910	Insulin signaling pathway	8/892	172/7206	0.000910854011134
ko04390	Hippo signaling pathway	39/892	188/7206	0.00101422426114
ko05030	Cocaine addiction	1/892	73/7206	0.00109665002048
ko04514	Cell adhesion molecules (CAMs)	5/892	130/7206	0.00115110459617
ko04151	PI3K-Akt signaling pathway	29/892	390/7206	0.00152486643918
ko04924	Renin secretion	2/892	86/7206	0.00153856034215
ko05133	Pertussis	2/892	87/7206	0.00154659428777
ko04540	Gap junction	5/892	128/7206	0.00161840806454
ko04950	Maturity onset diabetes of the young	10/892	29/7206	0.00175354209117
ko05410	Hypertrophic cardiomyopathy (HCM)	3/892	100/7206	0.00189349443378
ko04152	AMPK signaling pathway	8/892	161/7206	0.00227284258676
ko04974	Protein digestion and absorption	3/892	96/7206	0.00268070855489
ko04010	MAPK signaling pathway	23/892	321/7206	0.00304865823731
ko04668	TNF signaling pathway	5/892	120/7206	0.00311063611614
ko04380	Osteoclast differentiation	6/892	134/7206	0.00321382710827
ko05231	Choline metabolism in cancer	6/892	134/7206	0.00321382710827
ko04976	Bile secretion	2/892	80/7206	0.00325116306928
ko05169	Epstein-Barr virus infection	40/892	206/7206	0.00349911112006
ko00600	Sphingolipid metabolism	1/892	63/7206	0.00360048507032
ko04217	Necroptosis	10/892	178/7206	0.00372538966021
ko04139	Mitophagy - yeast	11/892	37/7206	0.00397493911114
ko05160	Hepatitis C	8/892	153/7206	0.00412138467682
ko05142	Chagas disease (American trypanosomiasis)	6/892	130/7206	0.00436808739789
ko05152	Tuberculosis	11/892	187/7206	0.00462088009214
ko04611	Platelet activation	9/892	163/7206	0.00528964761459
ko04146	Peroxisome	3/892	89/7206	0.00541464697131
ko05031	Amphetamine addiction	3/892	91/7206	0.00561881666105
ko04922	Glucagon signaling pathway	6/892	128/7206	0.00613257504069
ko04015	Rap1 signaling pathway	20/892	278/7206	0.00678629696875
ko05140	Leishmaniasis	2/892	75/7206	0.00704292592877
ko04810	Regulation of actin cytoskeleton	19/892	264/7206	0.00747732865147
ko00670	One carbon pool by folate	7/892	20/7206	0.00784415540553
ko04962	Vasopressin-regulated water reabsorption	1/892	58/7206	0.0079770741542
ko05146	Amoebiasis	4/892	99/7206	0.00819330254374
ko04961	Endocrine and other factor-regulated calcium reabsorption	1/892	59/7206	0.00822981669113
ko04660	T cell receptor signaling pathway	6/892	124/7206	0.00824446296255
ko04620	Toll-like receptor signaling pathway	4/892	100/7206	0.00837997589555
ko04070	Phosphatidylinositol signaling system	5/892	112/7206	0.00841542472269
ko03022	Basal transcription factors	12/892	44/7206	0.00873506448658
ko04530	Tight junction	16/892	228/7206	0.0103798621312
ko04659	Th17 cell differentiation	5/892	106/7206	0.0112345408135
ko00280	Valine, leucine and isoleucine degradation	1/892	54/7206	0.0116598904761
ko04670	Leukocyte transendothelial migration	9/892	151/7206	0.0122002835391
ko01200	Carbon metabolism	7/892	128/7206	0.0140932261918
ko05222	Small cell lung cancer	19/892	89/7206	0.0144730938054
ko05120	Epithelial cell signaling in Helicobacter pylori infection	4/892	92/7206	0.0157256037016
ko04510	Focal adhesion	18/892	240/7206	0.0166739909364
ko04211	Longevity regulating pathway	7/892	123/7206	0.0187113921215
ko04066	HIF-1 signaling pathway	7/892	123/7206	0.0187113921215
ko00970	Aminoacyl-tRNA biosynthesis	11/892	44/7206	0.018830855807
ko05145	Toxoplasmosis	7/892	126/7206	0.0192034469409
ko05110	Vibrio cholerae infection	2/892	63/7206	0.0201585449819
ko04640	Hematopoietic cell lineage	2/892	64/7206	0.020385463392
ko04720	Long-term potentiation	5/892	99/7206	0.0208960154636
ko04630	Jak-STAT signaling pathway	8/892	132/7206	0.0229323512601
ko04215	Apoptosis - multiple species	1/892	47/7206	0.0252619334606
ko04012	ErbB signaling pathway	6/892	109/7206	0.0268551807923
ko05132	Salmonella infection	5/892	98/7206	0.0289394541638
ko04145	Phagosome	11/892	162/7206	0.0290560213696
ko04622	RIG-I-like receptor signaling pathway	2/892	62/7206	0.0301699094435
ko04213	Longevity regulating pathway - multiple species	4/892	86/7206	0.03026645351
ko04918	Thyroid hormone synthesis	4/892	86/7206	0.03026645351
ko04142	Lysosome	10/892	151/7206	0.0326190614436
ko04350	TGF-beta signaling pathway	20/892	103/7206	0.0346127869915
ko04216	Ferroptosis	1/892	44/7206	0.0371643553716
ko04710	Circadian rhythm	1/892	43/7206	0.0371856713724
ko05144	Malaria	1/892	45/7206	0.0377480457737
ko00620	Pyruvate metabolism	1/892	46/7206	0.0389351376405
ko05168	Herpes simplex infection	32/892	182/7206	0.039269574078
ko04137	Mitophagy - animal	4/892	82/7206	0.0409555715177
ko04712	Circadian rhythm - plant	3/892	7/7206	0.0450675123794
ko04933	AGE-RAGE signaling pathway in diabetic complications	9/892	135/7206	0.0465094992689
ko04120	Ubiquitin mediated proteolysis	25/892	138/7206	0.0489983589548
ko04914	Progesterone-mediated oocyte maturation	20/892	104/7206	0.0491024795612